Conference Program
 
CARDIAC ARRHYTHMIA MECHANISMS

February 20-25, 2005
Santa Ynez Valley Marriott
Buellton, CA

Chair:
Jose Jalife

Vice Chair:
Igor R. Efimov

Cardiac arrhythmias are major causes of morbidity and mortality throughout the world. Yet, despite many years of research, understanding the precise mechanisms of the most complex arrhythmias, including atrial and ventricular fibrillation remains elusive. New approaches to identifying ways to diagnose, treat, and prevent cardiac arrhythmias will require the use of highly sophisticated tools that, in many cases, would consist of combinations of multiple technologies including, genetics, molecular and structural biology, directed differentiation of cloned embryonic stem cells, immunochemistry, patch-clamping, optical and high density electrode mapping of electrical wave propagation, and computer modeling. The meeting will focus on both basic science and the clinically relevant key scientific topics. It provides an ideal setting for interdisciplinary interactions between physiologists, molecular biologists, biophysicists, biomedical engineers, clinicians as required for addressing the complex phenomena of cardiac arrhythmias and sudden death. The plan is to invite the top experts in their respective fields to a forum where they can present and together discuss the most exciting new contributions to the understanding of the mechanisms of cardiac rhythm disturbances.

Program Committee
Jose Jalife (Chair), Igor Efimov (Co-Chair), Glenn Fishman, Andre Kleber, Gideon Koren, Barry London, Michael Rosen, Yoram Rudy, Guy Salama.

Poster Sessions
Gordon Research Conferences are all about inclusiveness and the use of posters will permit many of the conferees, including graduate students and postdocs, to actively participate in the meeting. The Vice-Chair of the Conference, Dr. Igor Efimov, will be responsible for the poster sessions. Efforts will be made to ensure that poster sessions are organized so that the overall program of the Conference retains a coherent nature.

"The GRC on Cardiac Arrhythmia Mechanisms is responsive to the needs of a diverse community and reaches out to include people of diverse ethnic, racial, economic, and gender groups."


Graphics/Programs/2005/cardiac3.jpg

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 8:30 pmSudden Cardiac Death: Where are we and where are we going in the next 20 years?
7:30 pm - 7:45 pmConference Introduction: José Jalife (SUNY Upstate Medical University)
7:45 pm - 8:30 pmDouglas P. Zipes (Indiana University)
Sudden Cardiac Death: Where are we and where are we going in the next 20 years?
8:30 pm - 9:30 pmPanel Discussion
Major challenges and opportunities related to the mechanisms of arrhythmias and sudden cardiac death
Discussion Leader: Douglas P. Zipes (Indiana University)
David Lathrop (National Institutes of Health)
Roger Karam (Procter & Gamble Pharmaceuticals)
Walter Olson (Medtronic, Inc)
Mark Kroll (St. Jude, Inc)
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amPhoto
9:00 am - 12:30 pmSodium Channel Dysfunction as a Trigger of Arrhythmias
Discussion Leader: Augustus Grant (Duke University)
9:00 am - 10:00 amRobert Kass (Columbia University)
Mutations in cardiac sodium channels: clinical implications
10:00 amCoffee Break
10:30 am - 11:30 amJonathan Makielski (University of Wisconsin - Madison)
Trafficking defects and rescue of Na channel arrhythmia mutations
11:30 am - 12:30 pmYoram Rudy (Washington University)
Modeling the electrophysiological consequences of sodium channel dysfunction
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPotassium Channels and Reentrant Mechanisms
Discussion Leader: Gideon Koren (Harvard University)
7:30 pm - 8:10 pmJeanne Nerbonne (Washington University)
Voltage-regulated channels and arrhythmias
8:10 pm - 8:50 pmLouis J. Ptacek (University of Utah)
Genetics of Kir2.x channels and arrhythmias
8:50 pm - 9:30 pmAnatoli Lopatin (University of Michigan)
Inward rectifying channels in mouse models of fibrillation
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Calcium Cycling and Arrhythmias
Discussion Leader: Donald Bers (Loyola University)
9:00 am - 10:00 amDavid Yue (Johns Hopkins)
Calmodulin regulation of L-type (CaV1) Ca2+ channels: impact on ventricular excitability and beyond
10:00 amCoffee Break
10:30 am - 11:30 amSteven Pogwizd (University of Illinois)
Na/Ca exchange, contractile dysfunction and arrhythmogenesis
11:30 am - 12:30 pmGuy Salama (University of Pittsburgh)
Intracellular Calcium as a trigger of Arrhythmias
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell-to-Cell Communication in Health and in Disease
Discussion Leader: Denis Escande(Universite De Nantes, France)
7:30 pm - 8:10 pmMario Delmar (SUNY Syracuse)
Regulation of connexin function by their binding partners
8:10 pm - 8:50 pmJeffrey Saffitz (Washington University)
Gap junctions and cell junctions in health and disease
8:50 pm - 9:30 pmStephan Rohr (University of Berne)
Coupling of cardiac myocytes by fibroblasts of cardiac origin
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReentry and Ventricular Fibrillation
Discussion Leader: Igor Efimov (Washington University)
9:00 am - 10:00 amPeter Backx (University of Toronto)
Regulation of K+ channels and heterogeneity of repolarization in the heart
10:00 amCoffee Break
10:30 am - 11:30 amAlexey Zaitsev (SUNY Syracuse)
Many Faces of Ventricular Fibrillation in an Ischemic Heart
11:30 am - 12:30 pmAlain Karma (Northeastern University)
Nonlinear dynamics of fibrillation
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Atrial Fibrillation from Bench to Bedside
Discussion Leader: David Van Wagoner (Cleveland Clinic)
7:30 pm - 8:10 pmUrsula Ravens (Technical University Dresden, Germany)
Ion channel remodeling and atrial fibrillation
8:10 pm - 8:50 pmStanley Nattel (Montreal Heart Institute)
Mechanisms of atrial fibrillation in animal models
8:50 pm - 9:30 pmAndrea Natale (Cleveland Clinic)
Mechanisms of atrial fibrillation in man
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetics and Arrhythmogenesis
Discussion Leader: Michael Sanguinetti (University of Utah)
9:00 am - 10:00 amIra Cohen (SUNY at StonyBrook)
Genes, Stem Cells, Funny Currents and Biological Pacemakers
10:00 amCoffee Break
10:30 am - 11:30 amBarry London (University of Pittsburgh)
Molecular genetics of Channelopathies
11:30 am - 12:30 pmWojciech Zareba (University of Rochester)
Risk stratification of channelopathies
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cells and the future of Cardiac Arrhythmias
Discussion Leader: André Kléber (University of Berne)
7:30 pm - 8:10 pmLeo Gepstein (Technion, Haifa Israel)
Somatic gene and cell therapy strategies for the treatment of cardiac arrhythmias
8:10 pm - 8:50 pmRonald Li (Johns Hopkins)
Electrophysiological properties of pluripotent human and mouse embryonic stem cells
8:50 pm - 9:30 pmTimothy Kamp (University of Wisconsin - Madison)
Diversity of cardiomyocytes derived from human embryonic stem cells
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Acknowledgments

Sponsors:
GORDON RESEARCH CONFERENCES
CV THERAPEUTICS
NATIONAL INSTITUTES OF HEALTH
THE WHITAKER FOUNDATION
ASTRAZENECA
MEDTRONIC, INC
PFIZER, INC.
CARL STORM UNDERRPRESENTED MINORITY FELLOWSHIPS

Logo Designer:
Florence Rothenberg


Last Updated: August 14, 2006