| Sunday, August 5th |
| 2:00pm-11:00pm | Arrival and registration |
| 6:00pm | Dinner |
| 7:30-9:30pm | Barrier assembly and degradation |
| Session Chair: Thea Mauro, University of California, San Francisco |
| Gloria Sando, University of Iowa
"Caveolins: Lipid Transport and Organizing Proteins with Diverse Functions - Do
They Play a Role in the Epidermal Barrier?" |
| Joachim Fluhr, University of California, San Francisco
"Generation of Free Fatty Acids from Phospholipids Regulates Stratum Corneum Acidification and Integrity in Adults and Neonates" |
| Allan Watkinson, Unilever Research UK
"SCCE in the Stratum Corneum: A Unique Environment for a Proteolytic Enzyme" |
| 9:30pm-10:30pm | Welcome reception |
| Monday, August 6th |
| 7:30am-8:30am | Breakfast |
| 8:30am | Conference photograph |
| 9:00am -12:30pm | Transdermal drug delivery |
| Session Chair - Martha Tate, Kimberly-Clark |
| Samir Mitragotri , University of California, Santa Barbara
"Mechanisms of Low-Frequency Sonophoresis" |
| Loan Honeywell-Nguyen, Leiden-Amsterdam Ctr for Drug Rsch
"Elastic Vesicles: Drug Transport and Mechanisms of Action" |
| Apostolos Doukas, Wellman Laboratories of Photomedicine, Boston
"Permeabilization of the Stratum Corneum with Pressure Waves: Implications for Transdermal Drug Delivery" |
| Jurgen Lademann, Humboldt University Berlin
"Open vs. Closed Follicles"
|
| 12:30pm | Lunch |
| 4:00-5:00pm | Session I posters mounted
|
| 5:00-6:00pm | First opportunity to view Session I posters |
| 6:00pm | Dinner |
| 7:30-9:30pm | Exobiotics/Immunization |
| Session Chair - Chris Cullander, University of California, San Francisco |
| Gregory Glenn, Walter Reed Army Institute of Research
"Transcutaneous Immunization: Using Adjuvants on the Skin to Induce Systemic Immune Responses" |
| William Costerton, Montana State University
"The Microbial Ecology of the Intact and Disturbed Human Skin" |
| John A. Mikszta, BD Technologies, Research Triangle Park
"Microfabricated Arrays Effectively Disrupt Skin Barrier Function and Facilitate Topical Gene Transfer and Genetic Immunization." |
| 9:30-10:30pm | Session I poster presenters stand by their posters |
| Tuesday, August 7th |
| 7:30am-8:30am | Breakfast |
| 9:00am-12:30pm | Cell and molecular biology of barrier function |
| Session Chair - Isabelle Castiel, L'Oreal |
| Carolyn Byrne, University of Manchester, UK
"Formation of the Fetal Barrier" |
| Arto Maatta, University of Durham, UK
"Role of Plakin Family of Cytoskeletal Linker Proteins in Cornified Envelope Assembly" |
| Marty Visscher, Skin Science Institute, Cincinnati
"Vernix Biology and Barrier Development" |
| Julia Segre, National Human Genome Research Institute/NIH
"A Genomics Approach to KLF4's Role in Transcriptional Control of Epidermal Barrier Establishment" |
| 12:30pm | Lunch |
| 5:00-6:00pm | Second opportunity to view posters in Session I |
| 6:00pm | Dinner |
| 7:30-9:30pm | Physical properties of skin |
| Session Chair - Joke Bouwstra, Leiden-Amsterdam Ctr for Drug Rsch |
| Peter Caspers, Erasmus University, Rotterdam
"In Vivo Depth Profiling of Water and Other Skin Constituents by Raman Microspectroscopy" |
| David Moore, Unilever US
"Lipids: Headgroup Hydrogen Bonding and Chain Behavior in Phytosphingosine and Sphingosine Ceramides" |
| Alexandre Samouilov, Johns Hopkins University School of Medicine
"Application of Electron Paramagnetic Resonance Imaging Technique for Measurement of Skin Permeability and Redox state" |
| 9:30-10:30pm | Session I poster presenters stand by posters |
| 10:30pm | Session I posters come down |
| Wednesday, August 8th |
| 7:30am-8:30am | Breakfast |
| 9:00am-12:30pm | Skin modeling |
| Session Chair - William Van Osdol, ALZA Corporation |
| Jerry Kasting, University of Cincinnati
"Evaluation of Stratum Corneum Heterogeneity by a Combination of Membrane Transport and Uptake/Desorption Techniques" |
| Lars Norlén, GAP Biomédical, Geneva
"Is the Skin Barrier a Single and Coherent Gel Phase Formed Through Unfolding of a Three-Dimensional Continuous Cubic-Like Membrane Structure with Symmetry?" |
| Annette Bunge, Colorado School of Mines
"Does Surface Distribution of Solid Chemical Affect Dermal Absorption?" |
| James Weaver, MIT
"Avoiding Math While Solving Increasingly Realistic Models for Molecular Transport Through the Stratum Corneum" |
| 12:30pm | Lunch |
| 4:00-5:00pm | Session II posters mounted
|
| 5:00-6:00pm | First opportunity to view Session II posters |
| 6:00pm | Dinner |
| 7:30-9:30pm | Debate and Business Meeting |
| Debate topic: "Skin Reservoir Function is an Artifact" |
| Moderator: Ken Walters, An-eX, Cardiff |
| Pro: Jerry Kasting, University of Cincinnati |
| Con: Mike Roberts, University of Queensland |
| 9:30-10:30pm | Session II poster presenters stand by posters
|
| Thursday, August 9th |
| 7:30am-8:30am | Breakfast |
| 9:00am-12:30pm | Skin imaging |
| Session Chair - Gopi Menon, Avon Products, Inc. |
| Roger Wepf, Beiersdorf AG
"Re-viewing the Structure of the Stratum Corneum: the Corneocytes Embrace Each Other" |
| Nik Kollias, Johnson & Johnson Consumer Products
"Macro-and-Micro Imaging of-and-through Stratum Corneum" |
| Milind Rajadhyaksha, Massachusetts General Hospital
"Confocal Imaging of Human Stratum Corneum In Vivo: Optimum Methods and Applications" |
| Martin Behne, Veterans Administration Medical Center, San Francisco
"The Stratum Corneum pH Gradient: A New Look at the "Acid Mantle"" |
| 12:30pm | Lunch |
| 5:00-6:00pm | Second opportunity to view posters in Session II |
| 6:00pm | Dinner |
| 7:30-9:30pm | Hot Topics |
| Session Chair - Maria Ponec, Leiden University Medical Center |
| Gabriele Vielhaber, Haarmann & Reimer GmbH, Holzminden
"Immunocytochemical Localization of (Glucosyl)ceramides in Human Epidermis - A Role for Epidermal Ceramides Beyond Providing the Barriers Mortar?" |
| Olga Lopez Serrano, Consejo Superior de Investigaciones Cientificas, Barcelona
"Cornified envelope: Could Fatty Acids be Covalently Linked to Serine Residues?" |
| Melanie Chopart, L'Oreal, Paris
"Free and Bound Human Ceramides. Normal and Dry skin." |
| (speaker information will be available at the Conference) |
| 9:30-10:30pm | Session II poster presenters stand by posters |
| 10:30pm | Session II posters come down |