Conference Program
 
METALS IN BIOLOGY

January 18-23, 2004
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Chair:
Alison Butler

Vice Chair:
John H. Dawson

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmSEARCHING SEQUENCES FOR POTENTIAL METAL-BINDING SITES
Discussion Leader: Richard H. Holm (Harvard University)
7:30 pm - 8:30 pmJeremy M. Berg (National Institute of General Medical Sciences)
“Searching Genomes for and with Zinc-Binding Domains”
8:45 pm - Chair's Reception and Poster Session (Poster Presenters A-H)
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMETALLONEUROCHEMISTRY
Discussion Leader: Carol Fierke (University of Michigan)
9:00 am - 9:30 amStephen J. Lippard (Massachusetts Institute of Technology)
"Metalloneurochemistry: Fluorescent Probes for Zinc, Mercury, and Nitric Oxide"
9:45 am - 10:15 amChris Frederickson (Neurobiotex)
"Synaptic and Somatic Release of Zinc"
10:30 amCoffee Break
11:00 am - 11:30 amAlan Kay (University of Iowa)
"Is Synaptic Zinc Really Released?"
11:45 am - 12:15 pmThomas V. O'Halloran (Northwestern University)
"Inorganic Physiology of Zinc: Insights from Chemical and Biological Metal Sensors"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Poster Presenters A-H)
6:00 pmDinner
7:30 pm - 9:30 pmIRON TRANSPORT AND STORAGE IN METABOLISM AND DISEASE
Discussion Leader: Seth Cohen (UC San Diego)
7:30 pm - 8:00 pmElizabeth C. Theil (Children's Hospital of Oakland Research Institute)
"New Twists in Managing Iron and Oxygen - The Ferritin Nanoreactor"
8:15 pm - 8:45 pmKenneth N. Raymond (UC Berkeley)
"Microbial Iron Transport and Human Disease"
9:00 pm - Poster Session (Poster Presenters A-H)
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPROTEIN FOLDING, MISFOLDING AND DISEASE
Discussion Leader: Jay Winkler (California Institute of Technology)
9:00 am - 9:30 amAshley I. Bush (Harvard Medical School)
"The Metallobiology of Alzheimer's Disease"
9:45 am - 10:15 amKara L. Bren (University of Rochester) (2004 SALTMAN LECTURER)
"Cytochrome c Folding and Dynamics Probed by NMR"
10:30 amCoffee Break
Discussion Leader: Kevin Plaxco (UC Santa Barbara)
11:00 am - 11:30 amTobin R. Sosnick (University of Chicago)
"Discerning the Structure and Energy of Multiple Transition States in Protein Folding Using Designed Metal Binding Sites and Graphics/symbols/greek/psi.gif-Analysis"
11:45 am - 12:15 pmHarry B. Gray (California Institute of Technology)
"Mapping Metalloprotein Folding Landscapes"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Poster Presenters I-Z)
6:00 pmDinner
7:30 pm - 9:30 pmMETALS, PROTEINS, NUCLEIC ACIDS AND SENSORS
Discussion Leader: Victoria DeRose (Texas A&M University)
7:30 pm - 8:00 pmYi Lu (University of Illinois)
"New Metallo-DNAzymes: From Fundamental Insights into Metal-binding Sites in Nucleic Acids to Practical Application as Metal Ion Sensors"
8:15 pm - 8:45 pmRobert A. Scott (University of Georgia)
"The Zinc Ribbon Motif in Transcription Initiation"
9:00 pm - 9:20 pmChristoph Fahrni (Georgia Institute of Technology)
SHORT TALK: “Rational Design of Fluorescent Sensors for the Biological Chemistry of Copper
9:30 pm - Poster Session (Poster Presenters I-Z)
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmENVIRONMENTAL BIOINORGANIC CHEMISTRY
Discussion Leader: Edward I. Stiefel (Princeton University)
9:00 am - 9:30 amDianne K. Newman (California Institute of Technology)
"How Bacteria Respire Minerals"
9:45 am - 10:15 amBradley M. Tebo (Scripps Institution of Oceanography, UC San Diego)
"Unraveling Bacterial Mn(II) Oxidation Step by Step: Molecular Mechanisms, Reaction Intermediates and Products"
10:30 amCoffee Break
11:00 am - 11:30 amFrancois M. M. Morel (Princeton University)
"Unusual Use of Trace Metals to Sustain the Productivity of the Oceans"
11:45 am - 12:15 pmWalter Schaffner (University of Zurich)
"Heavy Metal Stress Response from Insects to Mammals"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Poster Presenters I-Z)
6:00 pmDinner
7:30 pm - 9:30 pmNITROGENASE MIMETIC CHEMISTRY
Discussion Leader: Julia A. Kovacs (University of Washington)
7:30 pm - 8:00 pmRichard R. Schrock (Massachusetts Institute of Technology)
"Catalytic Reduction of Dinitrogen at a Single Molybdenum Center"
8:15 pm - 8:35 pmSonny C. Lee (Harvard University)
SHORT TALK "Weak-Field Iron and Nitrogen Anions: Synthetic Cluster Chemistry and the Nitrogenase Problem"
8:45 pm - 9:05 pmJonas C. Peters (California Institute of Technology)
SHORT TALK "Dinitrogen Chemistry from Trigonally Coordinated Iron Platforms"
9:15 pm - Poster Session (Poster Presenters I-Z)
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMECHANISTIC CHEMISTRY OF FeHEME ENZYMES
Discussion Leader: David M. Dooley (Montana State University)
9:00 am - 9:30 amJohn H. Dawson (University of South Carolina)
"Oxygen Activation by Cytochrome P450: Mechanistic Evidence from Studies with P450-CAM as a Model System"
9:45 am - 10:15 amIsao Morishima (Kyoto University)
"Molecular Mechanism of P450cam Catalyzed Oxygenation Reaction Regulated by the Association with Putidaredoxin"
10:30 amCoffee Break
11:00 am - 11:20 pmAngela Wilks (University of Maryland)
SHORT TALK "Heme Transfer to Heme Oxygenase: Characterization of a Bacterial Heme Chaperone and Its Role in Pathogenesis"
11:30 am - 11:50 pmEric Hegg (University of Utah)
SHORT TALK "Heme A Biosynthesis: Unraveling the Unusual Oxidative Mechanism"
12:00 pm - 12:20 pmC.S. Raman (University of Texas Medical School)
SHORT TALK: "Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session Graduate Research Seminar Poster Presentations
5:15 pm - 6:00 pmBusiness Meeting
6:00 pmBanquet (Joint with the Graduate Research Seminar Conference)
7:30 pm - 9:30 pmJOINT SESSION WITH THE GRADUATE RESEARCH SEMINAR
Discussion Leader: Harry B. Gray (California Institute of Technology)
Introductory Remarks: Alison Butler (UC Santa Barbara)
7:30 pm - 8:30 pmGeorge L. McLendon (Princeton University)
"Cytochrome c and the Suicide Hot Line"
9:00 pm - Poster Session of the Graduate Research Seminar Posters
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: May 4, 2006