Conference Program
 
TUBERCULOSIS DRUG DEVELOPMENT

June 24-29, 2001
Colby-Sawyer College
New London, NH

Chairs:
Clifton E. Barry & Ken Duncan


We would like to gratefully acknowledge financial contributions from the following:

  • GlaxoSmithKline
  • AstraZeneca Research Foundation India
  • Eli Lilly and Company
  • The Global Alliance for TB Drug Development

Session 1.
(Sunday PM)
Defining the need for new antituberculars
Discussion Leader: Ariel Pablos-Mendez (The Rockefeller Foundation, NY, USA)
  • Chris Dye (World Health Organization, Geneva, Switzerland)
    "The global epidemiology of tuberculosis, and the potential impact of new drugs"
  • Rick O'Brien (Centers for Disease Control, Atlanta, USA)
    "The need for new TB drugs: obstacles and opportunities"
Session 2.
(Monday AM)
Target Selection & Rational Design
Discussion Leader: Ken Duncan (GlaxoSmithKline, UK)
  • Patrick Brennan (Colorado State University, Ft. Collins, USA)
    "A Multi-Institutional TB Drug Discovery Program Based on Fundamental Principles of Mycobacterium tuberculosis Cell Wall Biosynthesis"
  • James Sacchettini (Texas A&M University, USA)
    "Structure-based design of drugs that target enzymes in fatty acid synthesis and degradation"
  • John Blanchard (AECOM, USA)
    "Enzymes of Mycobacterial Amino acid and Cofactor Biosynthesis as Potential Targets."
  • Issar Smith (Public Health Research Institute, NY)
    "Mycobacterium tuberculosis interactions with host macrophages"
Session 3.
(Monday PM)
Clinical Issues in the Evaluation of New Antituberculars
Discussion Leader: Bernard Fourie (MRC, South Africa)
  • Kathy Eisenach (University of Arkansas, Little Rock, AK, USA)
    "The use of surrogate markers of drug efficacy in the clinical evaluation of novel antimycobacterial agents"
  • Charles Peloquin (National Jewish Hospital, Denver, USA)
    "TB Drug Delivery and Drug Interactions"
  • Robert Wallace (UMDNJ Med School, NJ)
    "A whole blood bactericidal assay for tuberculosis"
Session 4.
(Tuesday AM)
Screening and Lead Compound Identification
Discussion Leader: John Lonsdale (GlaxoSmithKline, US)
  • Martin Everett (GlaxoSmithKline, UK)
    "Target development and lead identification."
  • Denis Mitchison (St. George's Hospital Medical School, London)
    "Selection for sterilising activity"
  • Barbara Laughon (NIAID, USA)
    "NIAID screening resources for drug discovery"
  • Richard Lee (University of Tennessee, Memphis)
    "Synthesis and evaluation of diamine libraries as new tuberculosis chemotherapies"
Session 5.
(Tuesday PM)
Latency and TB Drug Development
Discussion Leader: Ken Stover (PathoGenesis/Chiron, USA)
  • David Russell (Cornell University, USA)
    "Plumbing the environment within the infected phagocyte"
  • Joanne Flynn (University of Pittsburgh, USA)
    "The challenges of using animal models to study latent tuberculosis"
  • Galina Mukamolova (Bach Institute of Biochemistry, Moscow)
    "Rpg-like growth factors from mycobacterium tuberculosis"
Session 6.
(Wednesday AM)
Animal Models for Assessing Drug Efficacy
Discussion Leader: David McMurray (Texas A&M University, USA)
  • Jacques Grosset (Groupe Hospitalier Pitie-Salpetriere, Paris)
    "Compared with the standard first line antituberculosis drugs-rifampin, isoniazid, pyrazinamide, streptomycin, ethambutol-, which new drugs have in the mouse model a promising efficacy?"
  • Ian Orme (Colorado State University, Ft. Collins, USA)
    "Aerosol infection models for testing drugs in vivo"
  • Bala Subramanian (AstraZeneca, India)
    "Efficacy of Anti-TB Compounds:A Pre-Clinical R&D Experience"
  • Anthony Hickey (UNC, Chapel Hill)
    "Aerosol delivery of drugs to the lungs: implications for tuberculosis therapy"
Session 7.
(Wednesday PM)
Drug Resistance Mechanisms
Discussion Leader: Clif Barry (NIH)
  • Valerie Mizrahi (South African Instit. Med. Res., Johannesburg, RSA)
    "Acids and fatty acids: Relevance to the mode of action of pyrazinamide"
  • William R. Jacobs, Jr. (AECOM, USA)
    "The mechanism of action of isoniazid: A proverb of blind men and an elephant."
  • Peter Tonge (SUNY Stony Brook)
    "Mechanism of action of isoniazid"
Session 8.
(Thursday AM)
Medicinal Chemistry
Discussion Leader: Michael Hearn (Wellsley College, USA)
  • Paul Wyatt (GlaxoSmithKline, UK)
    "Thiolactomycin: the rocky road from lead to clinical candidate"
  • John Welch (SUNY, Albany, USA)
    "Chemical Modification of Pyrazinamide; A Tool for New Insights into an Old Drug."
  • Stephen Gillespie (Royal Free, London)
    "Engineering molecules to solve clinical problems."
  • Ramesh Panchagnula (NIPER, India)
    "Rifampicin: revisited"
Session 9.
(Thursday PM)
Emerging Genome-Scale Tools for Drug Discovery
Discussion Leader: Stewart Cole (Institute Pasteur, Paris)
  • Mike Wilson (NIAID, RTB, USA)
    "Microarray platforms and tactics for analyzing gene expression profiles"
  • Ruth McAdam (GlaxoSmithKline, UK)
    "Saturation transposon mutagenesis and proteomics to prioritize therapeutic targets in TB"
  • Ted Baker (Auckland, New Zealand)
    "From ORFs to protein structures to drugs: a consortium approach to the structural genomics of TB"
  • Calvin Boon (Institute of Molecular and Cell Biology, Singapore)
    "Proteins of mycobacterium bovis BCG induced in the Wayne Dormancy Model"

Last Updated: May 4, 2006