| Sunday |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm | Replication and initiation of meiotic recombination |
| Discussion Leader: JoAnne Engebrecht |
| Scott Keeney, Sloan-Kettering Institute, New York
Double-strand break formation in yeast and mouse: Spo11 and its partners |
| Michael Lichten, National Cancer Institute (10 min)
Chromosome structure/function and the initiation of meiotic recombination |
| Alain Nicolas, Institut Curie, Paris (10 min)
Targeted meiotic recombination and association of Mre11 to DSB regions in S. cerevisiae |
| Silvia Prieler / Franz Klein, University of Vienna (10 min)
Interaction of Spo11 with recombination hotspots for an extended period of time requires at least three genes in S. cerevisiae. |
| Mathilde Grelon, Institut National de la Recherche Agronomique-France
Isolation and characterization of genes essential for Arabidopsis thaliana meiosis |
| Kim McKim, Waksman Institute and Rutgers University (10 min)
Regulation of DSB formation and repair by components of the Drosophila synaptonemal complex |
| Randy Strich, Fox Chase Cancer Center, Philadelphia (10 min)
Block to re-replication in meiotic cells |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Nuclear reorganization during early meiotic prophase |
| Discussion Leader: Denise Zickler |
| Yasushi Hiraoka, Kansai Advanced Research Center, Kobe, Japan
Regulation of telomere clustering by pheromone signaling |
| Harry Scherthan, Max Planck Institute for Molecular Genetics, Berlin, Germany
Meiotic chromosome behaviour in response to altered ploidy and heterochromatin integrity |
| Zac Cande, University of California, Berkeley
Genetic and Cytological Analysis of Early Prophase Events in Maize |
| Anne Villeneuve, Stanford University School of Medicine
Coordinating changes in chromosome and nuclear organization with crossover recombination in C. elegans |
| Graham Moore, John Innes Research Institute, U.K
The Ph1 system in wheat |
| Julio Vazquez, UCSF (10 min)
The dynamics of homologous chromosome pairing during male Drosophila meiosis |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm | Recombination mechanisms and pathways |
| Discussion Leader: Doug Bishop |
| Karl-Peter Hopfner, University of Munich
Structure of the Rad50-Mre11 complex in recombination and repair |
| John Petrini, Sloan-Kettering Institute, New York
A hypomorphic Mre11 mutant in the mouse |
| Jeff Sekelsky, University of North Carolina, Chapel Hill (10 min)
A complex containing MEI-9 (the XPF/Rad1 homolog) and MUS312 (a novel
protein) acts to generate meiotic crossovers in Drosophila |
| James Haber, Brandeis University
Molecular mechanisms of mitotic and meiotic recombination |
| Neil Hunter, Harvard University/UC Davis (10 min)
Imposition and implementation of the crossover decision |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Regulation of meiotic recombination |
| Discussion leader: Scott Keeney |
| Douglas Bishop, University of Chicago
Ends Apart: Evidence for Synthesis-Dependent Strand Annealing and the Role of Checkpoint Genes in Regulating Recombination. |
| Akira Shinohara, Osaka University, Japan
The roles of RecA homologs and DNA damage checkpoint proteins in meiotic recombination and crossover control |
| Nancy Kleckner, Harvard University
Chiasma formation via linked parallel pathways of changes at the DNA and axis levels. |
| Alastair Goldman, University of Sheffield, U.K.
Examining 5´ to 3´ resection during meiosis |
| Bernard de Massy, Institut de Genetique Humaine, CNRS, Montpellier, France
Direct detection, mapping and timing of meiotic recombination in mice |
| Paula Cohen, Albert Einstein College of Medicine (10 min)
Meiotic arrest in MutL homolog3 (Mlh3) Null Mice |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm | Homolog juxtaposition and synapsis |
| Discussion Leader: Steven Stack |
| Sean Burgess, University of California, Davis
Close, stable homolog juxtaposition in meiosis of budding yeast: The prominent role of recombination |
| Beth Rockmill, Yale University (10 min)
The crossover defect in ZIP1 mutants is suppressed when chromosome axes interact |
| Scott Hawley, The Stowers Institute, Kansas City
Genetic Analysis of SC Formation and Function in Drosophila |
| Miriam Zolan, Indiana University
The role of the Coprinus cinereus adherin Rad9 in DNA repair, meiotic sister chromatid cohesion, and meiotic homolog pairing |
| Dan Camerini-Otero, Genetics and Biochemistry Branch, NIDDK, NIH (10 min)
The role of the mouse Hop2/TBPIP protein in homologous chromosome pairing |
| Bruce McKee, University of Tennessee (10 min)
Identification of two genes required for homolog pairing in Drosophila male meiosis |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Condensation, cohesion and axis morphogenesis |
| Discussion leader: Nancy Kleckner |
| Tatsuya Hirano, Cold Spring Harbor Laboratories, NY
Establishing metaphase chromosome structure |
| Denise Zickler, Université Paris-Sud
Initiation of meiotic recombination and sister chromatid cohesiveness |
| Christer Hoog, Karolinska Institute, Stockholm, Sweden
The role of SCP3 in female and male meiosis |
| Christa Heyting, Wageningen University, Netherlands
Assembly and disassembly of the axial elements of synaptonemal complexes |
| Barbara Meyer, University of California, Berkeley
Cohesion and recombination of meiotic chromosomes in C. elegans |
| Sharon Bickel, Dartmouth College (10 min)
Regulation of meiotic sister-chromatid cohesion in Drosophila |
| 12:30 pm | Lunch |
| 1:30 pm | Workshop: Interference - How and Why?
This will be an informal discussion, led by Frank Stahl, where interference aficionados can get together with an easel/whiteboard/blackboard to talk about how interference might work. All comers are welcome to present their ideas, BUT: Chalk-talk format only; no slides or powerpoint. |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm | Chromosome segregation |
| Discussion leader: Terry Orr-Weaver |
| Gary Karpen, Salk Institute
Centromeric Chromatin in Flies and Humans |
| Kirsten P. Rabitsch, Research Institute of Molecular Pathology, Vienna (10 min)
Mono-orientation of sister kinetochores during meiosis I requires two proteins involved in rDNA silencing |
| Fernando Pardo-Manuel de Villena, University of North Carolina, Chapel Hill
Unexpected properties of the meiotic spindle: Nonrandom segregation of chromosomes |
| Jose Suja, Universidad Autónoma de Madrid, Spain
Centromere organization during mammalian meiotic divisions |
| Yoshinori Watanabe, University of Tokyo (10 min)
Cohesion complexes distinct at centromere and arm in meiosis of fission yeast |
| Chris Makaroff, Miami University, Ohio (10 min)
The Arabidopsis SYN1 Cohesin Protein is Required for Meiotic Chromosome Arm Cohesion From Early Prophase to Anaphase I |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Meiotic Progression |
| Discussion leader: Scott Hawley |
| Terry Orr-Weaver, Whitehead Institute at M.I.T.
Separation of sister chromatids in Drosophila |
| Masayuki Yamamoto, Tokyo University
Stabilization of meiotic messages during meiosis in fission yeast |
| Margaret Fuller, Stanford University School of Medicine
Prophase regulation of meiotic cell cycle progression and gamete differentiation |
| Terry Ashley, Yale University
The Mammalian Mid-pachytene Checkpoint: Why is it there? |
| Oscar Fernandez-Capetillo, National Cancer Institute (10 min)
Meiotic Failure in Histone H2AX deficient mice |
| Hong Ma, Pennsylvania State University (10 min)
Molecular genetic analysis of meiotic chromosome segregation in Arabidopsis |
| David Greenstein, Vanderbilt University
An Eph Receptor Sperm-Sensing Control Mechanism for Oocyte Meiotic Maturation in C. elegans |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm | "Sex: How and Why?" |
| Discussion leader: Anne Villeneuve |
| Steven Stack, Colorado State University
A model for chromosome structure during the mitotic and meiotic cell cycles |
| David Page, Whitehead Institute at M.I.T.
Rethinking the Rotting Y Chromosome |
| Patrick Shiu, Stanford University
Meiotic Silencing by Unpaired DNA |
| John Logsdon, Emory University (10)
Origins and evolution of the meiotic machinery in protists |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |