Conference Program
 
COMBINATORIAL CHEMISTRY

August 22-27, 2004
The Queen's College
Oxford, United Kingdom

Chair:
A Ganesan

Vice Chair:
Samuel W. Gerritz

Welcome to the 2004 Combinatorial Chemistry Gordon Research Conference! As chairman, my goal is a high-quality program that appeals to everyone and makes this a memorable meeting.

Based on the feedback from this year's questionnaires, I will be doing my best to ensure the following:

  1. A bigger poster session. Remember, this can only happen with your participation! Those who promise to present a poster will be given priority in registration and guaranteed a place.

  2. Keeping to the schedule. I would like the time limits to be strictly enforced. Most speakers include some introductory material that is unnecessary given the audience background and level of sophistication.

  3. Sufficient detail in industrial talks to keep the audience interested. If this is in doubt, I will get a brief outline from speakers beforehand. I plan to have some case studies of combinatorial and medicinal chemistry in action, with full disclosure of structure and activity. Similarly, if there are two talks from the same organisation, they must be on completely unrelated topics.

  4. Larger academic representation-some of you have complained it was too low this year. I am aiming for a high percentage of up and coming and less well-known speakers who you are unlikely to have seen at other conferences.

  5. Avoid speakers who have recently presented in this meeting. I have prepared an exhaustive database of all previous editions, plus all previous chairs and discussion leaders. I draw your attention to the indefatigable Sam Gerritz- 3 oral presentations, and a session chair every year since 2000.


If you have any comments or suggestions, please do not hesitate to contact me.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmDiversity-Oriented Synthesis
Discussion Leader: Jeffrey Aube (University of Kansas, Lawrence, USA)
7:30 pm - 8:20 pmAndrew Myers (Harvard University, Cambridge, USA)
Complex Natural Product Targets; Synthesis with a view towards Diversity
8:20 pm - 8:55 pmPrabhat Arya (National Research Council, Ottawa, Canada)
Natural Product-like Complex Polycyclics by Stereocontrolled Diversity Oriented Synthesis
8:55 pm - 9:30 pmJared Shaw (ICCB, Harvard University, Cambridge, USA)
Concise, Stereoselective Approaches to Libraries of Structurally Diverse Small Molecules
MONDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmNewer Approaches to Drug Discovery
Discussion Leader: Adrian Hobson (Abbott Bioresearch Center, USA)
9:00 am - 9:45 amMichael Pirrung (Duke University, Durham, USA)
Stalking the Billion-dollar Molecule
9:45 am - 10:30 amJeffrey Stafford (Syrrx, San Diego, USA)
Use of High-Throughput Nanovolume Crystallization in Structure-Based Drug Design
10:30 amCoffee Break
11:00 am - 11:45 amDaniel Erlanson (Sunesis, South San Francisco, USA)
Applications of Tethering to Drug Discovery
11:45 am - 12:30 pmBrent Stockwell (Columbia University, New York, USA)
Diagramming Disease Networks with Chemical and Biological Tools
12:45 pmGroup Photo and Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmCombinatorial Approaches to Catalysis
Discussion Leader: Fernando Albericio (University of Barcelona, Barcelona, Spain)
7:30 pm - 8:10 pmAlbrecht Berkessel (University of Koln, Koln, Germany)
Combinatorial Methods in Biomimetic Catalysis
8:10 pm - 8:50 pmHelma Wennemers (University of Basel, Basel, Switzerland)
Peptide Receptors - From Molecular Recognition to Catalytic Activity
8:50 pm - 9:30 pmJohannes de Vries (DSM, Geleen, Netherlands)
Two Combinatorial Approaches to Asymmetric Hydrogenation: The Monophos-family and Transition Metal Catalysts Attached to Enzymes
TUESDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmMulticomponent Reactions
Discussion Leader: Christine Brotherton-Pleiss (Roche, Palo Alto, USA)
9:00 am - 9:45 amJeffrey Aube (University of Kansas, Lawrence, USA)
Multicomponent Synthesis Inspired by Peptides and Alkaloids
9:45 am - 10:30 amAlexander Dömling (Morphochem, Munich, Germany)
High and Low Throughput MCR Chemistry
10:30 amCoffee Break
11:00 am - 11:45 amJ. Yadav (Indian Institute of Chemical Technology, Hyderabad, India)
Entry to New Class of NCEs via Metal Catalyzed Reactions
11:45 am - 12:30 pmChristopher Hulme (Amgen, Thousand Oaks, USA)
New Diversity Oriented Synthetic Methods & a Multi-Component Reaction based Case Study of a Hit-lead Transition Targeting a G-protein Coupled Receptor
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmLead Discovery and Optimization Case Studies - Part 1
Discussion Leader: John Lambert (Biota, Melbourne, Australia)
7:30 pm - 8:10 pmKonrad Bleicher (Roche, Basel, Switzerland)
Integrated Library Design and Parallel Synthesis Techniques for the Generation of Targeted Compound Libraries towards G-protein Coupled Receptors
8:10 pm - 8:50 pmShahzad Rahman (GlaxoSmithKline, Harlow, United Kingdom)
High Throughput Medicinal Chemistry: from Lead Generation to Optimisation
8:50 pm - 9:30 pmMasaki Yamada (Tanabe, Osaka, Japan)
Case studies: Design and Synthesis of Target-Based Libraries
WEDNESDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmSolid-phase Synthesis and Supported Reagents
Discussion Leader: Helma Wennemers (University of Basel, Basel, Switzerland)
9:00 am - 9:45 amFernando Albericio (University of Barcelona, Barcelona, Spain)
Solid-Phase Synthesis of Natural Products: Gaining Diversity by Different Steps in the Procedure
9:45 am - 10:30 amDennis Hall (University of Alberta, Edmonton, Canada)
Solid-phase Parallel Synthesis of Receptors and Sensors for Carbohydrates in Neutral Aqueous Environment
10:30 amCoffee Break
11:00 am - 11:45 amSteve Smith (Syngenta, Bracknell, United Kingdom)
Microencapsulated Palladium Catalysts: Application in Parallel Synthesis
11:45 am - 12:30 pmJan Scicinski (Nuada, Durham, USA)
An Analytical Platform for Screening Reactivity
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology
Discussion Leader: A. Ganesan (University of Southampton, Southampton, United Kingdom)
7:30 pm - 8:10 pmMaurizio Pellecchia (Burnham Institute, San Diego, USA)
Targeting Apoptosis by Chemical Biology: a Structure Based Approach
8:10 pm - 8:50 pmAndrew MacMillan (University of Alberta, Edmonton, Canada)
Biochemical Machinery of Combinatorial Protein Expression
8:50 pm - 9:30 pmGregory Weiss (University of California, Irvine, USA)
Combinatorial Libraries for Proteomics
9:30 pm - 10:00 pmBusiness Meeting
THURSDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmInstrumentation and Enabling Technologies
Discussion Leader: John Josey (Array Biopharma, Boulder, USA)
9:00 am - 9:45 amOliver Kappe (University of Graz, Graz, Austria)
Microwaves in Combinatorial and High-Throughput Synthesis. New Trends and Applications
9:45 - 10:30 amDavid Oare (Gilead, Foster City, USA)
Challenges and Choices for Supporting Array Synthesis on a Small Scale
10:30 amCoffee Break
11:00 am - 11:45 amPaul Hanson (University of Kansas, Lawrence, USA)
Ring-Opening Metathesis Polymerization: An Enabling Technology for Combinatorial Chemistry
11:45 am - 12:30 pmJohn Nuss (Exelixis, South San Francisco, USA)
Enhancing Lead Generation and Optimization via High-Throughput Synthesis Methods
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmLead Discovery and Optimization Case Studies - Part 2
Discussion Leader: Samuel Gerritz (Bristol-Myers-Squibb)
7:30 pm - 8:10 pmNeerja Bhatnagar (Aventis, Romainville, France)
From Active to Lead in Medicinal Chemistry: Contribution of Combinatorial Chemistry
8:10 pm - 8:50 pmJohn Lambert (Biota, Melbourne, Australia)
Design and Synthesis of Small Molecule Libraries to Address Respiratory Viral Disease
8:50 pm - 9:30 pmMarc-Andre Poupart (Boehringer Ingelheim, Laval, Canada)
Inhibitors of the Hepatitis C Virus NS5B Polymerase: Optimization of Benzimidazole-5-Carboxylic Acid Derivatives Using Parallel Synthesis
FRIDAY
7:45 am - 8:30 amBreakfast
9:00 amDepart

SUPPORTERS

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Last Updated: December 5, 2006