| Sunday, July 21 |
| 2:00 - 9:00 PM | Registration |
| 6:00 PM | Dinner |
| SESSION 1 | "Metal Generated Radicals & Photodynamic Therapies" |
| Session Chair: John T. Groves (Princeton University) |
| 7:40 - 7:50 PM | Welcome from Chair & GRC |
| 7:50 - 8:00 PM | Introductory comments, Session Chair |
| 8:00 - 8:30 PM | Andrew L. Salzman (Inotek Corp.)
"Medical Applications of Peroxynitrite Decomposition Catalysts" |
| 8:40 - 9:30 PM | Keynote Speaker, Jonathan L. Sessler (University of Texas, Austin)
"Biomedical Applications of Expanded Porphyrins" |
| 9:45 - PM | Chair's Reception |
| Monday, July 22 |
| 7:30 - 8:30 AM | Breakfast |
| SESSION 2 | "Metalloproteins in Disease" |
| Session Chair: Joan S. Valentine (UCLA) |
| 9:00 - 9:15 PM | Introductory comments, Session Chair |
| 9:15 - 9:45 AM | Ashley I. Bush (Massachusetts General Hospital, Boston)
"Beta-Amyloid Metalloprotein as a Therapeutic Target for Alzheimer's Disease" |
| 10:00 - 10:15 AM | Coffee Break / Photo |
| 10:15 - 10:45 AM | Michael A. Marletta (Cal-Berkley)
"Metal-dependent Repressors as Targets for Nitric Oxide" |
| 10:55 - 11:25 AM | P. John Hart (University of Texas, Health Science Center at San Antonio)
"X-ray Analyses of CuZnSOD in Familial Amyotrophic Lateral Sclerosis" |
| 11:35 - 12:05 PM | Susan R. Doctrow (Eukarion, Inc.)
"Salen Manganese Complexes as Catalytic Scavengers of Reactive Oxygen Species with Protective Activity in Models for Diseases Involving Oxidative Stress" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| SESSION 3 | "Metalloproteins as Targets" |
| Session Chair: Thomas J. Meade (Northwestern University) |
| 7:35 - 7:50 PM | Introductory comments, Session Chair |
| 7:50 - 8:20 PM | William G. Rice (Achillion Pharmaceuticals, Inc.)
"Zinc Finger Proteins as Targets for Anti-infective Therapy" |
| 8:30 - 9:00 PM | Richard C. Holz (Utah State University)
"A Novel Antibiotic Target: The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae" |
| 9:10 - 9:40 PM | Casey C. Case (Sangamo BioSciences, Inc.)
"Controlling Gene Expression using Engineered Zinc Finger Proteins" |
| Tuesday, July 23 |
| 7:30 - 8:30 AM | Breakfast |
| SESSION 4 | "Radiopharmaceuticals" |
| Session Chairs: Alan Davison (MIT) & Alan Packard (Children's Hospital, Boston) |
| 8:45 - 9:00 PM | Introductory comments, Session Chair |
| 9:00 - 9:30 AM | Shuang Liu (Bristol-Myers Squibb, Co.)
"Small Molecule Radiopharmaceuticals Derived from Pharmaceutical Leads" |
| 9:40 - 10:10 AM | Silvia S. Jurisson (University of Missouri-Columbia)
"Rh-105 Complexes as Potential Therapeutic Radiopharmaceuticals" |
| 10:20 - 10:40 AM | Coffee Break |
| 10:40 - 11:10 AM | Jacquelyn C. Yanch (MIT)
"The use of boron in the treatment of rheumatoid arthritis" |
| 11:20 - 11:50 PM | David A. Scheinberg (Memorial Sloan Kettering Cancer Center)
"Therapeutic Uses of Nanogenerators of Radiometals" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| SESSION 5 | "MRI Agents" |
| Session Chair: Randall B. Lauffer (Epix Medical, Inc.) |
| 7:35 - 7:50 PM | Introductory comments, Session Chair |
| 7:50 - 8:20 PM | Silvio Aime (University of Torino)
"Exploring New Routes to Improve the Contrast Enhancing Ability of Paramagnetic Agents in Cellular MRI" |
| 8:30 - 9:00 PM | A. Dean Sherry (University of Texas at Dallas)
"Lanthanide Complexes with Slow Water Exchange May Offer Advantages in the Design of Functional MR Agents" |
| 9:10 - 9:40 PM | Peter Caravan (EPIX Medical)
"Targeted Molecular Imaging with MRI" |
| Wednesday, July 24 |
| 7:30 - 8:30 AM | Breakfast |
| SESSION 6 | "Metal Complexes & Parasites" |
| Session Chair: Vijay Sharma (Washington University, St. Louis) |
| 8:45 - 9:00 PM | Introductory comments, Session Chair |
| 9:00 - 9:30 AM | Gary Posner (Johns Hopkins University)
"Antimalarial Peroxides Triggered by Ferrous Iron" |
| 9:40 - 10:10 AM | D. Scott Bohle (University of Wyoming)
"Malaria Pigment/Antimalarial Drug Interactions" |
| 10:20 - 10:40 AM | Coffee Break |
| 10:40 - 11:10 AM | David W. Wright (Vanderbilt University)
"Hemozoin, Immunosuppression and Cerebral Malaria: Mechanisms for Clinical Therapies" |
| 11:20 - 11:50 PM | Maribel Navarro (IVIC, Venezuela)
"Metal Complexes as Potential Chemotherapeutic Agents against parasitic diseases" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 3 |
| 6:00 pm | Dinner |
| SESSION 7 | "Transport and Targeting of Metal Ions" |
| Session Chair: Peter J. Sadler (University of Edinburgh) |
| 7:35 - 7:50 PM | Introductory comments, Session Chair |
| 7:50 - 8:20 PM | Douglas Pfeiffer (Ohio State University)
"The Ionophore Monensin Mediates a Rapid and Selective Transport of Pb2+ in Model and Biological Systems: Possible Application of Monensin for the Treatment of Pb2+ Intoxication" |
| 8:30 - 9:00 PM | Hongzhe Sun (University of Hong Kong)
"Bismuth and Antimony Recognition by Peptides and Proteins: Implications for Transport and Targeting" |
| 9:10 - 9:40 PM | Gérard Jaouen (Ecole Nationale Supérieur de Chimie de Paris)
"Targeting Organometallic Complexes onto Hormone Receptors. Therapeutic Applications" |
| Thursday, July 25 |
| 7:30 - 8:30 AM | Breakfast |
| SESSION 8 | "Beneficial & Deleterious Effects of Transition Metal Ions" |
| Session Chair: Debbie C. Crans (Colorado State University) |
| 8:45 - 9:00 PM | Introductory comments, Session Chair |
| 9:00 - 9:30 AM | Chris Orvig (University of British Columbia)
"In Vivo Coordination Chemistry: Biolocalization of Insulin-Enhancing Vanadium Complexes" |
| 9:40 - 10:10 AM | John B. Vincent (University of Alabama)
"New Advances in the Biochemistry of Cr(III)" |
| 10:20 - 10:40 AM | Coffee Break |
| 10:40 - 11:10 AM | Peter A. Lay (University of Sydney)
"New Insights into the Genotoxicity of Chromium" |
| 11:20 - 11:50 PM | Paul J. Kostyniak (SUNY, Buffalo)
"The Importance of Chemical Form in Determining the Pharmacokinetic and Pharmacodynamic Actions of a Metal: The Case of Mercury" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 5:30 pm | Group Business Meeting |
| 6:00 pm | Banquet |
| SESSION 9 | "Metal Ion - Nucleic Acid Interactions" |
| Session Chair: Trevor Hambley (University of Sydney) |
| 7:35 - 7:45 PM | Comments from Co-Chairs |
| 7:45 - 8:15 PM | Introductory comments, Session Chair |
| 8:25 - 9:15 PM | Capstone Lecture, Stephen J. Lippard (MIT)
"Structure, Recognition, and Functional Consequences of Platinated DNA" |
| 9:30 PM | Closing remarks from Chair |
We extend our appreciation to Anormed, EPIX and NIH for their support of this conference.
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