|
| 7:20 pm | Welcome and Administrative issues |
| Session 1. | Cellular models of Oxidative stress |
|
| Discussion Leader - J. S. Valentine (UCLA) |
| 7:30 pm | J. S. Valentine
"Copper, SOD, and ALS" |
| 8:00 pm | J. P. Crow (University of Alabama)
"Role of Zinc and Copper in SOD1-Mediated Toxicity" |
| 8:30 | Plenary Lecture:
B. Halliwell (National University of Singapore)
"Adventures with hydrogen peroxide in nutrition and Neuroscience |
| 9:30 pm | End of Day 1. |
|
| 9:00 am Session 2 | Oxidative stress and neurodegeneration |
|
| Discussion Leader: R.H. Brown (Harvard Medical School) |
| 9:10 am | M.F. Beal (Cornell University)
"Oxidative Damage in ALS and HD pathogenesis" |
| 9:40 am | M.P. Mattson (National Institute of Aging/Johns Hopkins University)
"Mechanisms of Oxidative Stress-Induced Apoptosis and Excitotoxicity in neurodegenerative Disorders" |
| 10:10-10:30 am | Break |
| 10:30 am | T.M Dawson (Johns Hopkins University)
"Unraveling of the mechanisms of oxidative stress-induced neurodegeneration" |
| 11:00 am | Group photo |
| 11:30 am | D.W. Cleveland (UCSD)
"Toxicity of superoxide dismutase mutants in Lou Gehrig's disease: testing the oxidative hypothesis in neurodegeneration" |
| 12:00 pm | Short Talk:
Tom O'Halloran:
"Copper Chaperone/SOD1 Interactions in ALS: Roles of Oxidation and Protein Aggregation States." |
| 12:30 pm | Lunch |
| Afternoon Free |
| 4-6 pm | Poster Session 1, Refreshments sponsored by Mitokor |
| 6-7:30 pm | Dinner |
| 7:00 pm Session 3 | Oxidative stress and Apoptosis |
|
| Discussion Leader: D. Nicholls (Buck Institute for Age Research) |
| 7:30 pm | J.H.M Prehn (IZKF, Germany)
"Role of Superoxide Production and Caspase Activation in Apoptosis: More than one way to kill a cell" |
| 8:00 pm | A. Murphy (Mitokor)
"Probing the Mechanisms of Mitochondrial Reactive Oxygen Species Production and Cytochrome c Release" |
| 8:30 pm | D. Nicholls (Buck Institute for Age Research)
"Monitoring mitochondrial membrane potential in dying neurons" |
| 9:00 pm | S. Passarella (Molise University, Italy)
"Mitochondria and oxidative stress" |
| 9:30 pm | End of Day 2. |
|
| 9:00 am Session 4. | Oxidative stress and the Cardiovascular and Pulmonary systems |
|
| Discussion Leader - B. A. Freeman (UAB) |
| 9:10 am | J.D. Crapo (National Jewish Medical Research Institute)
"EC-SOD and SOD mimetics in modulating intracellular signaling and oxidative stress" |
| 9:40 am | D.S. Warner (Duke University)
"Catalytic Antioxidants and the Injured Brain" |
| 10:10-10:40 am | Break |
| 10:40 am | J. Hickman-Davis (UAB)
"Nitric oxide derived reactive species in infectious lung disease: specific mechanisms and consequences" |
| 11:10 | J. P. Eiserich (UC Davis)
"Heme peroxidases are bifunctional nitric oxide and nitrite oxidases: Physiologic and pathophysiological implications for nitric oxide signaling" |
| 11:40 pm | Short Talk:
J. Friedman:
"Pathogenesis and Therapy of Sideroblastic Anemia: Insights from a Murine Model Utilizing SOD2 Deficient Stem Cells." |
| 12:30 pm | Lunch |
| Afternoon Free |
| 4-6 pm | Poster Session 2, Refreshments sponsored by deCode Genetics |
| 6-7:30 pm | Dinner |
| 7:30 pm Session 5 | Oxidative stress and Alzheimers Disease |
|
| Discussion Leader - G. Perry (Case Western Reserve University) |
| 7:30 pm | A. I. Bush (Harvard Medical School)
"Abeta oxidation activity in Alzheimer's disease: problem and remedy" |
| 8:00 pm | C. Behl (Max Planck Institute, Germany)
"Oxidative stress in Alzheimer's Disease and Neuroprotection - Estrogens as Neuroprotectants" |
| 8:30 pm | L.M. Sayre (Case Western Reserve University)
"Protein side-chain oxidation and adduction in oxidative stress" |
| 9 pm | G. Perry (Case Western Reserve University)
"Oxidative stress and responses in Alzheimer disease" |
| 9:30 pm | End of Day 3. |
|
| 9:00 am Session 6. | Oxidative stress and metabolic disease |
|
| Discussion Leader - T. Rouault (NICHD) |
| 9:00 am | R.E. Fleming (St. Louis University School of Medicine)
"Hepatic Iron Loading: Lessons from a Murine Model of Hereditary Hemochromatosis" |
| 9:30 am | A.H. Schapira (Royal Free and University College Medical School, London)
"Mitochondrial respiratory chain defects, oxidative stress and human disease" |
| 10:00 -10:30 am | Break |
| 10:30 am | T. Rouault (NICHD)
"Misregulation of iron metabolism and neurodegenerative disease in mice that lack iron regulatory protein 2" |
| 11:00 am | L Harris (St. Louis Childrens Hospital)
"The role of multi-copper oxidases in disease" |
| 11: 30 am | V. Culotta (Johns Hopkins University)
"SOD, oxidative damage and the mitochondria: new insights from yeast" |
| 12:30 pm | Lunch |
| Afternoon Free |
| 4-6 pm | Poster Session 3. Refreshments sponsored by Mitokor and deCode Genetics |
| 6-7:30 pm | Dinner |
| 7:30 pm Session 7. | Mouse models of Oxidative stress |
|
| Discussion Leader - C. J. Epstein (UCSF) |
| 7:30 pm | T.T. Huang (UCSF)
"Differential sensitivity to oxidative stress in MnSOD mutant mice on different genetic backgrounds" |
| 8:00 pm | J. A. Andersen (Buck Institute for Age Research)
"Iron, Glutathione and Parkinson's Disease" |
| 8:30 pm | Z. Xu (University of Mass. Medical School)
"Mitochondrial damage is an early step in mutant SOD1-induced motoneuron degeneration in ALS" |
| 9:00 pm | M. Gurney (deCode Genetics, Iceland)
"Mutant Cu,Zn SOD, Oxidative Stress and Motor Neuron Disease" |
| 9:30 pm | End of Day 4. |
|
| 9:00 am Session 8. | Aging and Oxidative stress |
|
| Discussion Leader - J. Tower (USC) |
| 9:00 am | J. Tower (USC)
"Manipulating Drosophila oxidative stress resistance and life span with inducible transgenic systems" |
| 9:30 am | J. Phillips (University of Guelph, Canada).
"Anoxic paralysis, membrane channels and lifespan: three faces of reactive oxygen biology in Drosophila" |
| 10:00-10:30 am | Break |
| 10:30 am | G. R. Lithgow (Buck Institute for Age Research)
"C. elegans ageing and oxidative stress - a mechanistic relationship?" |
| 11:00 am | A.R. Richardson (University of Texas Health Science Center, San Antonio)
"Using Transgenic/Knockout Mice to Study the Oxidative Stress Theory of Aging" |
| 11:30-11:45 am | Short talk.
C. Clarke
"A Dietary Source of Coenzyme Q is Essential for Growth of Long-lived C. elegans clk-1 Mutants" |
| 11:45-12:00 pm | Short talk
T. Shirasawa
"Mitochondrial Respiratory Dysfunction in Clk-1/Coq7-deficient Mice" |
| 12:00 -12:30 pm | Business meeting and election of Vice Chair for 2003 GRC on Oxidative stress and disease |
| 12:30 pm | Lunch |
| Afternoon Free |
| 6-7:30 pm | Dinner |
| 7:30 pm Session 9 | Special Plenary Lecture |
|
| Discussion leader - V. Culotta |
| I. Fridovich (Duke University)
"Cu, Zn SOD: Superoxide Dismutase; Superoxide Reductase; and Bicarbonate Peroxidase" |
| Session 10. | Oxidative stress and Therapeutics |
|
| Discussion Leader - A.I. Bush |
| 8:30 pm | L.L. Dugan (Washingon University School of Medicine)
"C60 fullerene compounds as Neurotherapeutics" |
| 9:00 pm | S.R. Doctrow (Eukarion)
"Salen-Manganese complexes: combined SOD/Catalase mimics with broad pharmacological efficacy" |
| 9:30 pm | End of Conference |