Session 1
Sunday pm, February 7 | CHEMISTRY AND BIOLOGY OF NO: OVERVIEWS |
| Chair & Discussion Leader: Owen W Griffith (Milwaukee, WI) |
| 7:30-7:40 | Welcome and Introduction |
| 7:40-8:15 | Joe Beckman (Birmingham, AL) - Chemistry of NO and its Products |
| 8:25-9:00 | Jack Lancaster (New Orleans, LA) - Mammalian NO Biology |
| 9:10-9:50 | General Discussion |
Session 2
Monday am, February 8 | BIOLOGICAL CHEMISTRY OF NO |
| Chair & Discussion Leader: Joe Beckman (Birmingham, AL) |
| 9:00-9:35 | James Liao (Los Angeles, CA) - Simulation of NO Diffusion |
| 9:45-10:20 | Jim Hurst (Pullman, WA) - CO2 Reaction with Peroxynitrite |
| 10:30-11:00 | GROUP PHOTOGRAPH & COFFEE BREAK |
| 11:00-11:35 | George B. Richter-Addo (Norman, OK) - Binding and Activation of Nitroso Compounds by
Metalloporphyrins |
| 11:45-12:25 | General Discussion |
Session 3
Monday pm, February 8 | STRUCTURE OF NOS |
| Chair & Discussion Leader: Bettie Sue Masters (San Antonio, TX) |
| 7:30-8:05 | John Tainer (La Jolla, CA) - Structural Biochemistry of NO Synthase with Bound
Ligands, Pterin Analogues, and Inhibitors. |
| 8:15-8:40 | Bettie Sue Masters (San Antonio, TX) - Structures of Endothelial and Neuronal NO Synthases Reveal a Novel Metal Center and Present Insights Into Pterin Function |
| 8:45-9:25 | Dennis Stuehr (Cleveland, OH) - Identifying Cofactor and Domain Interaction Sites
Through Site-Directed Mutagenesis |
| 9:35-10:15 | General Discussion |
Session 4
Tuesday am, February 9 | ENZYMOLOGY OF NOS |
| Chair & Discussion Leader: Owen W. Griffith (Milwaukee, WI) |
| 9:00-9:35 | Bernd Mayer (Graz, Austria) - Role of Tetrahydrobiopterin in NOS Catalysis |
| 9:45-10:20 | Husam M. Abu-Soud (Cleveland, OH) - Kinetic Differences Among NOS Isoforms |
| 10:30-11:00 | COFFEE BREAK |
| 11:00-11:35 | Naoyuki Taniguchi (Osaka, Japan) - A Novel iNOS Inhibitor, ONO-1714: A Potent Inhibitory Activity In Vitro and In Vivo |
| 11:45-12:35 | General Discussion |
Session 5
Tuesday pm, February 9 | BIOLOGICAL TARGETS OF NO |
| Chair & Discussion Leader: Jack Lancaster (New Orleans, LA) |
| 7:30-8:05 | Claire Kennedy (Milwaukee, WI) - (NO)x and Iron Sulfur Proteins: Aconitase |
| 8:15-8:40 | Jacquin Niles (Cambridge, MA) - Nitric Oxide-Mediated Mutagenesis |
| 8:45-9:25 | Lou Ignarro (Los Angeles, CA) - cGMP-Independent Cytostasis by S-Nitrosation
of Ornithine Decarboxylase |
| 9:45-10:15 | General Discussion |
Session 6
Wednesday am, February 10 | NO TOXICITY AND DEFENSES |
| Chair & Discussion Leader: Jonathan Stamler (Durham, NC) |
| 9:00-9:35 | Lee Ann MacMillian-Crow - Nitration and Inactivation of MnSOD |
| 9:45-10:20 | Jay Groves (Princeton, NJ) - Peroxynitrite Scavengers |
| 10:30-11:00 | COFFEE BREAK |
| 11:00-11:35 | Helmut Sies (Dusseldorf, Germany) - Anti-NO Mechanisms |
| 11:45-12:35 | General Discussion |
Session 7
Wednesday pm, February 10 | KEY-NOTE LECTURE |
| 7:30-8:10 | BUSINESS MEETING |
| 8:10-9:10 | Key-note Lecture: Jonathan Stamler (Durham, NC) - Nitrosylated Hemoglobin: Endogenous Formation and Effects on Vascular Tone |
| 9:10-9:40 | General Discussion |
Session 8
Thursday am, February 11 | MICROBIAL/VIRAL RESPONSE TO NO |
| Chair & Discussion Leader: Dennis Stuehr (Cleveland, OH) |
| 9:00-9:25 | Ferric Fang (Denver, CO) - Microbial Defenses against NO-related Cytotoxicity |
| 9:45-10:20 | Carl Nathan (New York, NY) - NO Resistance Mechanisms |
| 10:30-11:00 | COFFEE BREAK |
| 11:00-11:35 | Charles Lowenstein (Baltimore, MD) - Anti-Viral Effect of NO |
| 11:45-12:25 | General Discussion |
Session 9
Thursday pm, February 11 | UNUSUAL SOURCES OF NO |
| Chair & Discussion Leader: Lou Ignarro (Los Angeles, CA) |
| 7:30-8:05 | Gillian McKnight (London, England) - Nitrate-Dependent Synthesis of NO in the Gut |
| 8:15-8:40 | Shirley Luckhart (Blacksburg, VA) - Inducible Invertebrate NO: Mosquitos and Humans Share a Defense Against Malaria Parasites |
| 8:45-9:25 | Chris Lamb (Scotland, United Kingdom) - NO in Plant Disease Resistance |
| 9:35-10:15 | General Discussion |