Conference Program
 
INTERFACIAL WATER IN CELL BIOLOGY

June 6-11, 2004
Mount Holyoke College
South Hadley, MA

Chairs:
Gerald H. Pollack & Chaim Frenkel


ABSTRACT

A significant fraction of cellular water consists of interfacial water, i.e., water that is confined by or in proximity to macromolecular and other kinds of surfaces. Proximity to interfaces appears to modify the structure and the physical properties of interfacial water, apparently toward higher degree of complexity but an understanding of the structure of interfacial water has, to date, escaped a complete and accepted description.

Because interfacial water may govern many or perhaps all aspects of cellular metabolism and because the physical properties of interfacial water are believed to be different from those of free water, it is of fundamental importance to understand how interfacial water mediates cellular processes. Examples are the role of interfacial water in macromolecular assembly and function, in allosteric regulation of proteins and enzymes, in energy metabolism or selectivity of cellular ion flux, in signal transmission, and in association of macromolecules with one another.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmCONTROVERSIAL HISTORY OF BIOLOGICAL WATER: VOICE OF THE PROTAGONISTS
Discussion Leader: Phillip Ball, Nature, London, UK
Walter Drost-Hansen, University of Miami, Coral Gables, FL
"From vicinal hydration of biopolymers to cell function"
Gilbert Ling, Damadian Foundation, Melville, NY
"The Polarized Multilayer (PM) theory of protoplasmic water in living cells"
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amPhoto
9:00 am - 12:30 pmPHYSICAL CHEMISTRY OF WATER AT BIOLOGICAL INTERFACES
Discussion Leader: Chaim Frenkel, Rutgers University
Elaine Zhu, Harvard University, Cambridge MA
"How water meets a hydrophobic surface"
Jacob Israelachvili, UC Santa Barbara
"Measurements of hydrophobic forces"
Martin Chaplin, South Bank University, London, UK
"Does water clustering determine biological structure?"
Gerald Pollack, Univ. of Washington, Seattle
"Solute behavior in the vicinity of hydrophilic surfaces"
12:30 pmLunch
6:00 pmDinner
7:30 pm - 9:30 pmINTERACTIONS BETWEEN MACROMOLECULES AND WATER
Discussion Leader: Martin Chaplin, South Bank University, London
Judith Herzfeld, Brandeis University, Waltham, Mass
"Crowding-induced order in cells"
Daryl Eggers, San Jose State University, San Jose, CA
"Influence of interfacial water on protein folding equilibria in crowded environments"
Teresa Head-Gordon, UC Berkeley, Berkeley, CA
"Hydration dynamics near a model protein surface: Implications for protein function and protein- protein assembly"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBEHAVIOR OF WATER IN THE PRESENCE OF SOLUTES AT EXTREMELY LOW CONCENTRATION
Discussion Leader: Pascale Mentre, Universite Pierre et Marie Curie, Paris, France
Jacques Benveniste, DigiBio, Clamart, France
"Role of water in the transmission of molecular signals"
Yolene Thomas, CNRS, Saint Cloud Cedex, France
"Activation of human neutrophils by electronically transmitted phorbol-myristate acetate"
Mae-wan Ho, Director, Institute of Science in Society
"The cell as a liquid crystal"
Shiimon Mizrahi, Technion Israel
"Water mediated cosolutes effects on gels swelling and osmotic pressure of polymers"
12:30 pmLunch
6:00 pmDinner
7:30 pm - 9:30 pmBASIC BIOPHYSICAL PROCESSES INVOLVING WATER
Discussion leader: Miklos Kellermayer, Univ of Pecs, Hungary
James Clegg, Univ of Cal., Davis, CA
Anhydrobiosis (life without water) reveals the essential functions of intracellular water
Vladimir Voeikov, Moscow State University, Russia
"Self-organizing nature of oxygen radical-dependent processes in aqueous systems"
Denys Wheatley, Univ. of Aberdeen, U. K.
"Metabolic control: diffusion, convection and encounter frequencies on cytoplasmic surfaces"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBEHAVIOR OF SOLUTES IN INTERFACIAL WATER
Discussion leader: John Sheehan, University of North Carolina
Norio Ise, Kyoto University, Japan
"When does like like like? -- Structure formation of macro-ions in solutions"
David Weitz, Harvard University, Cambridge MA
"Aqueous gels and networks: Mechano-properties and mechano-sensing"
Guenter Albrecht-Buehler, Northwestern Univ., Chicago, IL
"Water structuring centers of mammalian cell surfaces"
Ludwig Edelmann, Saarland University, Homburg/Saar, Germany
"Electron microscopic detection of potassium and water association at cellular proteins"
12:30 pmLunch
6:00 pmDinner
7:30 pm - 9:30 pmROLE OF INTERFACIAL WATER IN CYTOSKELETAL PROCESSES
Discussion leader: Carlton Hazlewood, President, PetroClean, L.L.C., and Research Consultants, International
Ivan Cameron, University of Texas, San Antonio, TX
"Water: Biology's forgotten molecule"
Dan Urry, Univ. of Minnesota, Twin Cities, MN
"The fundamental role of differentiated water structure in protein structure and function"
Frank Mayer, Univ. of Goettingen, Germany
"Interfacial Water: determinants for cell architecture and cell function"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmROLE OF INTERFACIAL WATER IN BIOLOGICAL PROCESSES
Discussion Leader: James Clegg, Univ. of California, Davis.
Virginia Shepherd, University of New South Wales, Sydney, Australia
"Plant cells through the looking glass: Alternative interpretations of cytoplasmic structure and electrophysiology"
Reuven Tirosh, Bar Ilan University, Ramat Gan, Israel
"Ballistic protons, water solitons, and bioenergetics"
Sasha Safronov, Ural State University, Ekaterineburg, Russia
"Hydration in synthetic polyelectrolyte gels. Electrochemical potential and enthalpy of swelling"
Fabio Bruni, University of Rome
"The glassy state of water in model and real systems: Is it biologically useful?"
12:30 pmLunch
6:00 pmDinner
7:30 pm - 9:30 pmROLE OF WATER IN BIOMATERIALS AND GELS
Discussion leader: Jacob Israelachvili, UC Santa Barbara
Erwin Vogler, Pennsylvania State University, University Park, PA
"Role of water in protein adsorption/assembly at interfaces"
Hans Griesser, University of South Australia, Adelaide, Australia
"Characterization of hydrated layers by colloid atomic force microscopy"
Allan Hoffman, University of Washington, Seattle, WA
"The role of water in PEGylated 'non-fouling' surfaces"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: August 14, 2006