Conference Program
 
NATURAL PRODUCTS

July 25-30, 2004
Tilton School
Tilton, NH

Chair:
Jon D. Rainier

Vice Chair:
Joseph D. Armstrong

53rd NATURAL PRODUCTS GORDON RESEARCH CONFERENCE

In its present form, the field of Natural Products Chemistry not only encompasses the more traditional disciplines of isolation, total synthesis, and methods development, but it also has expanded into medicinal chemistry, chemical biology, and molecular biology. It was with the diversity of the field in mind that the 53rd Natural Products Gordon Research Conference was organized. As we hope you can see from the schedule, individuals who are among the leaders in their respective disciplines have agreed to present lectures at this year's conference. The topics of these lectures will literally span the rather broad scope of this discipline.

In addition to the invited lectures, the normal afternoon and evening poster sessions will be held. We encourage you to consider submitting a poster for these sessions: The poster sessions are important to the success of the meeting and are a fantastic forum to receive feedback on your latest results. In addition to all of this, a few of the posters will be chosen to give short talks at the meeting. The Vice-Chair for this year's meeting, Joe Armstrong, will be in charge of both the poster sessions and choosing the speakers from the posters. Please take the time to forward your posters to Joe at joe_armstrong@merck.com.

As has been the case since this conference moved to Tilton, we anticipate that you'll find the Tilton School an almost ideal location for this meeting. We very much look forward to seeing you in Tilton!

Jon Rainier (University of Utah), Chair
Joe Armstrong (Merck & Co.), Vice Chair

FINANCIAL SUPPORT FROM THE FOLLOWING INDIVIDUALS
AND ORGANIZATIONS IS GRATEFULLY ACKNOWLEDGED

Abbott Laboratories
Albany Molecular Research Inc.
Allergan
Amgen, Inc.
Arena Pharmaceuticals, Inc.
Aventis Pharmaceuticals Inc.
Boehringer Ingelheim Corporation
Bristol-Myers Squibb Company
Chiron Corporation
Conjuchem
Eisai Research Institute
Eli Lilly and Company
Exelixis, Inc.
Genentech, Inc.
Gilead Sciences
GlaxoSmithKline
Ross M. Johnson
Merck & Co., Inc.
Neurogen Corporation
Ortho-McNeil Pharmaceutical, Inc.
Pfizer, Inc.
Pfizer/GRC Chemistry Student Fellowships
Roche Palo Alto LLC
Schering Plough Research Institute
Wyeth Pharmaceuticals

SUNDAY
2:00 pm - 9:00 pmArrival and check-in
6:00 pm Dinner
7:30 pm - 9:30 pmEVENING SESSION
7:30 pm - 7:40 pmJon D. Rainier (U. of Utah)
Chair's Opening Remarks
George A. O'Doherty (West Virginia University)
7:40 pm - 8:25 pmMichael P. Doyle (U. of Maryland)
"Advantages of Chiral Dirhodium(II) Carboxamidates for Asymmetric Synthesis"
8:25 pm - 8:45 pmJanis Louie (U. of Utah)
"Nickel-Catalyzed Cycloaddition Reactions"
8:45 pm Barry Trost (Stanford U.)
"The Impact of New Synthetic Methodology on Strategies to Bioactive Natural Products"
9:30 pm Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amPHOTO SESSION
9:00 am - 12:30 pmMORNING SESSION
Discussion Leader: Carrie A. Wager (Pfizer Inc.)
9:00 am - 9:40 amSamit K. Bhattacharya (Pfizer Inc.)
"Discovery of CP-724714, a Potent and Selective ErbB2 Receptor Tyrosine Kinase Inhibitor"
9:40 am - 10:00 amThomas E. Smith (Williams College)
"Asymmetric Synthesis of Pyran-Based Natural Products"
10:00 am - 10:30 amCoffee Break
Discussion Leader: Timothy F. Jamison (Massachusetts Institute of Technology)
10:30 am - 11:15 amJames Guy Breitenbucher (R. W. Johnson PRI)
"The Value of Combinatorial SAR in the Development of a Novel Series of CCK-1 Receptor Antagonists"
11:15 am - 11:45 amDavid Myles (Kosan Biosciences)
"Polyketide Synthase Gene Engineering and Chemical Synthesis to Access New Drug Molecules"
11:45 am - 12:30 pmPhil Crews (U.C. Santa Cruz)
"New Twists in the Discovery of Important Biomolecules from Sponges and Their Microbial Associates"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pm Dinner
7:30 pm - 9:30 pmEVENING SESSION
Discussion Leader: Richard E. Taylor (University of Notre Dame)
7:30 pm - 8:15 pmMichael T. Crimmins (U. of North Carolina)
"Enantioselective Approaches to Acetogenin Natural Products"
8:15 pm - 8:45 pmPatrick G. Harran (University of Texas Southwestern Medical Center)
"Synthetic Means to Reach Natural Ends"
8:45 pm Dale L. Boger (Scripps Research Institute)
"Yatakemycin: Synthetic and Mechanistic Studies"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMORNING SESSION
Discussion Leader: Katherine L. Lee (Wyeth Research)
9:00 am - 9:45 amStuart J. Mickel (Novartis Pharma AG)
"Large Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide: Scale-up Problems and Initial Solutions"
9:45 am - 10:15 amCynthia K. McClure (Montana State U.)
"Adventures in Synthetic Photochemistry"
10:15 amCoffee Break
Discussion Leader: Nancy I. Totah (Syracuse University)
10:45 am - 11:15 amMiwako Mori (Hokkaido U.)
"Total Synthesis of Some Natural Alkaloids using Organometallic Complexes"
11:15 am - 11:45 amMakoto Sasaki (Tohuku U.)
"Total Synthesis of Marine Polycyclic Ethers by B-Alkyl Suzuki-Miyaura Coupling"
11:45 am - 12:30 pmSteve Hanessian (U. of Montreal)
"Incentives for New Methodology Through Natural Product Synthesis"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pm Dinner
7:30 pm - 9:30 pmEVENING SESSION
Discussion Leader: Dee Ann Casteel (Bucknell University)
7:30 pm - 8:15 pmPeter Wuts (Pfizer Inc.)
"A Chemobiological Synthesis of Eplerenone"
8:15 pm - 8:45 pmBradley S. Moore (U. of Arizona)
"Structure and Mechanism of Type III Polyketide Synthases: The Possibility of Enzymatic Protecting Group Chemistry"
8:45 pm Carolyn R. Bertozzi (U.C. Berkeley)
"The Chemistry and Biology of Mycobacterial Virulence Factors"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMORNING SESSION
Discussion Leader: Rogelio P. Frutos (Boehringer Ingelheim Pharmaceuticals, Inc.)
9:00 am - 9:20 amWilliam R. Leonard (Merck & Co.)
"CANCIDAS: The Making of a Drug"
9:20 am - 9:40 amMartin J. Lear (Tohoku University)
"Reliable Routes to Fully-Fledged, Bicyclic Nine-Membered Epoxyenediynes for DNA and EPR Studies"
9:40 am - 10:00 amThomas R. Pettus (University of California, Santa Barbara)
"The First Enantioselective Synthesis of (+)-Rishirilide B and Approach Towards (+)-Rishirilide A"
10:00 amCoffee Break
Discussion Leader: Richard P. Hsung (University of Minnesota)
10:30 am - 11:15 amMichael L. Curtin (Abbott Laboratories)
"Novel Hydroxamate and Non-hydroxamate Histone Deacetylase Inhibitors"
11:15 am - 11:45 amCarol Taylor (Massey U.)
"Peptides Containing Hydroxyprolines: Synthesis, Conformation and Function"
11:45 am - 12:30 pmWilliam R. Roush (U. of Michigan)
"Recent Studies on the Total Synthesis of Natural Products: Strategy, Tactics, and New Synthetic Methodology"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pm Dinner
7:30 pm - 9:30 pmEVENING SESSION
Discussion Leader: Frances Rose M. Blase (Haverford College)
7:30 pm - 8:15 pmIan Paterson (Cambridge U.)
"Synthesis of Polyketides of Marine Origin as Promising Anti-Cancer Agents"
8:15 pm - 8:45 pmJef K. De Brabander (University of Texas Southwestern Medical Center)
"Synthesis and Functional Studies of Natural Products"
8:45 pm Amos B. Smith, III (U. of Pennsylvania)
"Total Synthesis of Architecturally Complex Natural and Unnatural Products: Challenges, Excitement and Frustrations"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMORNING SESSION
Discussion Leader: William A. Donaldson (Marquette University)
9:00 am - 9:20 amKarl Scheidt (Northwestern University)
"Thiazolium-Catalyzed Reactions of Acylsilanes: A New Strategy for Acyl Anion Additions"
9:20 am - 9:40 amKazunori Koide (University of Pittsburgh)
"Chemistry and Biology of the Antitumor Antibiotic FR901464"
9:40 am - 10:00 am Mark C. McMills (Ohio U.)
"Carbene and Nitrene Reactions of Natural Products"
10:00 amCoffee Break
Discussion Leader: Robert E. Maleczka (Michigan State University)
10:30 am - 11:15 amMichael Williams (Merck Research Laboratories)
"Synthesis of a Potent Hepatitis C Virus (HCV) Polymerase Inhibitor"
11:15 am - 11:45 amIrina P. Beletskaya (Moscow State U.)
"Pd- and Ni-catalyzed substitution and addition reactions leading to carbon-carbon and carbon-heteroatom bond formation"
11:45 am - 12:30 pmLeo Paquette (Ohio State U.)
"Lessons Learned from Synthetic Approaches to Structurally Unusual Terpenes"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
2:00 pm - 4:00 pmAcademic vs. Industrial Softball Game
6:00 pm Dinner
7:30 pm - 9:30 pmEVENING SESSION
Discussion Leader: David E. Uehling (GlaxoSmithKline)
7:30 pm - 8:15 pmJun'ichi Kobayashi (Hokkaido U.)
"Bioactive Products from Marine and Other Sources"
8:15 pm Stuart Schreiber (Harvard U.)
"Parallel Roles for the Academic and Industrial Communities in Drug Discovery"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 am Departure
Last Updated: August 14, 2006