| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Opening Keynote Address |
| Session Chair: Lynne Regan, Yale University |
| David Eisenberg, UCLA
"Protein Interactions: Normal and Pathological" |
| Welcoming Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Membrane Proteins |
| Session Chair: Olga Gursky, Boston University |
| Charles Deber, Toronto
"Role of Polar Residues in Membrane Domain Assembly and Stability" |
| Karin Akerfeldt, Haverford College
"Templated Alamethicin Channels" |
| James Bowie, UCLA
"Determinants of membrane protein structure" |
| Anne Robinson, U. Delaware
"Limitations to High Yield Expression of G-Protein Coupled Receptors in Yeast" |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Protein-Protein Interactions/New Methods |
| Session Chair: Thomas Baldwin, University of Arizona |
| Michael Fitzgerald, Duke
"SUPREX: A New H/D Exchange- and MALDI Mass Spectrometry-Based Method for Measuring the Thermodynamic Stability of Proteins in Solution" |
| Elizabeth Komives, U.C. San Diego
"Probing protein-protein interfaces and allosteric regulation by amide H/2H exchange" |
| Jim Hu, Texas A&M
"Homotypic oligomerization domains from genomes" |
| Virginia Cornish, Columbia
"Chemical Complementation: A Genetic Assay for Protein Evolution and Proteomics" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Protein Folding |
| Session Chair: C. Robert Matthews, U. Mass. Medical School |
| Carl Frieden, Wash U.
"Probing Protein Folding using 19F-NMR" |
| Bill Eaton, NIH
"Protein folding dynamics from single molecule fluorescence and laser temperature jump studies" |
| Peter Wright, Scripps
"Mapping protein folding landscapes by NMR" |
| Victor Muñoz, U. Maryland
"Protein Folding in the Absence of Free Energy Barriers: the One-State Folding Model" |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Poster presentations |
| Session Chair: Virginia Rath, U. of California, Berkeley, and Franz Schmid, Universitat Bayreuth |
| 7:30 pm - 9:30 pm | Folding and Design |
| Session Chair: David Goldenburg, University of Utah |
| Angela Gronenborn, NIH
"A Protein Contortionist: Folding and Folds of GB1" |
| David Giedroc, Texas A&M
Coordination Chemistry and Allosteric Switching in Bacterial Metal Sensor Proteins |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Proteins Therapeutics & Proteins in Disease I |
| Session Chair: Shalom Rackovsky, Mount Sinai School of Medicine |
| Jim Wells, Sunesis
"Drug Discovery at Signaling Interfaces" |
| Celia Schiffer, U. Mass. Medical School
"Substrate Recognition and Drug Resistance in HIV-1 Protease" |
| F. Ray Salemme, 3-Dimensional Pharmaceuticals
" Applications of high-throughput thermodynamic measurements for the investigation of protein stability and ligand binding" |
| Jean Baum, Rutgers
"NMR Insights into Human Folding Diseases" |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Poster presentations |
| Session Chairs: Virginia Rath, U. of California, Berkeley, and Franz Schmid, Universitat Bayreuth |
| 7:30 pm - 9:30 pm | Proteins in Disease II |
| Session Chair: Andrew Miranker, Yale University |
| Yuji Goto, Osaka U.
"Folding and amyloid fibril formation of beta2-microglobulin" |
| Jeff Kelly, Scripps
"Understanding the energetics of amyloidosis and manipulating the landscape with small molecules and trans-suppression to prevent disease"
|
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Protein Assemblies/Proteins in Action |
| Session Chair: Paul Curmi, U. of New South Wales |
| Enrique De La Cruz, Yale
"What the kinetics of myosin motors tell us about biological function" |
| Christopher Hill, Utah
"Opening the Gate to the Chamber of Death and Destruction" |
| Gary Ackers, Wash U.
"Mechanistic Roles of Intra-Dimer vs.Cross-Dimer Ligation in Human Hemoglobin" |
| Stan Burgess, U. of Leeds, UK
"The structure and power stroke of dynein: an unconventional linear motor" |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Lobster Dinner |
| 7:30 pm - 9:30 pm | Business Meeting
Closing Keynote Address |
| Session Chair: Rachel Klevit, U. of Washington, Seattle |
| Christopher Dobson, Cambridge University, UK
"Simplifying the Complexity of Protein Science" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |