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| 2-11 p.m. | Arrival, registration and check-in |
| 5-6 p.m. | Welcome Reception |
| 6 p.m. | Dinner |
| Sunday Evening | New Aspects of the Biological Chemistry of Nitric Oxide |
|
| Moderator: Shirley Luckhart |
| 7:30-7:45 p.m. | Joseph S. Beckman, Ph.D.
Introductory Comments and Welcome |
| 7:45-8:10 p.m. | Rafael Radi, Ph.D., University of the Republica, Montevideo, Uruguay.
Advances in the biological chemistry of nitric oxide and peroxynitrite |
| 8:10-8:30 p.m. | Discussion |
| 8:30-8:55 p.m. | Leonid Moroz, Ph.D., University of Florida.
Evolution of nitric oxide signaling in simpler nervous systems |
| 8:55-9:15 p.m. | Discussion |
| Monday Morning | Advances in Understanding Nitric Oxide Synthesis |
|
| Moderators: Owen Griffith and Christian Schöneich |
| 7:30-8:00 a.m. | Breakfast |
| 8:30-9:00 a.m. | Conference Photograph |
| 9:00-9:25 a.m. | C. S. Raman, Ph.D., Univ. Texas Houston, TX.
Structure, function, and evolutionary history of prokaryotic ancestral nitric oxide synthases. |
| 9:25-9:45 a.m. | Discussion |
| 9:45-10:10 a.m. | Ton Gorren, University of Graz, Austria
Role of biopterin in the synthesis of nitric oxide. |
| 10:10 -10:30 a.m. | Discussion |
| 10:30-11:00 a.m. | Coffee Break |
| 11:00-11:25 a.m. | Dennis Stuehr, Ph.D., Cleveland Clinic, OH.
Developing a kinetic model to explain catalysis and regulation in NOS |
| 11:25-11:45 a.m. | Discussion |
| 11:45-12:10 p.m. | John Parkinson, Ph.D.*, Berlex Biosciences, CA
Novel strategies to inhibit cytokine-inducible NOS |
| 12:10-12:30 p.m. | Discussion |
| 12:30-1:30 p.m. | Lunch |
| Afternoons are open for discussion |
| 4:30-6:00 p.m. | Poster session |
| 6:00 p.m. | Dinner |
| Monday Evening | Cellular Consequences of Nitrosative and Nitrative Stress |
|
| Moderator: Rafael Radi |
| 7:30-7:55 p.m. | Tony Thompson, UAB, Birmingham, AL.
Acidic FGF and reactive nitrogen species in wound healing and angiogenesis |
| 7:55-8:15 p.m. | Discussion |
| 8:15-8:40 p.m. | Peter Dedon, MIT, Boston, MA.
DNA damage by peroxynitrite and nitric oxide. |
| 8:40-9:00 p.m. | Discussion |
| Tuesday Morning | Heme Proteins, Superoxide and Reactive Nitrogen Species |
|
| Moderator: Stan Hazen |
| 7:30-8:30 a.m. | Breakfast |
| 9:00-9:25 a.m. | Yoichi Osawa, Univ. Michigan, Ann Arbor, MI.
Heme insertion, assembly, and activation of neuronal NOS synthase. |
| 9:25-9:45 a.m. | Discussion |
| 9:45-10:10 a.m. | Susanna Herold, ETH Zurich, Switzerland.
Mechanistic studies of the reactions of NO and peroxynitrite with oxyhemoglobin |
| 10:10-10:30 a.m. | Discussion |
| 10:30-11:00 a.m. | Coffee Break |
| 11:00-11:25 a.m. | Mark Quinn, Montana State University.
NADPH oxidase in immune and nonimmune cells |
| 11:25-11:45 a.m. | Discussion |
| 11:45-12:10 p.m. | Masuko Ushio-Fukai, Ph.D., Emory University.
Functions of NADPH Oxidase in the vasculature |
| 12:10-12:30 p.m. | Discussion |
| 12:30-1:30 p.m. | Lunch |
| Afternoons are open for discussion |
| 4:00-5:30 p.m. | Hot Topics |
| 4:30-6:00 p.m. | Poster session |
| 6:00 p.m. | Dinner |
| Tuesday Evening | Nitric Oxide and Apoptosis |
|
| Moderator: Jonathan Stamler |
| 7:00-7:30 p.m. | Business Meeting |
| 7:30-7:55 p.m. | Joan Mannick, M.D. U. Massachusetts Medical Center, Shrewsbury, MA.
Protein S-Nitrosylation in mitochondria. |
| 7:55 -8:15 p.m. | Discussion |
| 8:15-8:40 p.m. | Alvaro Estevez, UAB, Birmingham, AL.
Contrasting actions of nitric oxide in motor neuron death in ALS |
| 8:40-9:00 p.m. | Discussion |
| Wednesday Morning | Nitric Oxide and Hemoglobin |
|
| Moderators: Jack Lancaster and Steve Gross |
| 7:30-8:30 a.m. | Breakfast |
| 9:00-9:25 a.m. | Rakesh Patel, Ph.D.* UAB, Birmingham, AL
Modulatory effects of heme oxygenation state on SNOHb vasoactivity |
| 9:25-9:45 a.m. | Discussion |
| 9:45-10:10 a.m. | Jonathan Stamler, M.D., Duke University, Durham, NC.
Models based on Hemoglobin |
| 10:10-10:30 a.m. | Discussion |
| 10:30-11:00 a.m. | Coffee Break |
| 11:00-11:25 a.m. | Mark Gladwin, M.D., NIH, Bethesda, MD.
S-Nitrosation versus iron nitrosylation in the circulation. |
| 11:25-11:45 a.m. | Discussion |
| 11:45-12:10 p.m. | David Singel, Montana State Univ., Bozeman, MT.
Nitric oxide heme interactions. |
| 12.10-12:30 p.m. | Discussion |
| 12:30-1:30 p.m. | Lunch |
| Afternoons are open for discussion |
| 4:30-6:00 p.m. | Poster session |
| 6:00 p.m. | Dinner |
| Wednesday Evening | Peroxidases and Peroxynitrite |
|
| Moderator: Harry Ischiropoulos |
| 7:30-7:55 p.m. | Stanley Hazen, Cleveland Clinic, OH.
Reactions of peroxidases with nitrite and nitric oxide |
| 7:55-8:15 p.m. | Discussion |
| 8:15-8:40 p.m. | Sara Goldstein, Ph.D., Hebrew University, Israel.
A radical view of peroxynitrite and tyrosine nitration. |
| 8:40-9:00 p.m. | Discussion |
| Thursday Morning | Targets of Reactive Nitrogen Species in Pathophysiology |
|
| Moderators: LeeAnn MacMillan-Crow and Joe Beckman |
| 7:30-8:30 a.m. | Breakfast |
| 9:00-9:25 a.m. | Volker Ullrich, University of Konstanz, Germany.
Nitration and inactivation of prostacyclin synthase |
| 9:25-9:45 a.m. | Discussion |
| 9:45-10:10 a.m. | Harry Ischiropoulos, University of Pennsylvania.
Protein Tyrosine Nitration and Parkinson's disease |
| 10:10-10:30 a.m. | Discussion |
| 10:30-11:00 a.m. | Coffee Break |
| 11:00-11:25 a.m. | Christian Schöneich, University of Kansas.
Inactivation of Serca-II calcium ATPases by reactive nitrogen species |
| 11:25-11:45 a.m. | Discussion |
| 11:45-12:10 p.m. | Serpil Erzurum, Ph.D., Cleveland Clinic, OH.
Nitric oxide chemical events in the human airway during the immediate and late antigen-induced asthmatic response |
| 12:10-12:30 p.m. | Discussion |
| 12:30-1:30 | Lunch |
| Afternoons are open for discussion |
| 4:30-6 | Poster Session |
| Thursday Evening | Mitochondrial Nitric Oxide |
|
| Moderator: Victor Darley-Usmar |
| 6:00-7:30 p.m. | Banquet |
| 7:30-7:55 p.m. | Cecilia Giulivi, Univ. Minnesota, Duluth, MN.
Nitric oxide and mitochondria. |
| 7:55-8:15 p.m. | Discussion |
| 8:15-8:40 p.m. | Tony Kanai, Univ. Pittsburgh, PA.
Direct measurement of nitric oxide production in isolated mitochondria. |
| 8:40-9:00 p.m | Discussion |