Conference Program
 
COLLAGEN

July 29 - August 3, 2001
Colby-Sawyer College
New London, NH

Chair:
Kari I. Kivirikko

Vice Chair:
Peter Byers

We gratefully acknowledge the financial support from the Gordon Research Conferences and additional support from the following sources:

  • National Institutes of Health
  • The Academy of Finland
  • Shriner's Hospital for Crippled Children
  • FibroGen, Inc.
  • Osteogenesis Imperfect Foundation
  • Children's Brittle Bone Foundation
Sunday, July 29
AfternoonREGISTRATION
4:00 pmRECEPTION
6:00 pmDINNER
7:30 pmOPENING REMARKS, Kari Kivirikko and Peter Byers
Session 1. CELL-MATRIX INTERACTIONS AND SIGNAL TRANSDUCTION IN THE EXTRACELLULAR MATRIX (ECM)
Discussion Leader: Taina Pihlajaniemi, University of Oulu, Finland
7:45 pmShoukat Dedhar, University of British Columbia, Canada
Integrin linked kinase (ILK)
8:20 pmMary M. Zutter, Washington University School of Medicine, St. Louis
alpha 2 beta 1 integrin-dependent regulation of cell phenotype: From man to mouse
8:55 pmJyrki Heino, University of Jyvaskyla, Finland
Integrins and selective recognition of distinct collagen types
9:10 pmWolfgang F. Vogel, Institute for Biomedical Research, Frankfurt, Germany
Employing microarrays to identify downstream targets of DDRs, tyrosine kinase receptors activated by collagen
9:25 pmGeneral discussion
9:30 pmRECEPTION CONTINUED
Monday, July 30
7:30 amBREAKFAST
Session 2. STRUCTURE AND MOLECULAR ASSEMBLY OF COLLAGENS
Discussion Leader: Barbara Brodsky, UMDNJ-Robert Wood Johnson Medical School, Piscataway
9:00 amConference Information
9:10 amBarbara Brodsky: Introduction
9:20 amAnton Persikov, UMDNJ-Robert Wood Johnson Medical School, Piscataway
Basic principles of triple helix conformation and stability
9:50 amLuigi Vitagliano, University of Naples, Italy
The effect of hydroxyproline in triple helix stability and association
10:05 amGROUP PHOTO AND COFFEE BREAK
10:40 amRonald Raines, University of Wisconsin, Madison
Stereoelectronic basis for collagen stability
10:55 amSergei Leikin, National Institute of Health
Triple helix unfolding and refolding in collagen structure, interactions and diseases
11:15 amNeil Bulleid, University of Manchester, U.K.
Maturation of procollagen in the endoplasmic reticulum
11:45 amBilly Hudson, University of Kansas Medical Center, Kansas, KS
Organization and mechanism of chain-specific assembly of type IV collagen networks
12:00 amGeneral discussion
12:30LUNCH
5:00 pmPOSTER SESSION 1 Organized by Peter Byers
6:00 pmDINNER
Session 3:DOMAINS OF COLLAGENS AND OTHER ECM PROTEINS AND THEIR FUNCTIONS
Discussion Leader: Juergen Engel, University of Basel, Switzerland
7:30 pmJuergen Engel, Introduction
7:35 pmRobert Liddington, The Burnham Institute, La Jolla
Matrix-integrin interactions in three dimensions
8:10 pmJohannes Eble, University of Muenster, Germany
Rhodocetin, a novel RGD-independent disintegrin, acts as competitive inhibitor of collagen binding to a2b1 integrin
8:45 pmMunirathinam Sundaramoorthy, University of Kansas Medical Center, Kansas, KS
Molecular interactions governing the chain-specific assembly of type IV collagen networks
9:00 pmCalvin Kuo, Stanford University, Stanford, CA
Motogenic and morphogenic properties of collagen XVIII endostatin domain
9:20 pmGeneral Discussion
9:30 pmPOSTER SESSION 1 CONTINUED
Tuesday, July 31
7:30 amBREAKFAST
Session 4. PROCESSING AND DEGRADATION OF COLLAGENS AND ENZYMES INVOLVED
Discussion Leader: Darwin J. Prockop, Tulane University, New Orleans
9:00 amDarwin J. Prockop: Introduction
9:10 amJohanna Myllyharju, University of Oulu, Finland
Prolyl 4-hydroxylases, the key enzymes of collagen synthesis
9:50 amSergei Boudko, University of Basel, Switzerland
Stabilization and nucleation of the collagen triple helix by a C-terminal oligomerization domain
10:05 amCOFFEE BREAK
10:25 amDaniel Greenspan, University of Wisconsin, Madison
Recent insights into BMP-1 related proteins
11:05 am Matthew P. Leighton, University of Manchester, UK
Studies on the prodomain cleavage of BMP-1
11:20 am David Hulmes, Université Claude Bernard Lyon 1, France
Structure of procollagen C-propeptide trimer and its interaction with procollagen C-proteinase enhancer
11:35 amHenning Birkedal-Hansen, National Institutes of Health, Bethesda, MD
Mechanism of degradation of fibrillar collagens: Fourty years after tadpole collagenase
12:15 amGeneral discussion
12:30LUNCH
6:00 pm DINNER
Session 5: COLLAGENS AND OTHER ECM PROTEINS IN DEVELOPMENT
Discussion Leader: Bjorn R. Olsen, Harvard Medical School, Boston
7:30 pmBjorn R. Olsen: Introduction
7:40 pmNorbert Perrimon, Harvard Medical School, Boston
The role of cell-matrix interactions and integrins during retraction of the germ band in Drosophila embryos
8:15 pmMaria Rita Passos-Bueno, University of Sao Paulo, Brazil
Mutations in collagen XVIII in patients with Knobloch syndrome
8:50 pmShannon Fisher, Johns Hopkins University School of Medicine, Baltimore
Genetic analysis of collagen synthesis and processing in zebrafish skeletogenesis
9:05 pmLinda Sandell, Washington University School of Medicine, St. Louis
Type IIA procollagen N propeptide functions as an antagonist of bone morphogenic proteins
9:20 pmGeneral discussion
Wednesday, August 1
7:30 amBREAKFAST
Session 6.MOUSE MODELS OF THE FUNCTIONS OF COLLAGENS AND OTHER ECM PROTEINS
Discussion Leader: Gerard Karsenty, Baylor College of Medicine, Houston
9:00 amGerard Karsenty: Introduction
9:10 amLauri Eklund, University of Oulu, Finland
Consequences of the lack of type XV and XVIII collagens
9:45 am Joan Marini, National Institutes of Health, Bethesda
The brittle mouse model for non-lethal osteogenesis imperfecta has decreased bone density, bone formation rate and femur strength
10:00 amCOFFEE BREAK
10:20 am Francesco Ramirez, Mt Sinai School of Medicine, New York
Type XIX collagen regulates gastrointestinal function
10:55 amBjorn Olsen, Harvard Medical School, Boston
Vascular endothelial growth factor and skeletal development
11:30 amRaija Soininen, University of Oulu, Finland
Homozygous inactivation of the lysyl oxidase (LOX) gene in mouse leads to a severe cardiovascular dysfunction and perinathal death
11:45 amJames Bristow, University of California San Francisco, San Francisco
Tenascin-X regulates collagen fibril deposition in humans and mice
12:00 amGeneral discussion
12:30LUNCH
5:00 pmPOSTER SESSION 2 Organized by Peter Byers
6:00 pmDINNER
Session 7. NEW COLLAGENS AND OTHER ECM PROTEINS
Discussion Leader: Robert E. Burgeson, Harvard Medical School, Boston
7:30 pmRobert E. Burgeson: Introduction
7:35 pmMarion Gordon, UMDNJ-Robert Wood Johnson Medical School, Piscataway
Collagens and the twenty first century
8:10 pmManuel Koch, Harvard Medical School, Boston
Collagens XXII and XXIV: novel components of tissue junctions
8:45 pm Leena Bruckner-Tuderman, University of Muenster, Germany
Collagen XXII in the hair follicle
9:00 pmVolkhard Lindner, Maine Medical Center, Scarborough
Remodulin, a novel gene modulating collagen matrix
9:15 pmGeneral discussion
9:30 pmPOSTER SESSION 2 CONTINUED
Thursday, August 2
7:30 amBREAKFAST
Session 8.MOLECULAR PATHOLOGY OF COLLAGENS
Discussion Leader: Leena Bruckner-Tuderman, University of Muenster, Germany
9:00 amLeena Bruckner-Tuderman: Introduction
9:10 am.Johanna Pispa, University of Helsinki, Finland
Tumor necrosis factor signalling and ectodermal dysplasia
9:50 amJames Page, University of Washington, Seattle
Defects in the C-propeptide of the proalpha chains of type I procollagen hinder molecular assembly and result in both classical and non-classical variants of osteogenesis imperfecta
10:05 amCOFFEE BREAK
10:30 amMon-Li Chu, Jefferson Medical College, Philadelphia
Type VI collagen defects in Bethlem myopathy
10:55 amTeri Klein, Stanford University, Stanford
Mutational effects on collagen's structure and stability
11:10 amJouni Uitto, Jefferson Medical College, Philadelphia
Molecular genetics of PXE, the prototype of heritable connective tissue diseases
11:45 amRick Wenstrup, Children's Hospital Research Foundation, Cincinnati
A pathogenic mechanism in classical Ehlers-Danlos syndrome (EDS) and partial explanation of the fibril diameter paradox
12:00 amGeneral discussion.
12:30LUNCH
6:00 pmCONFERENCE DINNER
7:30 pmBUSINESS MEETING
Session 9.HOT TOPICS
Discussion Leader: Karl Kadler, University of Manchester, U.K.
7:50 pmKarl Kadler: Introduction
8:00 pmKathryn Chapman, University of Manchester, UK
Mutations in the von Willebrand factor A domain of matrilin-3 result in multiple epiphyseal dysplasia
8:15 pmIchiro Sekiya, Tulane University, New Orleans
Sequential gene expression during differentiation to cartilage of human adult stem cells from bone marrow stroma
8:30 pmJennifer Pierce-Tipper, University of New Mexico, Albuquerque
Regulation of sea cucumber inner dermis compliance properties by tensilin: a TIMP-like protein
8:45 pmKrisztina Rosenberg, University of Lund, Sweden
COMP acts in a chaperone fashion in collagen fibrillogenesis
9:00 pmRussell Fernandes, University of Washington, Seattle
Type II collagen N-propeptide processing by ADAMTS-3. Insights on dermatosparaxis
Friday, August 3
7:30 amBREAKFAST
DEPARTURE
Last Updated: May 4, 2006