| SESSION 1. (Sunday Evening)
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Formation of the Mammalian Skeleton |
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Discussion Leader: David Kingsley, Ph.D. |
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David Kingsley, Ph.D.
Stanford University |
"Genetic Control of Skeletal Development" |
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Marjolein van der Meulen, Ph.D.
Cornell University |
"Mechanical Influences During Growth & Development" |
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Robert Hensinger, M.D.
University of Michigan |
"Anomalies of Human Skeletal Morphogenesis and Growth" |
| SESSION 2. (Monday Morning)
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Growth of the Skeleton |
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Discussion Leader: A. Robin Poole, Ph.D. |
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David Ornitz, M.D.
Washington University School of Medicine |
"Regulation of Endochondral Bone Growth by Fibroblast Growth Factor Receptor 3" |
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Randy Rosier, Ph.D., M.D.
University of Rochester |
"Molecular Mechanisms of Hypertrophy" |
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Tracy Ballock, M.D.
University Hospitals of Cleveland |
"Control of Cell Proliferation in the Growth Plate" |
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Jill Helms, D.D.S.
University of California |
"Hedgehog Proteins in Skeletogenesis and Repair" |
| SESSION 3. (Monday Evening)
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The Skeleton and Cancer |
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Discussion Leader: Randy Rosier, Ph.D., M.D. |
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Theresa Guise, M.D.
University of Texas Health Science Center |
"Breast Cancer Metastases to Bone: Role of Parathyroid Hormone-Related Protein (PTHrP) and Transforming Growth Factor Beta (TGF-beta) |
|
Jacqueline Hecht, M.D.
University of Texas Medical School |
"Mutational analysis of EXT genes in Hereditary Multiple Exostoses and chondrosarcomas." |
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Anja Bosserhoff, Ph.D.
University of Regensberg |
"MIA/CD-RAP: A New Marker for Melanoma, Chondrosarcoma, and Breast Cancer" |
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Brian Snyder, Ph.D.
Harvard University |
"Mechanical Effects of Osseous Lesions" |
| SESSION 4. (Tuesday Morning)
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Repairing Bones |
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Discussion Leader: Steven Goldstein, Ph.D. |
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Arthur Veis, Ph.D.
Northwestern University |
"A New Mineralized Tissue Factor for Mesenchymal Stem Cell-Mediated Bone Repair" |
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Scott Boden, M.D.
Emory Spine Center |
"Stimulation of Bone Repair with Growth Factors: A Clinical Perspective and the Reality of Implementation" |
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Ranieri Cancedda, M.D.
National Institute for Cancer Research, Genoa, Italy |
"Cartilage Repair in vitro and in vivo in Sheep" |
| SESSION 5. (Tuesday Evening)
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A Vision of the Future From New Investigators |
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Discussion Leader: Vincent Hascall, Ph.D. |
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Kathy Derwin, Ph.D.
University of Michigan |
"A Quantitative Investigation of Structure-Function Relationships in a Tendon Fascicle Model" |
|
Davis Adkisson, Ph.D.
Washington University School of Medicine |
"In vitro Production of
Neocartilage Allografts for Articular Repair" |
|
Suneel Apte, Ph.D.
Cleveland Clinic Foundation |
"Matrix proteolysis: A Degrading Task and Necessary Evil" |
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Lisa Fortier, D.V.M.
Cornell University |
"The Equine Model of Cartilage Repair" |
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Claudia Kappen, Ph.D.
Mayo Clinic |
"The Role of Homeobox Genes in Patterning and Growth of the Skeleton" |
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Thomas Aigner, M.D.
University of Erlangen-Nürnberg |
"Altered Gene Expression Pattern in Osteoarthritic Cartilage -- Future Tools for Diagnosis, Prognosis and Therapy?" |
| SESSION 6. (Wednesday Morning)
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Soft Tissues: Muscle, Tendon and Ligament |
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Discussion Leader: Kathryn Vogel, Ph.D. |
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Richard Lieber, Ph.D.
University of California, San Diego |
"Muscle: There's More Here Than Actin and Myosin" |
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Frank Frassica, Ph.D.
Johns Hopkins University |
"Soft Tissue Attachment to a Metal Prosthesis: Is it Feasible?" |
|
Monica Driscoll, Ph.D.
Rutgers University |
"Molecular Modeling of Mechanotransduction Complexes in C. elegans: Genetic Insights into Stretch-Gated Channels" |
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James Ralphs, Ph.D.
University of Wales
Michael Benjamin
University of Wales |
"A Structural and Cell Biological View of Tendons and Ligaments in vivo" |
| SESSION 7. (Wednesday Evening)
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Cartilage Degeneration and Repair |
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Discussion Leader: Richard D. Coutts, M.D. |
| BUSINESS MEETING |
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Robert Sah, Ph.D.
University of California at San Diego |
"Biomechanics of Cartilage Repair" |
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Dick Heinegard, M.D.
University of Lund
|
"Molecular Events in Cartilage Matrix in Joint Repair" |
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Lisa Freed, M.D., Ph.D.
Massachusetts Institute of Technology |
"Tissue Engineering of Cartilage in Bioreactors" |
| SESSION 8. (Thursday Morning)
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Total Joint Replacement and Implants |
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Discussion Leader: Thomas A. Einhorn, M.D. |
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Joshua Jacobs, M.D.
Rush-Presbyterian Hospital |
"Current Science of Metal on Metal Articulating Implants" |
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Steven Teitelbaum, M.D.
Washington University School of Medicine |
"The Pathogenesis of Experimental Implant Osteolysis" |
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Harry McKellop, M.D.
Research Center Orthopaedic Hospital |
"Factors Affecting the Wear Resistance of Polyethylene in Joint Replacement" |
|
Rocky S. Tuan, Ph.D.
Thomas Jefferson University |
"Cell and Molecular Biology of Osteoblast-Biomaterial Interaction" |
| SESSION 9. (Thursday Evening)
|
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Richard Satava, M.D
Professor of Surgery, Yale University School of Medicine |
"Virtual Reality, Robotics and Telepresence Surgery: Medicine at the
Millennium" |