| Sunday, August 12, 2001 |
| 2:00 p.m. - 11:00 p.m. | Arrival & Registration |
| 6:00 p.m. | Dinner |
| Session 1. | Keynote Talks |
| 7:15 p.m. - 7:20 p.m. | Welcome |
| 7:20 p.m. - 7:55 p.m. | Samuel Wilson, National Institute of Environmental Health Sciences, NIH
"Emerging DNA Repair Protein Networks and Implications for Human Health Research" |
| 7:55 p.m. - 8:10 p.m. | Discussion |
| 8:10 p.m. - 8:45 p.m. | Leona Samson, Massachusetts Institute of Technology
"Complex Responses to Alkylating Agents" |
| 8:45 p.m. - 9:00 p.m. | Discussion |
| 9:00 p.m. - 9:35 p.m. | Errol Friedberg, University of Texas Southwestern Medical Center
"Novel DNA Polymerases: Functional Clues Begin to Emerge" |
| 9:35 p.m. - 9:50 p.m. | Discussion |
| Monday, August 13, 2001 |
| 7:30 a.m. | Breakfast |
| Session 2. | Topic: Genotoxicity of Endogenous Lesions |
| 8:45 a.m. - 9:15 a.m. | Chair: Tomas Lindahl, Imperial Cancer Research Center
Introduction and "Accumulation and Repair of Endogenous DNA Damage" |
| 9:15 a.m. - 9:25 a.m. | Discussion |
| 9:25 a.m. - 9:45 a.m. | James Swenberg, University of North Carolina
"Formation and Characterization of AP Sites and Etheno Adducts" |
| 9:45 a.m. - 10:00 a.m. | Discussion |
| 10:00 a.m. - 10:20 a.m. | Conference Photograph |
| 10:20 a.m. - 10:45 a.m. | Coffee Break |
| 10:45 a.m. - 11:05 a.m. | Ben Van Houten, National Institute of Environmental Health Sciences, NIH
"Genotoxicity of Electron Transport Inhibitors: Mitochondrial DNA is a Critical Target for Oxidative Stress" |
| 11:05 a.m. - 11:20 a.m. | Discussion |
| 11:20 a.m. - 11:40 a.m. | Luis Blanco, Universidad Autonoma Madrid
"Pol Lambda and Pol Mu, Two Novel Players in DNA Repair and Mutagenesis in Eukaryotes" |
| 11:40 a.m. - 11:55 a.m. | Discussion |
| 11:55 a.m. - 12:15 a.m. | Harvey Mohrenweiser, Lawrence Livermore National Laboratory
"Common variants in DNA repair genes: Are they cancer susceptibility alleles?" |
| 12:15 a.m. - 12:30 a.m. | Discussion |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Presentations |
| 6:00 p.m. | Dinner |
| Session 3. | Topic: Genotoxicity of Bulky DNA Adducts |
| 7:15 p.m. - 7:45 p.m. | Chair: Philip Hanawalt, Stanford University
Introduction and "Constitutive and Inducible Repair Responses to Bulky DNA Adducts" |
| 7:45 p.m. - 8:00 p.m. | Discussion |
| 8:00 p.m. - 8:20 p.m. | Priscilla Cooper, Lawrence Berkeley National Laboratory
"Pathway Interactions in Transcription-Coupled Repair" |
| 8:20 p.m. - 8:35 p.m. | Discussion |
| 8:35 p.m. - 8:55 p.m. | Lawrence Grossman, The Johns Hopkins University
"Global DNA Repair as a Biomarker of Disease in the Human Population" |
| 8:55 p.m. - 9:10 p.m. | Discussion |
| 9:10 p.m. - 9:30 p.m. | Jan Hoeijmakers, Erasmus University Rotterdam
"In vivo analysis of nucleotide excision repair and transcription" |
| 9:30 p.m.- 9:45 p.m. | Discussion |
| Tuesday, August 14, 2001 |
| 7:30 a.m. | Breakfast |
| Session 4. | Topic: DNA Replication-Dependent Responses |
| 9:00 a.m. - 9:30 a.m. | Chair: Myron Goodman, University of Sourthern California
Introduction and "Biochemical Basis of SOS-induced Error-prone Repair in E. coli: A 'Cowcatcher' Model for Translesion Synthesis Requiring pol V, SSB and RecA" |
| 9:30 a.m. - 9:45 a.m. | Discussion |
| 9:45 a.m. - 10:05 a.m. | Tom Ellenberger, Harvard Medical School
"Exploring Replication Fidelity in Three Dimensions" |
| 10:05 a.m. - 10:20 a.m. | Discussion |
| 10:20 a.m. - 10:45 a.m. | Coffee Break |
| 10:45 a.m. - 11:05 a.m. | Fumio Hanaoka, Osaka University
"XP Variant Gene and Protein" |
| 11:05 a.m. - 11:20 a.m. | Discussion |
| 11:20 a.m. - 11:40 a.m. | Bradley Preston, University of Utah
"DNA Replication Fidelity and Cancer" |
| 11:40 a.m. - 11:55 a.m. | Discussion |
| 11:55 a.m. - 12:15 a.m. | Michael Christman, University of Virginia
"The TRF4 DNA Polymerase Couples Replication to the Establishment of Sister Chromatid Cohesion" |
| 12:15 a.m. - 12:30 a.m. | Discussion |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Presentations |
| 6:00 p.m. | Dinner |
| Session 5. | Topic: DNA Mismatch Repair-Dependent Responses to Genotoxins |
| 7:15 p.m. - 7:45 p.m. | Chair: Richard Fishel, Kimmel Cancer Center
Introduction and "Mismatch Repair in a Brownian Universe" |
| 7:45 p.m. - 8:00 p.m. | Discussion |
| 8:00 p.m. - 8:20 p.m. | Wei Yang, Natl. Inst. Diabetes and Digestive and Kidney Diseases, NIH
"A Tale of Two ATPases and DNA Mismatch Repair" |
| 8:20 p.m. - 8:35 p.m. | Discussion |
| 8:35 p.m. - 8:55 p.m. | Winfried Edelmann, Albert Einstein College of Medicine
"Genetic Analysis of the Murine MMR System" |
| 8:55 p.m. - 9:10 p.m. | Discussion |
| 9:10 p.m. - 9:30 p.m. | Mark Meuth, University of Sheffield
"Cellular consequences of loss of mismatch repair" |
| 9:30 p.m. - 9:45 p.m. | Discussion |
| Wednesday, August 15, 2001 |
| 7:30 a.m. | Breakfast |
| Session 6 | Topic: Replication Blockage and its Consequences |
| 9:00 a.m. - 9:30 a.m. | Chair: Michael Resnick, National Institute of Environmental Health Sciences, NIH
Introduction and "Double-Strand Breaks and Replication: The Ends Are in Sight" |
| 9:30 a.m. - 9:45 a.m. | Discussion |
| 9:45 a.m. - 10:05 a.m. | Tom Petes, University of North Carolina
"Double-Strand DNA Breaks in Meiotic and Mitotic Yeast Cells" |
| 10:05 a.m. - 10:20 a.m. | Discussion |
| 10:20 a.m. - 10:45 a.m. | Coffee Break |
| 10:45 a.m. - 11:05 a.m. | Carl Anderson, Brookhaven National Laboratory
"DNA-PK and p53: Caretakers and Guardians of Genomes" |
| 11:05 a.m. - 11:20 a.m. | Discussion |
| 11:20 a.m. - 11:40 a.m. | Maria Jasin, Sloan-Kettering Institute
"Genomic Integrity and Double-Strand Break Repair in Mammalian Cells" |
| 11:40 a.m. - 11:55 a.m. | Discussion |
| 11:55 a.m. - 12:15 a.m. | Bevin Engelward, Massachusetts Institute of Technology
"Mechanisms of Base Damage-Induced Homologous Recombination" |
| 12:15 a.m. - 12:30 a.m. | Discussion |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Presentations |
| 6:00 p.m. | Dinner |
| 7:00 p.m. - 7:30 p.m. | Business Meeting |
| Session 7 | Topic: Responses to DNA Strand Breaks |
| 7:15 p.m. - 7:45 p.m. | Chair: Penelope A. Jeggo, University of Sussex
Introduction and "Patients Defective in DNA Ligase IV" |
| 7:45 p.m. - 8:00 p.m. | Discussion |
| 8:00 p.m. - 8:20 p.m. | John Tainer, The Scripps Research Institute, UCSD
"Structurally-Encoded Conformational Switching in Base-Excision and Double-Strand Break Repair: Raising the Induced Fit Paradigm from Enzymes to DNA Repair Pathways" |
| 8:20 p.m. - 8:35 p.m. | Discussion |
| 8:35 p.m. - 8:55 p.m. | Tanya Paull, University of Texas at Austin
"Enzymatic Activities of the Mre11/Rad50/Nbs1 Complex in DNA Double-Strand Break Repair" |
| 8:55 p.m. - 9:10 p.m. | Discussion |
| 9:10 p.m. - 9:30 p.m. | Marianne Berwick, Sloan-Kettering Cancer Center
"The Current Epidemiology of Double-Strand Break Repair: A Paradigm of Genotype-Phenotype Correlation and Challenge for the Future" |
| 9:30 p.m. - 9:45 p.m. | Discussion |
| Thursday, August 16, 2001 |
| 7:30 a.m. | Breakfast |
| Session 8 | Topic: Genome Instability/Mutagenesis |
| 9:00 a.m. - 9:30 a.m. | Chair: Robert Fuchs, C.N.R.S. Ecole Supérieure de Biotechnologie de Strasborg
Introduction and "Competition Among DNA Polymerases During Translesion Synthesis" |
| 9:30 a.m. - 9:45 a.m. | Discussion |
| 9:45 a.m. - 10:05 a.m. | Roel Schaaper, National Institute of Environmental Health Sciences, NIH
"UvrB-bio Deletions in E. coli and Salmonella: Excision Repair and Other Defects" |
| 10:05 a.m. - 10:20 a.m. | Discussion |
| 10:20 a.m. - 10:45 a.m. | Coffee Break |
| 10:45 a.m. - 11:05 a.m. | Kyungjae Myung, Ludwig Institute for Cancer Research, UCSD
"Multiple Pathways Cooperate in Suppressing Genome Instability in S. cerevisiae" |
| 11:05 a.m. - 11:20 a.m. | Discussion |
| 11:20 a.m. - 11:40 a.m. | Mitch Turker, Oregon Health Sciences University
"An In Vivo Model for Radiation Induced Genomic Instability" |
| 11:40 a.m. - 11:55 a.m. | Discussion |
| 11:55 a.m. - 12:15 a.m. | Robert Heflich, National Center for Toxicological Research
"Mutation Detection in the Mouse Using the Endogenous, Autosomal Tk Gene" |
| 12:15 a.m. - 12:30 a.m. | Discussion |
| 12:30 p.m. | Lunch |
| 4:00 p.m. | Poster Presentations |
| 6:00 p.m. | Dinner |
| Session 9 | Topic: Toxicogenomics |
| 7:15 p.m. - 7:45 p.m. | Chair: Richard Paules, National Institute of Environmental Health Sciences, NIH
Introduction and "Interrogation of Mechanisms Underlying Cellular Responses to Environmental Stresses Using Global Gene Expression Analyses" |
| 7:45 p.m. - 8:00 p.m. | Discussion |
| 8:00 p.m. - 8:20 p.m. | Albert Fornace, National Cancer Institute, NIH
"Functional Genomics and Informatics Approaches to Categorize Radiation Responses" |
| 8:20 p.m. - 8:35 p.m. | Discussion |
| 8:35 p.m. - 8:55 p.m. | Cloud Paweletz, US Food and Drug Administration
"Beyond the Genome to Tissue Proteomics: Insights into Mechansisms of Human Carcinogenesis" |
| 8:55 p.m. - 9:10 p.m. | Discussion |
| 9:10 p.m. - 9:30 p.m. | Douglas A. Lauffenburger, Massachusetts Institute of Technology
"Cell Decision Processes: A Bioengineering Approach to Cell Signaling & Responses" |
| 9:30 p.m. - 9:45 p.m. | Discussion |
| Friday, August 17, 2001 |
| 7:30 a.m. | Breakfast |