Conference Program
 
ENVIRONMENTAL ENDOCRINE DISRUPTORS

July 14-19, 2002
Mount Holyoke College
South Hadley, MA

Chair:
Ana M. Soto

Vice Chair:
Daniel M. Sheehan

The next Gordon Research Conference on Environmental Endocrine Disruptors will be held on July 14-19, 2002, at Mt. Holyoke College in South Hadley, Massachusetts.

ABSTRACT: Humans and wildlife are exposed to a large number of widely used environmental chemicals known or suspected to have either estrogenic or antiandrogenic activities, or to interfere with thyroid hormone action. Wildlife studies strongly suggest that populations are severely affected by these environmental endocrine disruptors (EEDs) in a number of ways (dysfunctional endocrine and reproductive systems, altered behavior, malformations, and thus reduced reproduction and population numbers). EEDs are also thought to cause malformations of the human genital tract as well as testicular and breast cancers. These findings have alerted the scientific community, governments worldwide, and the general public to the harm likely to be caused by EEDs. The US and Japanese governments and the European Union are gathering information, funding large research efforts, and in some cases, enacting laws regulating EEDs. In the US, amendments to the Safe Drinking Water Act and the Food Quality Protection Act mandate testing of EED activities for chemicals found in water and food.

THE SITE: Mt. Holyoke is a small liberal arts college located in a picturesque town in the beautiful Berkshire Mountains of Western Massachusetts. Both the lecture hall and lodging facilities are modern and comfortable. Hiking in the nearby Berkshire Mountains is easily accessible. Other activities include tennis (indoor and outdoor), canoeing, "championship" golf course (on campus), an arboretum, swimming, racquetball, basketball, volleyball, squash, softball, indoor and outdoor tracks, and a well-equipped fitness center. For those who wish to prolong their stay in the area, cultural activities include Tanglewood, the summer home of the Boston Symphony Orchestra in nearby Lee, MA. The Conferences site can be easily reached by flying into Boston, Hartford, or New York.


SUNDAY
7:30-9:30 pmPanel Discussion: Evolution, Development and Endocrine Disruptors
7:30Introductory remarks: Ana Soto
Discussion leader: Carlos Sonnenschein, Tufts University, Boston, MA
Scott Gilbert, Swarthmore College, Swarthmore, PA
Ecological Developmental Biology meets the real world.
Joe Thornton, Columbia University, New York, NY
Evolution of steroid hormone receptors.
General discussion
MONDAY
8:45Photo
9:00 a.m.-12:30 pmDioxins and Development
Discussion Leader: Paolo Mocarelli, University Milano-Bicocca, Milan, Italy
Jodi A. Flaws, University of Maryland School of Medicine, Baltimore, MD
What the Ah knockout teaches us about ovarian physiology.
Linda Birnbaum, Environmental Protection Agency, Research Triangle Park, NC
Prenatal exposure to dioxins alter the development of the mammary gland.
Coffee break
Sandra Petersen, University of Massachusetts, Amherst, MA
Dioxin and the development of the neuroendocrine system: from genes to behavior.
General Discussion: From knockouts to epidemiology: Fleshing out a hypothesis that explains the effects of dioxins.
7:30-9:30 pmPerspectives on Endocrine Disruptor Research
Discussion Leader: Daniel M. Sheehan
Gary Timm, Environmental Protection Agency, Washington, DC
A view from EPA
Jerry Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC
A view from NIEHS
Willie Owens, Proctor and Gamble, Cincinnati, OH
A perspective from industry
TUESDAY
8:45 am-12:30 pmImpact of Endocrine Disruptors on the Male Genital Tract
Discussion Leader: Bernard Jegou, Universite de Rennes, France
Gen Yamada, Kumamoto University, Kumamoto Japan
Do endocrine disruptors cause hypospadias? Molecular analysis of external genital formation.
Rex Hess, University of Illinois, Urbana, IL
A role for estrogens in the male reproductive system: the impact of xenoestrogens.
Niels Skakkebaeck, University of Copenhagen, Denmark
Alterations of the male genital tract and testicular cancer: are they due to endocrine disruptor exposure?
Coffee break
Luis F. Parada, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
A molecular basis for estrogen-induced cryptorchidism.
7:30-9:30 pmMechanisms Underlying the Effects of Xenoestrogens: Receptors and homeobox genes
Discussion Leader: George Stancel, University of Texas Health Sciences Center, Houston, TX
Sari Mäkelä, University of Turku, Finland
The yin and yang of estrogen action
Takeshi Kurita, University of California, San Francisco, CA
Epithelium-stroma interactions in the development of the female genital tract.
David Sassoon, Mount Sinai Medical School
Endocrine disruption of homeobox and wnt genes in the female genital tract.
WEDNESDAY
9:00 am-12:30 pmChemical Mixtures in Endocrine Disruption in Human Populations
Discussion Leader: Louis Guillette, University of Florida, Gainsville FL
Marieta Fernandez, University of Granada, Granada, Spain
Biomarkers of exposure for mixtures and their use to test exposure in humans.
Shanna H. Swan, University of Missouri, Columbia MO
Can exposure to currently used agricultural chemicals explain rural-urban differences in semen quality?
Coffee break
Andreas Kortenkamp, The School of Pharmacy, Centre for Toxicology London, England
Assessment of the effects of mixtures of xenoestrogens.
7:30-9:30 pm.Endocrine Disruptors, Development and Neoplasia
Discussion Leader: Annie Sasco, International Agency for Research on Cancer, Lyons France
Caroline Markey, Tufts University, Boston, MA
Perinatal exposure to low levels of bisphenol-A alters the development of the mouse mammary gland.
Retha Newbold, National Institute of Environmental Health Sciences, Research Triangle Park, NC
Phytoestrogens as carcinogens
General discussion
THURSDAY
9:00 am -12:30pm.Endocrine Disruption in Wildlife
Discussion Leader: Anne McNabb, Virginia Polytechnic Institute and State University, Blacksburg VA
John G. Burkhart, National Institute of Environmental Health Sciences, Research Triangle Park, NC
Complex interactions in aquatic environments associated with amphibian malformations and decline.
Susan Jobling, Brunnel University, UK
Effects of endocrine disruptors in prosobranch mollusks.
Coffee break
Gary Ankley, Environmental Protection Agency, Duluth, MN
linking endocrine disruption, environmental chemistry and policy using wildlife models.
7:30-9:30 pmDisruptors of Thyroid Function
Discussion Leader: Tom Zoeller, University of Massachusetts, Amherst, MA
Donald Pfaff, Rockefeller University, New York, NY
Two modes of estrogen actions in nerve cells and their relation to transcriptional disruption by liganded thyroid hormone receptors.
Daniel Doerge, National Center for Toxicological Research, Jefferson, AR
Effects of soy isoflavones on thyroid function.
Closing Remarks: Ana M. Soto
 
This conference is supported by the NIEHS, NSF and EPA.

Last Updated: May 4, 2006