| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE TALKS |
| Discussion Leader: Pam Cowin (NYU) |
| 7:30 pm - 8:10 pm | James Nelson (Stanford)
"Mechanics of Adhesion Between Simple Epithelial Cells" |
| 8:10 pm - 8:50 pm | Mina Bissell (Lawrence Berkeley Lab)
"Extracellular matrix-induced polarity as a central regulator of gene expression, apoptosis resistance, and cancer in the mammary gland" |
| 8:50 pm - 9:30 pm | Barry Gumbiner (U. Virginia)
"Cadherins and Catenins in Development and Cancer" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | CELL CONTACTS AND THE REGULATION OF STEM CELL SURVIVAL AND CELL FATE DETERMINATION |
| Discussion Leader: Rolf Kemler (MPI, Freiburg) |
| 9:00 am - 9:40 am | Roel Nusse (Stanford)
"Wnt-Frizzled Signaling During Development" |
| 9:40 am - 10:20 am | Rolf Kemler (MPI, Freiburg)
"E-Cadherin Conditional Gene Inactivation During Mouse Development" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Colin Jamora (Fuchs Lab, Rockefeller U.)
"Regulation of Adhesion Dynamics During Morphogenesis" |
| 11:10 am - 11:50 am | Elisabetta Dejana (FIRC, Milan)
"Cadherin and Catenin Signaling in the Development of the Vascular System" |
| 11:50 am - 12:30 pm | Gerald Grunwald (Thomas Jefferson U)
"Mechanisms of cadherin subtype switching during ocular development: Now you see 'em, now you don't" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELL ADHESION IN MAMMARY GLAND DEVELOPMENT AND CANCER |
| Discussion Leader: Zena Werb (UCSF) |
| 7:30 pm - 8:10 pm | Zena Werb (UCSF)
"MMPs: Janus-Like Regulators of Branching Morphogenesis" |
| 8:05 pm - 8:35 pm | Sarah Hatsell (Cowin Lab, NYU)
"Catenins in Mammary Progenitor Cells" |
| 8:35 pm - 9:00 pm | Caroline Alexander (McArdle Lab, U. Wisconsin)
The Heparan Sulfate Syndecan-1 is Required to Create a Wnt-responsive Mammary Epithelial Sub-population. |
| 9:00 pm - 9:30 pm | Rachel Hazan (Albert Einstein)
"A complex of the FGF receptor and N-cadherin controls tumor metastasis |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELL CONTACT AND EPITHELIAL MORPHOGENESIS: ASYMMETRIC CELL DIVISION, PLANAR POLARITY AND CELL MIGRATION
|
| Discussion Leader: Denise Montell (Johns Hopkins) |
| 9:00 am - 9:35 am | Francois Schweisguth (CNRS)
"Regulation of Epithelial Polarity During Asymmetric Cell Division" |
| 9:35 am - 10:10 am | Marek Mlodzik (Mt Sinai Sch. of Med.)
"Wnt/Frizzled Signaling in Epithelial Planar Cell Polarization" |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 11:10 am | Denise Montell (Johns Hopkins)
"Genetic Control of E-Cadherin Mediated Border Cell Migration In Drosophila" |
| 11:10 am - 11:50 am | Michael Simon (UCSF)
"Fat and Dachsous in Planar Polarity Control of Planar Cell Polarity and Proliferation by Atypical Cadherins" |
| 11:50 am - 12:30 pm | Jeff Hardin (Madison)
"Roles of Adherens Junctions Complex in Worms" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ADHESION STRUCTURES AND SIGNALING |
| Discussion Leader: Martin Hemler (Dana Farber Cancer Institute) |
| 7:30 pm - 8:00 pm | Tim Springer (Harvard)
"Recent Developments in Integrin Activation" |
| 8:00 pm - 8:30 pm | Bill Weis (Stanford)
"Structural and Biochemical Studies of Molecular Interactions in Adherens Junctions and Desmosomes" |
| 8:30 pm - 9:00 pm | David Stokes (Skirball Institute)
"Electron Tomographic Reconstruction of Desmosomes" |
| 9:00 pm -9:30 pm | Alexander Koch (Mt Sinai, NY)
"Structure of the N-cadherin prodomain: New insights into an activation mechanism of cell adhesion"
|
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELL CONTACT AND EPITHELIAL MORPHOGENESIS II: POLARITY |
| Discussion Leader: W. James Nelson (Stanford) |
| 9:00 am - 9:40 am | Elisabeth Knust (U. Dusseldorf)
"Crumbs and Stardust in Cell Polarity" |
| 9:40 am - 10:20 am | Ulli Tepass (U. Toronto)
"Genetic Analysis of Cadherin Function in Flies" |
| 10:20 am - 11:00 pm | Ben Margolis (U. Michigan)
"Protein-protein interaction domains and cell polarity" |
| 11:00 am - 11:30 am | Coffee Break |
| 11:30 am - 12:30 pm | ALEXANDER M CRUICKSHANK SPEAKER:
Eric Wieschaus (Princeton)
"Adhesive Junctions and Epithelial Morphogenesis in Drosophila" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time / Optional Workshop |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ADAPTORS TRANSDUCERS AND CYTOSKELETAL ORGANIZERS |
| Discussion Leader: Mary Beckerle (U. Utah) |
| 7:30 pm - 8:00 pm | Sandra Citi (U. Geneva)
"Analysis of double mutant embryoid bodies indicates a scaffolding function for the tight junction protein cingulin" |
| 8:00 pm - 8:30 pm | Martin Hemler (Dana Farber)
"Modulation Of Integrin Functions By Associated Proteins" |
| 8:30 pm - 9:00 pm | Mary Beckerle (U. Utah)
"Roles Of LIM Proteins at Sites of Actin-Membrane Anchorage" |
| 9:00 pm - 9:30 pm | Al Reynolds (Vanderbilt U.)
"P120-Catenin: Metastasis Promoter or Tumor Suppressor?" |
| Business Meeting: Election of 2005 Vice Chair |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIGNALING, PROLIFERATIVE CONTROL AND CANCER |
| Discussion Leader: Walter Birchmeier (Max Delbrueck Center, Berlin) |
| 9:00 am - 9:35 am | Mike Klymkowsky (Boulder U. Colorado)
"SOX Modulation of Beta-Catenin Signaling and Cell
Differentiation" |
| 9:35 am - 10:10 am | Walter Birchmeier (Max Delbrueck Center, Berlin)
"New Components Involved In Epithelial Mesenchymal Transitions And Metastasis" |
| 10:10 am -10:30 am | Coffee Break |
| 10:30 am - 11:05 am | Mark Peifer (UNC)
"Cell Adhesion, Signal Transduction And Cancer: The Armadillo Connection" |
| 11:05 am - 11:35 am | David Rimm (Yale)
"Cell Biology to Tissue Microarrays: Met and Beta-catenin in Cancer" |
| 11:30 am - 12:00 am | Otmar Huber (Freie Universität Berlin)
Modulation of LEF/TCF-ß-catenin transcriptional activity |
| 12:00 am - 12:30 am | Sumayah Jamal (NYU)
"Caspase-8 Dependent Downregulation of E-cadherin and Beta-Catenin in Melanocytes and Melanoma Cells by Endothelin-1" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm |
HOT TOPICS |
| Discussion Leader: Gerald Grunwald (Thomas Jefferson University) |
| Anna Bafico (Mount Sinai School of Medicine)
"Novel mechanisms of canonical Wnt signaling in human cancer cells" |
| Anthony Brumby (Peter MacCallum Cancer Institute)
"Cooperative tumorigenesis in Drosophila: Disruption of epithelial polarity cooperates with oncogenic Ras to cause neoplastic overgrowth" |
| Rachel Brewster (CIWEMB)
"The zebrafish bumpy brain mutation implicates desmoglein function in neurulation" |
| Cara Gottardi (U. Virginia)
"Biochemically distinct pools of ß-catenin interact with cadherin and TCF: Implications for Wnt signaling, adhesion, and cadherin-mediated tumor suppression" |
| Jerry Rhee (Arizona State University)
"Rho signaling mediates mouse somite epithelialization" |
| 9:10 pm | Gerald Grunwald (Thomas Jefferson U)
"Closing Remarks and Future Perspectives" |
| |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |