Conference Program
 
Antimicrobial Peptides

April 25-30, 1999
Il Ciocco Hotel and Resort
Lucca (Barga), Italy

Chair:
Jules A.. Hoffmann

Vice Chairs:
Charles Bevins & Robert E.W. Hancock

We are indebted to the following companies for supporting this conference:

  • CYSTIC FIBROSIS FOUNDATION, Bethesda, USA
  • RHÛNE-POULENC S.A., Courbevoie, France
  • ENTOMED S.A., Strasbourg, France
  • MICROLOGIX BIOTECH Inc., Vancouver, Canada
  • INTRABIOTICS PHARMACEUTICALS Inc., Mountain View, USA
  • XOMA Ltd., Berkeley, USA
  • MAGAININ PHARMACEUTICALS Inc., Plymouth Meeting, USA
  • ZENECA MOGEN Ltd., Leiden, The Netherlands

Sunday evening, April 25th, 1999
18h00 - 19h30 Dinner
19h30 J. A. Hoffmann, Chairman, Strasbourg:
Welcome address
19h45 Keynote lecture: T. Ganz, Los Angeles:
The antimicrobial peptides - an overview
Monday, April 26th
7h30 Breakfast
9h - 12h30 Novel structural aspects, novel methodologies
Chairs: R.I. Lehrer, Los Angeles & M. Zanetti, Trieste
  • P. Bulet, Strasbourg:
    Use of MALDI-TOF mass spectrometry to reveal novel immune-induced peptides in Drosophila (30 min)
  • H. Steiner, Stockholm:
    Application of differential display PCR techniques to unravel immunity genes (30min)
10h Coffee break & Photo session
  • S. Natori, Tokyo:
    Glutathion-linked antimicrobial peptides from flies (30 min)
  • I.F. Nes, Akerhus, Norway:
    Ribosomally synthesised antimicrobial peptides in bacteria : A defense system used by bacteria to survive in a competitive environment? (30 min)
  • D. Romeo, Trieste:
    Comparative studies on cathelicidins and other antimicrobial peptides for the design of efficient antibiotics (30 min)
12h30 Lunch
15h30 - 17h30 Poster session
Chairs: C. Bevins, Cleveland; W. Broekaert, Leuven; R. Hancock, Vancouver

Self-service coffee during the session

17h30 - 19h30 Antimicrobial peptides in innate immunity (A)
Chair: P. Elsbach, New York
  • R.I. Lehrer, Los Angeles:
    Antimicrobial peptides in human body fluids (50 min)
  • C. Bevins, Cleveland:
    Regulation of antimicrobial peptide synthesis in mammals in response to bacterial stimuli (50 min)
20h Dinner
Tuesday, April 27th
7h30 Breakfast
9h - 12h30 Antimicrobial peptides in innate immunity (B)
Chairs: D. Marchini, Siena & R. Gennaro, Trieste
  • J.A. Hoffmann, Strasbourg:
    Antimicrobial peptides in insect immunity (50 min)
10h Coffee break
  • F.C. Kafatos, Heidelberg:
    Innate immunity and transmission of parasites by vector insects (50 min)
  • A.J. Ouellette, Irvine:
    Role of antimicrobial peptides in intestinal defense (50 min)
12h30 Lunch
15h30 - 17h30 Poster session
Chairs: C. Bevins, Cleveland; W. Broekaert, Leuven; R. Hancock, Vancouver

Self-service coffee during the session

17h30 - 19h30 Antimicrobial peptides in innate immunity (C)
Chair: M. Simmaco, Chieti
  • D.F. Klessig, Piscataway:
    Signaling in the plant defense response (50 min)
  • W. Broekaert, Leuven:
    Antimicrobial peptides in plant immunity (50 min)
20h Dinner
Wednesday, April 28th
7h30 Breakfast

8h30 - 11h00
The Toll signaling pathway in innate immunity
Chair: J.A. Hoffmann, Strasbourg
  • F. Bazan, Palo Alto:
    A family of human receptors structurally related to Drosophila Toll (50 min)
  • B. Beutler, Dallas:
    Positional cloning of LPS, the principal susceptibility locus for Gram negative sepsis (50 min)
  • S. Akira, Hygo:
    MyD88 and TLR-4 KO mice are LPS-hyporesponsive
11h Coffee break
11h - 13h00 Resistance strategies of microorganisms
Chairs: C. Bevins, Cleveland & L. Rivas, Madrid
  • E.A. Groisman, St Louis:
    Bacterial resistance to antimicrobial peptides (50 min)
  • P. Rodriguez-Palenzuela, Madrid:
    Bacterial resistance to plant antimicrobial peptides (30 min)
  • S.I. Miller, Seattle:
    Lipid A modifications and bacterial inducible resistance to antimicrobial peptides (30 min)
12h30 Lunch
Excursion or Free
18h - 20h Mode of action (A)
Chair: C. Hetru, Strasbourg
  • R.E.W. Hancock, Vancouver:
    Design of improved antimicrobial peptides from natural templates 50min
  • D. Aunis, Strasbourg:
    New antibacterial peptides involved in neuroimmunity in mammals 50min
20h Dinner
Thursday, April 29th
7h30 Breakfast

9h - 12h30
Mode of action (B)
Chair: M. Zasloff, Philadelphia
  • Y. Shai, Rehovot:
    Molecular basis for cell selectivity by antimicrobial peptides (50 min)
  • H.G. Sahl, Bonn:
    The mode of action of lantibiotics. (50 min)
10h Coffee break
  • W.M. Shafer, Atlanta:
    A proton motive force-driven efflux pump that recognizes antibacterial peptides (30 min)
  • P.H. Axelsen, Philadelphia:
    Membrane recognition by antimicrobial peptides (50 min)
12h30 Lunch
15h -19h30 Medical and agricultural applications
Chair: S. Natori, Tokyo
  • M.A. Zasloff, Philadelphia:
    State of the art in commercial peptide applications (30 min)
  • J. Fiddes, Sunnyvale:
    Medical uses of protegrin-like peptides (30 min)
16h Coffee break
  • P.R. Abraham, Amsterdam:
    Therapeutic potential of designer antimicrobial peptides in pre-clinical models of infection (30 min)
  • B. Simons, Leiden:
    Antifungal proteins in fungal resistance strategies for plants (30 min)
  • J.M. Jaynes, Demeter:
    In vivo activity of designed antimicrobial peptides (30 min)
  • Round table discussion and business meeting
    Chair: J.A. Hoffmann, Strasbourg
20h Banquet and attribution of the Lifetime Achievement Award for Antimicrobial Peptides to Hans G. Boman
Friday, April 30th
7h30 Breakfast
Departure

Last Updated: May 8, 2006