| Sunday |
| Epigenetics: Overview of Mechanisms and Evolutionary Roles |
| 7:00 p.m. | Peter Hendel, Holderness Site Manager |
| 7:10 p.m. | Steve Henikoff (Chair), Fred Hutchinson Cancer Center (5 min) |
| 7:15 p.m. | David Haig, Harvard University (25 min; 5 min discussion)
"Remembrance of Things Past: Adaptive Functions of Epigenetic Memory" |
| 7:45 p.m. | Sarah Elgin, Washington University (25 min; 5 min discussion)
"Gene Silencing in Drosophila: An Overview" |
| 8:15 p.m. | Tim Bestor, Columbia University (25 min; 5 min discussion)
"Epigenetic Regulation by DNA Methylation" |
| 8:45 p.m. | Fyodor D. Urnov, Sangamo Biosciences (25 min; 5 min discussion)
"Chromatin Remodeling" |
| 9:15 p.m. | Discussion |
| 9:30 p.m. | Reception |
| Monday |
| Control and Mechanisms of DNA Methylation |
| 8:35 a.m. | Group photo |
| 9:00 a.m. | Eric Selker (Chair) University of Oregon (5 min) |
| 9:05 a.m. | Mitch Turker, Oregon Health Sciences University (15 min; 5 min discussion)
"De novo Methylation and Gene Silencing in Mammals" |
| 9:25 a.m. | En Li, Harvard University (20 min; 5 min discussion)
"Functional Analysis of Mammalian DNA Methyltransferases" |
| 9:50 a.m. | Michael Rountree, Johns Hopkins University (15 min; 5 min discussion)
"DNMT1 and its Protein Partners" |
| 10:10 a.m. | Hisashi Tamaru, University of Oregon (15 min; 5 min discussion)
"Control of DNA Methylation in Neurospora" |
| 10:30 a.m. | Coffee Break |
| 10:55 a.m. | Michael Wassenegger, Fraunhofer Institut (20 min; 5 min discussion)
"Involvement of RNA-Directed DNA Methylation in Post-Transcriptional Plant Gene Silencing" |
| 11:20 a.m. | Marjorie Matzke, Austrian Academy of Sciences (20 min; 5 min discussion)
"Transcriptional Silencing and Promoter Methylation Triggered by Double Stranded RNA" |
| 11:45 a.m. | Bing Zhu, Friedrich Miescher Institute (20 min; 5 min discussion)
"5-methylcytosine DNA Glycosylases, the Link Between DNA Demethylation and Repair" |
| 12:15 p.m. | Discussion (15 min) |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Session #1 |
| 6:00 p.m. | Dinner |
| Imprinting and X Inactivation |
| 7:30 p.m. | Marisa Bartolomei (Chair), University of Pennsylvania (5 min) |
| 7:35 p.m. | Aaron Bowman, Princeton University (20 min; 5 min discussion)
"The Epigenetic Regulation of Genomic Imprinting" |
| 8:00 p.m. | Wolf Reik, The Babraham Institute (20 min; 5 min discussion)
"Epigenetic Control of Silencers: Role in Imprinting" |
| 8:25 p.m. | Stormy Chamberlain, University of Florida (20 min; 5 min discussion)
"Imprinting in the PWS Region" |
| 8:50 p.m. | Coffee Break |
| 9:00 p.m. | Ueli Grossniklaus, University of Zürich (20 min; 5 min discussion)
"Genetic Regulation of Genomic Imprinting in Plants" |
| 9:25 p.m. | Jeannie Lee, Harvard University (20 min; 5 min discussion)
"Epigenetic Effects at the Tsix Locus" |
| 9:50 p.m. | Philip Avner, Pasteur Institut (20 min; 5 min discussion)
"Mechanism of X Inactivation" |
| Tuesday |
| Effects of DNA Methylation |
| 9:00 a.m. | Howard Cedar (Chair) The Hebrew University of Jerusalem (5 min) |
| 9:05 a.m. | Ursula Storb, University of Chicago (20 min; 5 min discussion)
"Ssm1, a Strain Specific Modifier of DNA Methylation" |
| 9:30 a.m. | Brian Hendrich, University of Edinburgh (20 min; 5 min discussion)
"Proteins that Interpret the Methyl-CpG Signal" |
| 9:55 a.m. | Richard Meehan, University of Edinburgh (20 min; 5 min discussion)
"DNA Methylation and Developmental Competence in Xenopus Embryos" |
| 10:20 a.m. | Tetsuji Kakutani, National Institute of Genetics
(20 min; 5 min discussion)
"Developmental Abnormalities Induced by Arabidopsis ddm1 Mutations: Genetic and Epigenetic Bases" |
| 10:45 a.m. | Coffee Break |
| 11:05 a.m. | Eric Richards, Washington University (20 min; 5 min discussion)
"DNA Methylation, Chromatin and Epigenetic Variation" |
| 11:30 a.m. | Steve Jacobsen, University of California, Los Angeles
(20 min; 5 min discussion)
"Genetics of DNA Methylation Patterning in Arabidopsis" |
| 11:55 a.m. | Judith Bender, Johns Hopkins University (20 min; 5 min discussion)
"Mutations that Affect Methylation and Silencing of an Endogenous Gene Family in Arabidopsis" |
| 12:20 p.m. | Discussion (10 min) |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Session #1 |
| 6:00 p.m. | Dinner |
| Chromatin-Based Gene Silencing |
| 7:30 p.m. | Amar Klar (Chair), NCI - Frederick Cancer Research & Development Center
(5 min) |
| 7:35 p.m. | Jim Broach, Princeton University (20 min; 5 min discussion)
"Establishment and Maintenance of Transcriptional Silencing in Saccharomyces" |
| 8:00 p.m. | Robin Allshire, MRC, Western General Hospital, Edinburgh
(20 min; 5 min discussion)
"Centromeric Chromatin of Fission Yeast" |
| 8:25 p.m. | Shiv Grewall, Cold Spring Harbor Laboratory (20 min; 5 min discussion)
"Molecular Mechanism of Epigenetic Inheritance in Fission Yeast" |
| 8:50 p.m. | Coffee Break |
| 9:00 p.m. | Vince Pirotta, University of Geneva (20 min; 5 min discussion)
"Polycomb-Based Repression" |
| 9:25 p.m. | Thomas Jenuwein, The Vienna Biocenter (20 min; 5 min discussion)
"Regulation of Higher Order Chromatin by Histone Methyltransferases" |
| 9:50 p.m. | Lori Wallrath, University of Iowa (20 min; 5 min discussion)
"Conserved Mechanisms of HP1-Mediated Gene Silencing" |
| Wednesday |
| Emerging Epigenetic Phenomena |
| 9:00 a.m. | Denise Barlow, (Chair) Austrian Academy of Sciences (5 min) |
| 9:05 a.m. | Susan Uptain, University of Chicago (25 min; 5 min discussion)
"The yeast prion [PSI+]: an epigenetic modulator of translational termination" |
| 9:35 a.m. | Rick Kelley, Baylor College of Medicine (25 min; 5 min discussion)
"roX RNAs and Dosage Compensation in Drosophila" |
| 10:05 a.m. | Jay Hollick, University of California, Berkeley (15 min; 5 min discussion)
"Genetics of Paramutation" |
| 10:25 a.m. | Maike Stam, University of Arizona (15 min; 5 min discussion)
"Long Distance interactions are required for paramutation and high expression of the maize b1 gene" |
| 10:45 a.m. | Coffee Break |
| 11:05 a.m. | Cho Ting-Wu, Harvard University (15 min; 5 min discussion)
"Transvection: What Do Homologues See in Each Other?" |
| 11:25 a.m. | Robert Metzenberg, Stanford University (25 min; 5 min discussion)
"Silencing of Unpaired Genes in Meiotic Diplophase in Neurospora" |
| 11:55 a.m. | Rodolfo Aramayo, Texas A&M University (15 min; 5 min discussion)
"Genetic and Molecular Analysis of Meiotic Transvection" |
| 12:15 p.m. | Discussion (15 min) |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Session #2 |
| 6:00 p.m. | Dinner |
| Post-Transcriptional Gene Silencing |
| 7:30 p.m. | Andrew Fire (Chair), Johns Hopkins University (5 min) |
| 7:35 p.m. | Darryl Conte, University of Massachusetts Cancer Center
(20 min; 5 min discussion)
"RNA interference in worms" |
| 8:00 p.m. | Ronald Plasterk, The Hubrecht Laboratory (20 min; 5 min discussion)
"Transposon silencing and RNAi in C. elegans" |
| 8:25 p.m. | Coffee Break |
| 8:35 p.m. | Louise K. Jones, John Innes Centre (20 min; 5 min discussion)
"Genetic and Molecular Analysis of RNA Silencing in Plants" |
| 9:00 p.m. | Greg Hannan, Cold Spring Harbor Laboratory (20 min; 5 min discussion)
"dsRNA-induced gene silencing" |
| 9:25 p.m. | Thomas A. Volpe, Cold Spring Harbor Laboratory (20 min; 5 min discussion)
"The Genetics of RNAi in Arbidopsis and S. pombe" |
| 9:50 p.m. | Emma Whitelaw, University of Sydney (20 min; 5 min discussion)
"Epigenetic Inheritance in Mammals" |
| Thursday |
| Epigenomics |
| 9:00 a.m. | Jean Finnegan (Chair), CSIRO (5 min) |
| 9:05 a.m. | Rudolf Jaenisch, MIT (25 min; 5 min discussion)
"Epigenetic reprogramming and the cloning of mice" |
| 9:35 a.m. | Rob Martienssen, Cold Spring Harbor Laboratory (25 min; 5 min discussion)
"Epigenetics and the Plant Genome" |
| 10:05 a.m. | Ortrun Mittelsten Scheid, Friedrich Miescher Institute (25 min; 5 min discussion)
"Genetic Control of Silencing in Plants" |
| 10:35 a.m. | Coffee Break |
| 11:00 a.m. | Rohinten Kamakaka, National Institutes of Health (20 min; 5 min discussion)
"Sir Protein Mediated Silencing in S. cerevisiae" |
| 11:25 a.m. | Pamela Geyer, University of Iowa College of Medicine
(20 min; 5 min discussion)
"The Role of Insulators in Defining Regulatory Interactions" |
| 11:50 a.m. | Welcome Bender, Harvard University (15 min; 5 min discussion)
"Defining Segmental Domains in the Bithorax Complex" |
| 12:10 p.m. | Discussion (15 min) |
| 12:25 p.m. | Lunch |
| 4:00 p.m. | Poster Session #2 |
| 6:00 p.m. | Dinner |
| Epigenetics and Disease |
| 7:30 p.m. | Peter Jones (Chair), University of Southern California (5 min) |
| 7:35 p.m. | Steve Baylin, Johns Hopkins University (20 min; 5 min discussion)
"Epigenetics and Cancer" |
| 8:00 p.m. | Huda Zoghbi, Baylor College of Medicine (20 min; 5 min discussion)
"Molecular Genetics of Rett Syndrome: The Role of MECP2" |
| 8:25 p.m. | Evani Viegas-Pequignot, INSERM (20 min; 5 min discussion)
"ICF Syndrome, An Epigenetic Disease" |
| 8:50 p.m. | Coffee Break |
| 9:00 p.m. | Ben Oostra, Erasmus University (20 min; 5 min discussion)
"Fragile X Syndrome" |
| 9:25 p.m. | Rob Nicholls, University of Pennsylvania (20 min; 5 min discussion)
"Molecular Mechanisms, Genes, Mouse Models, and Evolution of a Large Imprinted Domain Associated with Prader-Willi Syndrome" |