| SUNDAY |
| 2:00 - 9:00 | Arrival and Check-in |
| 6:00 | Dinner |
| 7:30-7:35 | Welcoming remarks:
Chair, Val Culotta |
| 7:35-9:30 | Oxidative Stress and Aging I |
| Discussion Leader - Bruce Freeman (U. Alabama at Birmingham, USA) |
| 7:35 - 7:50 | Introduction to session: Bruce Freeman |
| 7:50 - 8:30 | Bruce Ames (U. California Berkeley, USA)
"Delaying the mitochondrial decay of aging" |
| 8:30 - 8:40 | Discussion |
| 8:40 - 9:20 | Earl Stadtman (NIH, USA)
"Methionine sulfoxide reductase as a genetic determinant of aging" |
| 9:20 - 9:30 | Discussion |
| 9:30 - 11:00 | Chair's Reception |
| MONDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Oxidative Stress and Aging II |
| Discussion Leader - Cynthia Kenyon (U. California San Francisco, USA) |
| 9:00 - 9:15 | Introduction to session: Cynthia Kenyon |
| 9:15 - 9:40 | Leonard Guarente (MIT, Boston, USA)
"Sir2, oxidative Damage and aging" |
| 9:40 - 9:50 | Discussion |
| 9:50 - 10:15 | Catherine Clarke (U. California, Los Angeles, USA)
"Co-enzyme Q and life span in C. elegans" |
| 10:15 - 10:25 | Discussion |
| 10:25 - 10:50 | Siegried Hekimi (McGill University, Montreal, Canada)
"Molecular mechanism of action of mutations in the clk-1 gene of C. elegans" |
| 11:50 - 11:00 | Discussion |
| 11:00 - 11:35 | Coffee Break and Group Photo |
| 11:35 - 12:00 | Toshinori Hoshi (U. Pennsylvania, Philadelphia, USA)
"Methionine oxidation in regulation of aging and neuronal excitability" |
| 12:00 - 12:10 | Discussion |
| 12:10 - 12:30 | Shawn Flanagan (U. Iowa, USA)
"Cytoprotective role of the copper chaperone in a mutant SOD1-model of ALS" |
| 12:30 | Lunch |
| 4:00 - 6:00 PM | Poster session |
| 6:00 | Dinner |
| 7:30 - 9:30 | Mitochondria and oxidative damage |
| Discussion Leader - Douglas Wallace (U. California, Irvine, USA) |
| 7:30 - 7:45 | Introduction to session: Douglas Wallace |
| 7:45 - 8:10 | Martin Brand (MRC, Cambridge, UK)
"Effect of superoxide on mitochondrial uncoupling proteins" |
| 8:10 - 8:20 | Discussion |
| 8:20 - 8:45 | Valina Dawson (Johns Hopkins University, Baltimore, USA)
"Nuclear-Mitochondrial Cross-Talk in Experimental Stroke and Parkinson's disease" |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:20 | William Woodruff (Los Alamos Natl Lab, USA)
"The Scale of Things: Allometric Scaling in Bioenergetics and Related Processes" |
| 9:20 - 9:30 | Discussion |
| TUESDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Reactive oxygen and pathogenecity |
| Discussion leader - Jim Imlay (U. Illinois, Urbana, USA) |
| 9:00 - 9:15 | Introduction to session: Jim Imlay |
| 9:15 - 9:40 | Ferric Fang (U. Washington, Seattle, USA)
"Pumping Iron by FieA: A New Twist in Bacterial Iron Metabolism and Susceptibility to Reactive Oxygen Species" |
| 9:40 - 9:50 | Discussion |
| 9:50 - 10:15 | Carl Nathan (Cornell U., New York, USA)
"Targeting Bacterial Defenses Against Oxidative Stress" |
| 10:15 - 10:25 | Discussion |
| 10:25 - 10:55 | Coffee Break |
| 10:55 - 11:20 | Mary Dinauer (Indiana U., Indianapolis, USA)
"Role of NADPH oxidase in host defense and inflammation" |
| 11:20 - 11:30 | Discussion |
| 11:30 - 11:55 | Anthony Segal (Centre Mol. Med, London, UK)
"A brand new model for how reactive oxygen kills microbes" |
| 11:55 - 12:05 | Discussion |
| 12:05 - 12:30 | Colette Dooley (U. California, San Diego, USA)
"Imaging redox changes in mammalian cells using green fluorescent protein sensors" |
| 12:30 | Lunch |
| 4:00 - 6:00 PM | Poster session |
| 6:00 | Dinner |
| 7:30 - 9:30 | Therapeutic approaches |
| Discussion Leader - Manisha Patel (National Jewish Medical & Research Center, Denver, USA) |
| 7:30 - 7:45 | Introduction to session: Manisha Patel |
| 7:45 - 8:10 | Simon Melov (Buck Institute, San Francisco, USA)
"Pharmacogenomic intervention of aging in mice" |
| 8:10 - 8:20 | Discussion |
| 8:20 - 8:45 | Jay Groves (Princeton U., USA)
Metalloporphyrins as Peroxynitrite Decomposition Catalysts: Mechanisms and Applications |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:20 | Daniela Salvemini
"SOD mimetics as effective therapeutic agents" |
| 9:20 - 9:30 | Discussion |
| WEDNESDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Diseases of heavy metal overload |
| Discussion Leader - Tracey Rouault (NIH, Bethesda, USA) |
| 9:00 - 9:15 | Introduction to session: Tracey Rouault |
| 9:15 - 9:40 | Jonathan Gitlin (Washington U., St. Louis, USA)
"Wilson Disease and hepatic copper toxicity" |
| 9:40 - 9:50 | Discussion |
| 9:50 - 10:15 | Jerry Kaplan (U. Utah, Salt Lake City, USA)
"Genetic analysis of iron mediated damage in yeast" |
| 10:15 - 10:25 | Discussion |
| 10:25 - 10:55 | Coffee Break |
| 10:55 - 11:20 | William Sly (St. Louis U., USA)
"Hereditary haemochromatosis and iron overload syndromes" |
| 11:20 - 11:30 | Discussion |
| 11:30 - 11:55 | John Burn (Institute of Human Genetics, Newcastle, UK)
"Neuroferritinopathy and iron-mediated damage" |
| 11:55 - 12:05 | Discussion |
| 12:05 - 12:30 | Elizabeth C. Theil (CHORI, Oakland, USA)
"Effects of transfusional iron on ferritin expression in sickle cell disease and beta-thalassemia" |
| 12:30 | Lunch |
| 4:00 - 6:00 PM | Poster Session |
| 6:00 | Dinner |
| 7:30 - 7:50 | Business meeting |
| 7:50 - 9:30 | Nrf2 and oxidative stress signaling |
| Discussion Leader - Kelvin Davies (U. Southern California, USA) |
| 7:50 - 8:05 | Introduction to session: Kelvin Davies |
| 8:05 - 8:40 | Paul Talalay (Johns Hopkins University, Baltimore, USA)
"Protection against oxidative stress by phase 2 gene induction" |
| 8:40 - 8:55 | Discussion |
| 8:55 - 9:20 | Jeff Johnson (U. Wisconsin, Madison, USA)
"The spectrum of the Nrf2 stress response" |
| 9:20 - 9:30 | Discussion |
| THURSDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Neurodegenerative Disorders and Oxidative damage |
| Discussion leader - Mark Gurney (DeCode Genetics, Iceland) |
| 9:00 - 9:15 | Introduction to session: Mark Gurney |
| 9:15 - 9:40 | Flint Beal (Cornell U., New York, USA)
"Markers of oxidative stress in neurodegeneration" |
| 9:40 - 9:50 | Discussion |
| 9:50 - 10:15 | Greg Cole (VA Medical Center/UCLA, Los Angeles, USA)
"Antioxidant Approaches for the Prevention or Treatment of Alzheimer's" |
| 10:15 - 10:25 | Discussion |
| 10:25 - 10:45 | Coffee Break |
| 10:45 - 11:10 | Dave Borchelt (Johns Hopkins University, Baltimore, USA)
"Copper-null SOD1 and Motor Neuron Disease" |
| 11:10 - 11:20 | Discussion |
| 11:20 - 11:45 | Li-Huei Tsai (Harvard U., Boston, USA)
"Dysregulation of Cdk5 and neurotoxicity" |
| 11:45 - 11:55 | Discussion |
| 11:55 12:200 | Ashley Bush (Mass General Hospital, Boston, USA)
"The metallobiology of neurodegeneration: Alzheimer's disease, ALS and cataracts" |
| 12:20 - 12:30 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 PM | Poster session |
| 6:00 | Dinner |
| 7:30 - 9:30 | Oxidative stress and cancer |
| Discussion Leader - Joan Valentine (U. California, Los Angeles, USA) |
| 7:30 - 7:45 | Introduction to session: Joan Valentine |
| 7:45 - 8:10 | Ting Ting Huang (U. California, San Francisco, USA)
"High frequency of tumor formation in SOD1 knock out mice" |
| 8:10 - 8:20 | Discussion |
| 8:20 - 8:45 | Lee Ann MacMillan-Crow (U. Alabama, Birmingham, USA)
"Peroxynitrite, MnSOD, and Pancreatic Cancer" |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:20 | Larry Oberley (U. Iowa, USA)
"Antioxidant Proteins and Cancer" |
| 9:20 - 9:30 | Discussion |
| FRIDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 | Departure |