Conference Program
 
Isotopes In Biological & Chemical Sciences

February 15-20, 2004
Crowne Plaza
Ventura, CA

Chair:
David N. Silverman

Vice Chair:
Charles L. Perrin

This multi-disciplinary conference explores the frontiers of isotope research in chemistry and biology, with links to physics and other areas of the natural and applied sciences. The goal is the exchange of novel concepts and ideas between these scientific areas in order to stimulate future research. The sessions and talks are arranged in such a way that the participants from different research areas, including undergraduate and graduate students, are introduced to the strongly developing field of the use of isotopes, starting from physical chemistry to biochemistry, with a special emphasis on reaction mechanisms, hydrogen transfer, and bonding. Special efforts are made to promote the discussion between scientists of different research areas. In addition to oral presentations, this Conference has always had highly stimulating poster sessions with the majority of attendees presenting either a talk or a poster. Interested scientists including graduate students will be encouraged to submit abstracts, and some poster presenters will be invited to give an oral presentation. In addition, this is the 50th Anniversary of this Conference. Participants at the first Gordon Conference on Isotopes and other past chairs will discuss the origins of this conference and assess the development of the topic from their perspectives.

Attendees who would like to present a poster should send an abstract containing title, authors, and affiliations Dr. Charles L. Perrin at cperrin@ucsd.edu

Corporate and Academic Supporters
University of Florida, Department of Pharmacology
Thomas H. Maren Foundation
GlaxoSmithKline
University of Florida, Division of Sponsored Research
Sigma-Aldrich
Merck Research Laboratories
Wyeth Research
Spectra Gases
Individual Supporters
Anonymous Donors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
5:00 pmReception (Poster Room)
6:00 pmDinner
7:30 pm - 7:40 pmOpening of the Conference
Nancy Ryan Gray, Director, Gordon Research Conferences
Opening Comments
Jacob Bigeleisen (Chair, First GRC on Isotopes, 1954)
Introduction to the 50th Anniversary Session
7:40 pm - 9:30 pmIsotopic Information in Atmospheric Chemistry
Discussion Leader: Max Wolfsberg (University of California, Irvine)
7:40 pm - 8:15 pmF. Sherwood Rowland (University of California, Irvine)
"Some Isotopic Applications in Atmospheric Chemistry"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 9:00 pmJeffrey Severinghaus (Scripps Institution of Oceanography)
"History of climate from gas isotope fractionation by thermal diffusion in air bubbles trapped in glacial ice"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmKristie Boering (University of California, Berkeley)
"Unusual Kinetic Isotope Effects, Greenhouse Gases, and Climate: From the Molecular to the Global State"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmElucidation of Organic Reaction Mechanisms by Kinetic Isotope Effects
Discussion Leader: Jerry Kresge (University of Toronto)
9:00 am - 9:35 amJohn Richard (SUNY at Buffalo)
"Primary Kinetic Isotope Effects and Intrinsic Reaction Barriers for Proton Transfer at Carbon"
9:35 am - 9:50 amDiscussion
9:50 am - 10:25 amGroup Photo and Coffee Break
10:25 am - 11:00 amDan Singleton (Texas A&M)
"Dynamic Selectivity and Isotope Effects in Ordinary Organic Reactions in Solution"
11:00 am - 11:15 amDiscussion
11:15 am - 11:50 amVernon Parker (Utah State University)
"Consecutive Transition States on the Reaction Coordinates for C-H Proton and Hydride Transfer Reactions. Apparent and Real Deuterium Kinetic Isotope Effects"
11:50 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmJohn Thoburn (Randolph-Macon College)
"Quantum Dynamics of [1,7] Hydrogen Shift in 1,3,5-Heptatrienes: Implications for Kinetic Isotope Effects and Swain-Schaad Exponents"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHydrogen-Bonding: Advances in Structure and Dynamics
Discussion Leader: Charles L. Perrin (University of California San Diego)
7:30 pm - 8:05 pmDan O'Leary (Pomona College)
"Deuterium and Tritium NMR Equilibrium Isotope Effects Involving OH/OH and CH/N Hydrogen Bonds: Applications in Conformational and Configurational Analysis"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmHans Heinrich Limbach (Free University Berlin)
"Hydrogen Bond Isotope Effects studied by NMR"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSosale Chandrasekhar (Indian Institute of Science)
"Isotope Effects on Hydrogen Bonding: Implications for the Theory of Primary Kinetic Isotope Effects"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProbing Inorganic Reactions with Kinetic Isotope Effects
Discussion Leader: James Mayer (University of Washington)
9:00 am - 9:35 amMichael Heinekey (University of Washington)
"Structural Isotope Effects in Transition Metal Dihydrogen Complexes"
9:35 am - 9:50 amDiscussion
9:50 am - 10:05 amKlaus Theopold (University of Delaware)
"Hydrogen Atom Tunneling in C-H Activation by Metal Oxo Complexes"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:20 amWilliam D. Jones (University of Rochester)
"Isotope Effects in C-H Bond Activation Reactions by Transition Metals"
11:20 am - 11:35 am Discussion
11:35 am - 12:10 pm David M. Kramer (Washington State University)
"Proton-coupled electron transfer during hydroquinone oxidation at cytochrome bc1 and b6f complexes and in biomimetic systems"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThermodynamics of Isotope Effects in Solutions, including Polymer Solutions
Discussion Leader: Alexander Van Hook (University of Tennessee)
7:30 pm - 8:05 pmLuis Rebelo (New University of Lisbon)
"Esoteric isotope effects on the thermodynamics of 'simple' and 'not-so-simple' systems. A view from the shore."
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmJohannes Messinger (Max Planck Institute for Bioinorganic Chemistry)
"Analyzing the Mechanism of Photosynthetic Water Oxidation Using Time-Resolved Isotope Ratio Mass Spectrometry"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:30 pmJacob Bigeleisen (SUNY Stony Brook)
Jack Shiner (Indiana University)
Max Wolfsberg (University of California Irvine)
"Origins of the Gordon Conference on Isotopes" Panel Discussion
9:30 pm - Discussion and Refreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Enzyme Catalyzed Reactions
Discussion Leader: Piotr Paneth (Technical University of Lodz)
9:00 am - 9:35 amJustine Roth (Johns Hopkins)
"Oxygen-18 kinetic isotope effects on O2 activation reactions"
9:35 am - 9:50 amDiscussion
9:50 am - 10:05 amPatrick Frantom (Texas A&M University)
"Uncoupled Mutant Forms of Tyrosine Hydroxylase Unmask Deuterium Secondary and Solvent Isotope Effects"
10:05 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:20 amW. Wallace Cleland (University of Wisconsin)
"The Use of Isotope Effects to Determine Enzyme Mechanisms"
11:20 am - 10:35 am Discussion
11:35 am - 12:10 pm Wilfred van der Donk (University of Illinois)
"An unusual isotope effect on substrate inhibition in lipoxygenase"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTheoretical Approaches to the Interpretation of Isotope Effects
Discussion Leader: Zorka Smedarchina (NRC of Canada)
7:30 pm - 8:05 pmDon Truhlar (University of Minnesota)
"Variational transition state theory with multidimensional tunneling calculations for the calculation of kinetic isotope effects"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmWillem Siebrand (NRC of Canada)
"Enzymatic CH-bond cleavage: An isotopic perspective"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSonja Braun-Sand (University of Southern California)
"Validation of Simplified Models for Studies of Proton Translocations in Biological Systems"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHydrogen Tunneling: Linking Catalysis to Motion and Dynamics
Discussion Leader: Judith Klinman (University of California Berkeley)
9:00 am - 9:35 amSteve Schwartz (A. Einstein College of Medicine)
"Kinetic Isotope Effects in Coupled Electron Proton Transfer Reactions - what can we learn from models?"
9:35 am - 9:50 amDiscussion
9:50 am - 10:05 amAmnon Kohen (University of Iowa)
"Environmentally Coupled Tunneling in Enzymatic Hydride Transfer Reactions"
10:05 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:20 amRichard G. Finke (Colorado State University)
"A New, Coenzyme B12 Experimental Test of the Enzyme-Enhanced H-Tunneling Hypothesis"
11:20 am - 11:35 am Discussion
11:35 am - 12:10 pmSharon Hammes-Schiffer (Pennsylvania State University)
"Hydrogen Tunneling and Protein Motion in Enzyme Reactions"
12:10 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Protein Dynamics using Isotopic Probes
Discussion Leader: Al Mildvan (Johns Hopkins University)
7:30 pm - 8:05 pmDorothee Kern (Brandeis University)
"Enzymes in Action - Protein Dynamics During Catalysis and Signaling"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmRichard Armstrong (Vanderbilt)
"Evaluation of Enzyme Structure and Dynamics with Amide H/D Exchange Mass Spectrometry"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmWilliam Bachovchin (Tufts University)
"Active Site H-Bonds, Histidine Ring Dynamics and the Catalytic Mechanism of Serine Proteases"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: August 14, 2006