Conference Program
 
Angiotensin

February 29 - March 5, 2004
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Chair:
Kenneth M. Baker

Vice Chair:
Martin Paul

Introduction and Overview

There will be a 2-Day Angiotensin Satellite Symposia before the meeting takes place (CLICK HERE FOR DETAILS). We encourage you to join your colleagues in this opportunity for additional scientific exchange and also to save on airfares (Saturday night stay). Meals will be on your own for this event. The symposia will focus on Central Angiotensin Pathways and the Role of Angiotensin in Regulation of the Immune System. Attendance at the Symposia is not mandatory for Angiotensin (GRC) conferees; however, session leaders and speakers for the symposia will need to attend the Angiotensin GRC for reimbursement of their expenses. Additional information will be added to this site at a later date, regarding registration, abstract submission dates for the poster sessions, and young investigator travel and registration awards. We will continue to send, at approximately bi-monthly intervals, updates regarding the meeting, to all conferees of the past three Angiotensin GRCs. If you have not been receiving these updates, but would like to be included on our e-mailing list, please contact the Chair for details.

Young Investigator Awards: 2004 Angiotensin Gordon Research Conference

We encourage young/new investigators (graduate and medical students; postdocs and fellows; those completing training in the last 5 years; and PhDs/MDs within the first five years of their faculty appointment, prior to December 31, 2003) to submit abstracts (deadline, December 31, 2003) of their proposed poster presentations. The abstracts should be submitted in standard format (title, authors, institution, text up to 400 words) to the Chair of the meeting; kbaker@medicine.tamu.edu. A separate abstract review committee, Chaired by Dr. Kathy Griendling, in coordination with the Session Leaders, will evaluate the abstracts and select several for dual poster and oral presentations. From this group of individuals, investigators will be chosen for The Angiotensin Gordon Research Conference FM Bumpus Young Investigator Award and MJ Peach Young Investigator Award. The awards will include a GRC issued certificate suitable for framing and coverage of registration, housing, and travel expenses.

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
4:00 pm - 6:00 pmReception
6:00 pmDinner
7:30 pm - 9:30 pmAT1 Receptor Structure and Function
Session Overview: Walter Thomas (Baker Medical Research Institute, Victoria, Australia)
Emanuel Escher (Universite de Sherbrooke, Sherbrooke, Quebec, Canada)
Structural Aspects of Angiotensin II Binding and Receptor Activation
Sadashiva Karnik (Cleveland Clinic, Cleveland, OH)
AT1 Receptor Activation - The Movie
Junichi Sadoshima (University of Medicine and Dentistry of New Jersey, Newark, NJ)
The Role of Heterotrimeric G protein and EGFR Coupling in Angiotensin II-induced Hypertrophy and Apoptosis in the Mouse Heart
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amPhoto
9:00 am - 12:30 pmMolecular Signaling of Angiotensin Receptors
Session Overview: Eric Clauser (Institut Cochin, Paris, France)
Kevin J. Catt (NICHD, NIH, Bethesda, MD)
Interactions and Signaling Between GPCRs and RTKs
Walter G. Thomas (Baker Medical Research Institute, Melbourne, Australia)
AT1 Signaling via EGFR Transactivation
Discussant: Satoru Eguchi (Temple University, Philadelphia, PA)
Vascular Tyrosine Kinase Network Activated by the AT1
10:30 amCoffee Break
Angiotensin Receptor Trafficking and Function of Signaling Complexes
Session Overview: Laszlo Hunyady (Semmelweis University, Budapest, Hungary)
Luis M. Luttrell (Duke University Medical Center, Durham, NC)
Role of Signaling Complexes in Angiotensin Growth Control
Stephen S. G. Ferguson (University of Western Ontario, London, Ontario, Canada)
Regulation of Angiotensin II Type 1A Receptor Endocytosis and Trafficking by Small G Proteins
Tamas Balla (NICHD, Bethesda, MD)
The Role of Inositol Lipids in the Formation of Signaling Complexes and in GPCR Trafficking
12:30 pmLunch
4:00 pm - 6:00 pmPoster Session and Reception
6:00 pmDinner
7:30 pm - 9:30 pmGenetics and Animal Models
Session Overview: Curt D. Sigmund (University of Iowa, Iowa City, IA)
Mansoor Husain (University of Toronto, Toronto, Ontario, Canada)
Tissue-specific Conditional Gene Expression: A Tool Enabling Unique Models of Cardiovascular Disease?
Scott Heximer (University of Toronto, Toronto, Ontario, Canada)
Please Mind the GAP -defining the role of RGS2 as a modulator of the renin-angiotensin system
Young Investigator Award Competition
Nicola J. Smith (University of Melbourne, Melbourne, AU)
Angiotensin II Receptor Transactivation of the EGF Receptor: Role of G Protein Coupling and Metalloprotease Activation in Cardiac Hypertrophy
Mizuo Mifune (Temple University School of Medicine, Philadelphia, PA)
EGF Receptor Transactivation-independent Rho/Rho Kinase Activation Mediates ANG II-induced JNK Activation and Migration in VSMCs
Yoshihiro Taniyama (Emory University School of Medicine, Atlanta, GA)
Reactive Oxygen Species- and PDK-1-dependent Downregulation of IRS-1 by Angiotensin II as a Cause of Insulin Resistance
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 amCardiovascular Genomics
Session Overview: TBA
Richard E. Pratt (Brigham and Women's Hospital, Boston, MA)
Physiological Genomics: High Throughput Strategies to Identify Genes Mediating RAS Effects
Mark Caulfield (Barts and the London School of Medicine and Dentistry, London, UK)
Genome Scans and Beyond in Complex Cardiovascular Traits
Young Investigator Award Competition
Hong D Xiao (Emory University School of Medicine, Atlanta, GA)
Mice with Cardiac Restricted Angiotensin Converting Enzyme Have Atrial Enlargement, Cardiac Arrhythmia and Sudden Death
Katia Savary (College de France, Paris, France)
Ontogeny and Possible Role of Angiotensin-converting Enzyme in Blood Islands Differentiation
Rajesh Kumar (Texas A&M University College of Medicine, Temple, TX)
Evidence of a Novel Intracrine Mechanism in Angiotensin II-induced Cardiac Hypertrophy
10:30 amCoffee Break
Posttranscriptional Regulation of AT Receptors
Session Overview: Georg Nickenig (University of Saarland, Hombourg, Germany)
Gary Brewer (University of Medicine and Dentistry of New Jersey, Piscataway, NJ)
Contributions of Posttranscriptional Controls to Gene Expression
Kathryn Sandberg (Georgetown University, Washington, DC)
Posttranscriptional Regulation of Angiotensin Receptors via Alternative Splicing
Thomas J. Thekkumkara (Texas Tech University, Amarillo, TX)
Posttranscriptional Regulation of AT1 Receptor: Is There a Role for mRNA Binding Proteins?
12:30 pmLunch
4:00 pm - 6:00 pmPoster Session and Reception
6:00 pmDinner
7:30 pm - 9:30 pmNovel Aspects of AT2 Receptor Function
Session Overview: Sadashiva Karnik (Lerner Research Institute, Cleveland, OH)
Clara Nahmias (Institut Cochin, Paris, France)
Novel AT2 Receptor Interacting Proteins Involved in Growth Inhibition
Anand K. Srivastava (J.C. Self Research Institute of Human Genetics, Greenwood, SC)
AT2 Receptor and Human Cognitive Function
Louis Gendron (Montreal Neurological Institute, Mc Gill University, Montreal, Quebec, Canada)
Novel Aspects of AT2 Receptor Signaling Involved in Neurite Outgrowth
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 amAng III and Ang IV - Novel Findings and Surprises
Session Overview: Frederick Mendelsohn (Howard Florey Institute, Melbourne, Australia)
Siew Yeen Chai (The University of Melbourne, Victoria, Australia)
Roles of AT4 Receptor / Insulin-Regulated Aminopeptidase in the CNS
Susanna R Keller (University of Virginia, Charlottesville, VA)
Physiological Functions of the Insulin-Regulated Aminopeptidase IRAP
Catherine Llorens-Cortes (College de France, Paris, France)
Central Actions of Ang III in Hypertension
Discussant: Genevieve Nguyen (College de France, Paris, France)
Mutation of the Renin Receptor is Associated with the Absence of ERK1/2 Activation in a Family with X-Linked Mental Retardation and Epilepsy
10:30 amCoffee Break
Angiotensin & Atherosclerosis
Session Overview: W. Robert Taylor (Emory University School of Medicine, Atlanta, GA)
Pascal Goldschmidt (Duke University School of Medicine, Durham, NC)
Atherosclerosis: Central Instead of Peripheral Hypothesis
Nobuyo N. Maeda (University of North Carolina, Chapel Hill, NC)
Blood Pressure Effects on Atherosclerosis in Mouse Models
Lisa L. Cassis (College of Pharmacy, University of Kentucky, Lexington, KY)
Mechanisms of Angiotensin II-Induced Atherosclerosis and Aneurysm Formation
Neal L. Weintraub (University of Iowa College of Medicine, Iowa City, IA)
Role of Oxidative Stress in Abdominal Aortic Aneurysm Formation Induced by Angiotensin II
12:30 pmLunch
4:00 pm - 6:00 pmReception
6:00 pmDinner
7:30 pm - 9:30 pmDevelopment and Plasticity of Renin-Expressing Cells
Session Overview: Ariel Gomez (University of Virginia, Charlottesville, VA)
Maria Luisa Sequeira Lopez (University of Virginia, Charlottesville, VA)
Studies on lineage and differentiation of renin-expressing cells
Victor Dzau (Harvard Medical School, Boston, MA)
Role of LXRalpha on Renin Transcription and Development
Kenneth Gross (Roswell Park Cancer Institute, Buffalo, NY)
Insights on renin from zebrafish
Josie Briggs (NIDDK, NIH, Bethesda, MD)
Macula Densa Control of Renin Relaese- Potential Pathways
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 amLocal Angiotensin Generation: Angiotensin II in Different Organs
Session Overview: Juerg Nussberger (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland)
Jan Danser (Erasmus Medical Center, Rotterdam, The Netherlands)
The Site of Angiotensin II Generation: Intra- or Extracellular?
Lucia Mazzolai (CHUV, Lausanne, Switzerland)
Angiotensin II and the Vascular System
Hans Imboden (Institute of Cell Biology, University of Bern, Bern, Switzerland)
Mapping of Angiotensin II and Angiotensin II Receptor Subtypes in the Central Nervous System: A Critical View
10:30 amCoffee Break
Impacts of Aldosterone on Cardiovascular Disease
Session Overview: Gail Adler (Brigham and Women's Hospital, Boston, MA)
David Pearce (University of California, San Francisco, CA)
Basic Physiology of Mineralocorticoid Receptor Action
Ricardo Rocha (Novartis Pharmaceutical Corp., East Hanover, New Jersey)
Pathophysiologic Mechanisms for Aldosterone-induced Hypertension and End-organ Damage
Gail Adler (Brigham and Women's Hospital, Boston, MA)
Animal Models of Aldosterone Induced Cardiovascular Injury
12:30 pmLunch
6:00 pmDinner
7:30 pm - 9:30 pmAwards Session
 
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: August 14, 2006