| Sunday |
| Welcome |
| Announcements |
| Evening: 7:30-9:30 | Role of cell-cell communications in hormonal carcinogenesis |
| Chair: Dipak Sarkar, Rutgers University |
| 1. | Dipak Sarkar, Professor, Rutgers University
A new role for follicular-stellate cells in controlling pituitary prolactin-secreting tumors. |
| 2. | Jerry Cunha, Professor, University of California at San Francisco
New models of hormonal carcinogenesis of the prostate. |
| 3. | Steven Byers Professor, Georgetown University
Mesenchymal cadherins and breast cancer. |
| 4. | Mark Sternlicht, Postdoctoral Fellow. University of California, San Francisco
How stromal metalloproteinases regulate the development and progression of epithelial cancers. |
| Monday |
| Breakfast |
| Conference Photo |
| Morning: 9:00-12:30 | Genomic approaches to hormonal carcinogenesis |
| Chair: Bennett Van Houten, NIEHS |
| 1. | Bennett Van Houten, NIEHS |
| 2. | Christopher Bradfield, University of Wisconsin
Genomic and genetic approaches to understand tumor promotion in liver |
| 3. | Spyro Mousses, National Human Genome Research Institute
Highly parallel gene expression analysis of therapy response and therapy failure in prostate cancer |
| Coffee Break |
| 1. | Ed Clark, Millenium
Identification of genomic markers to predict response to chemotherapy |
| 2. | Allan Ferguson, Rosetta Inpharmatics
Identification of toxicity pathways through gene expression analysis |
| 3. | Late breaking presentation(s) (Selected from abstracts) |
| Lunch |
| Afternoon: 4:00-6:00 | Poster and poster discussion sessions |
| Evening: 7:30-9:30 | Non-genomic Action(s) of Estrogens and Progestins |
| Chair: Johne Liu, University of Ottawa |
| 1. | Richard Santen, University of Virginia
Effect of estrogen non-genomic pathways on MCF-7 cell growth regulation: Involvement of Src, Shc, and MAPK |
| 2. | Jin Chen, Johns Hopkins University |
| 3. | Johne Liu, University of Ottawa
Regulation of Xenopus oocyte meiosis arrest G protein beta-gamma subunits |
| 4. | Late breaking presentation(s) (Selected from abstracts) |
| |
| Tuesday |
| Nominations for 2003 Vice Chair |
| Morning: 9:00-12:30 | Dietary factors in hormonal carcinogenesis |
| Co-Chair: William Helferich, University of Illinois |
| Co-Chair: Coral Lamartiniere, University of Alabama |
| Overview of session: William Helferich |
| 1. | Leena Hilakivi-Clarke, Lombardi cancer Center, Georgetown University
Genestein exposure during pregnancy and breast cancer risk in mother and her female offspring. |
| 2. | William Helferich, University of Illinois
Dietary genestein and estrogen-dependent breast cancer growth. |
| Coffee Break |
| 3. | Sari Makela, University of Turku, Turku, Finland
Regulation of prostatic growth by genestein. |
| 4. | Coral Lamartiniere, University of Alabama at Birmingham
Genestein chemoprevention: Timing of exposure and mechanisms of action in mammary and prostate. |
| 5. | Late breaking presentation (Selected from abstracts) |
| Lunch |
| Afternoon: 4:00-6:00 | Poster and poster discussion sessions |
| Evening: 7:30-9:30 | Clinical consequences of hormonally active dietary supplements |
| Co-Chair: Robert DiPaola, UMDNJ-Robert Wood Johnson Medical School, Cancer Institute of New Jersey |
| Co-Chair: Kathleen Shiverick, University of Florida |
| 1. | Kathleen Shiverick, University of Florida
Identification of novel targets for prostate cancer prevention and treatment using gene targeting. |
| 2. | Robert DiPaola, Cancer Institute of New Jersey
Effects of dietary supplements on prostate cancer |
| 3. | Late breaking presentation (Selected from abstracts) |
| Wednesday |
| Election of 2003 Vice Chair |
| Morning: 9:00-12:30 | Molecular modeling in prostate cancer |
| Chair: Gail Prins, University of Illinois |
| Co-chair: Maarten Bosland, New York University |
| 1. | John DiGiovanni, MD Anderson Cancer Center
IGF-1 and prostate cancer |
| 2. | Michael Weber, University of Virginia
Signal transduction and prostate cancer progression |
| Coffee Break |
| 3. | Maarten Bosland, NYU
Effects of perinatal androgen exposure on growth and carcinogenesis in rat prostate |
| 4. | Gail Prins, Univ. of Illinois
Estrogen effects on retinoic acid signaling in the rat prostate gland |
| 5. | Late breaking presentation (Selected from abstracts) |
| Lunch |
| Afternoon: 4:00-6:00 | Poster and poster discussion sessions |
| Evening: 7:30-9:30 | Gene-environment interactions in hormonal consequences |
| 1. | Cheryl Walker, MD Anderson Cancer Center
Ligand and tissue-specific transactivation of gene activation by xenoestrogens |
| 2. | David Sassoon, Mt. Sinai School of Medicine
Role of Wnt genes in the female reproductive tract: Requirement for the estrogen response |
| 3. | Late breaking presentation (Selected from abstracts) |
| Thursday |
| Morning: 9:00-12:30 | Role of PPAR and other "non-steroid" receptors in hormonal carcinogenesis |
| Chair: Robert Brueggemeier, Ohio State University |
| Co-Chair: Steven Safe, Texas A and M University |
| Introduction to session: Rob't. Brueggemeier |
| 1. | Shiuan Chen City of Hope, LaJolla, CA.
Regulation of breast tissue aromatase by nuclear orphan receptors. |
| 2. | Michael Kilgore University of Kentucky
Role of PPARs in breast cell growth regulation. |
| Coffee Break |
| 3. | Steven Safe, Texas A&M University
Interaction of ERa and the aryl hydrocarbon receptor in breast cancer. |
| 4. | Michelle Tabb Univ. of California, Irvine
SXR, a novel target for breast cancer prevention and treatment. |
| 5. | Late breaking session (Selected from abstracts) |
| Lunch |
| Afternoon: 4:00-6:00 | Poster and poster discussion sessions |
| Conference Banquet |
| Evening: 7:30-9:30 | Keynote |
| Kenneth Korach, NIEHS
Revisiting an olde question in DES toxicity carcinogenesis
|
| Open Discussion |