Conference Program
 
GRADIENT SENSING & DIRECTED CELL MIGRATION

February 20-25, 2005
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Chair:
Peter N. Devreotes

Vice Chair:
Jeffrey Segall

This meeting will focus directly on mechanisms of eukaryotic chemotaxis. Because chemotaxis is critical for development (especially in neurobiology), immunology, wound healing, and tumor cell metastasis, the meeting is designed to bring together the leading chemotaxis researchers in these fields for cross-fertilization of concepts and approaches. This strategy is manifested by organizing each topic according to stage in the signal processing pathway; for example, researchers in different fields who are focused chemotaxis receptors are grouped together in a single session. The session topics are chosen to focus attention on the critical steps in chemotactic signaling, providing attendees with an integrated overview of the entire chemotaxis process over the course of the entire meeting.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:00 pmSignaling Strategies in Bacterial and Eucaryotic Chemotaxis
Keynote Speaker: Sandy Parkinson, University of Utah
"Bacterial Chemotaxis: Signal Gain Through Receptor Teamwork"
Keynote Speaker: Mel Simon, California Institute of Technology
"Signal Transducing Networks in Macrophage: A report from your AFCS"
9:00Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 am Photo
9:00 am - 12:30 pmDirected Cell Migration in Development I
Discussion Leader: Ruth Lehmann, NYU Medical Center
"Multiple Signals Guide Drosophila Germ Cells"
Erez Raz, Max Planck Institute for Biophysical Chemistry
"Directed Migration of Primordial Germ Cells in Zebrafish"
Alex Kolodkin, Johns Hopkins University School of Medicine
"Semaphorin-mediated neuronal and non-neuronal guidance"
Mu-Ming Poo, University of California at Berkeley
"Calcium Signaling in Axon Guidance and Neuronal Migration"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Workshops (Optional/Informal)
4:00 pm - 6:00 pmPoster Session A [ pdf file ]
6:00 pmDinner
7:30 pm - 9:30 pmDirected Cell Migration in Development II
Discussion Leader: Denise Montell, Johns Hopkins University
"Developmental Regulation of Border Cell Migration"
Pernille Rorth, European Molecular Biology Laboratory
"Gradient sensing and tension sensing in invasive border cell migration"
Kees Weijer, University of Dundee
"Chemotaxis and its role in tissue morphogenesis"
David Soll, University of Iowa
"Spatial and Temporal Information, Lateral Pseudopod Formation, and Parallel Signal Transduction Pathways in Dictyostelium Chemotaxis"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Networks in Chemotaxing Cells I
Discussion Leader: Henry Bourne, University of California at San Francisco
"Signaling via cytoskeletons"
Verena Niggli, University of Bern
"Cytoskeletal reorganization, polarization and migration of neutrophils: roles of Rho/Rho-kinase, PI 3-kinase and lipid microdomains"
Richard Firtel, University of California - San Diego
"Signaling pathways controlling leading edge formation"
Peter J. van Haastert, University of Groningen
"Contributions of PI(3,4,5)P3 and cGMP to chemotaxis at the front and back of Dictyostelium cells"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Workshops (Optional/Informal)
4:00 pm - 6:00 pmPoster Session A [ pdf file ]
6:00 pmDinner
7:30 pm - 9:30 pmSignaling Networks in Chemotaxing Cells II
Discussion Leader: Lew Cantley, Harvard Medical School
"Role of PI 3-Kinase in Actin Rearrangement"
Tobias Meyer, Stanford University
"Probing mammalian cell signaling networks using RNAi perturbations"
Stephen Ward, Bath University
"PI3K and T Lymphocytes: does it have a role in chemotaxis?"
Carole Parent, National Cancer Institute, Bethesda
"Signal relay during chemotaxis"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Networks in Migrating Cells III
Discussion Leader: Rick Horwitz, University of Virginia
"Adhesive and protrusive dynamics in migrating cells"
Anna Huttenlocher, University of Wisconsin-Madison
"Regulated Proteolysis by Calpain During Neutrophil Chemotaxis"
Alan Wells, University of Pittsburgh
"Front-Back Asymmetry During EGF-induced Cell Motility"
Gareth Jones, King's College London
"WASP-mediated regulation of podosomes in migrating myeloid cells"
Diane Barber, University of California - San Francisco
"H+ efflux at the leading edge: a key determinant in polarity and localized actin polymerization"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Workshops (Optional/Informal)
4:00 pm - 6:00 pmPoster Session B [ pdf file ]
6:00 pmDinner
7:30 pm - 9:30 pmModeling of Chemotactic Signaling Networks
Discussion Leader: Hans Meinhardt, Max Planck Institute for Developmental Biology
"Models for the Orientation of Cell Polarity by Weak Chemotactic Gradients"
Pablo Iglesias, Johns Hopkins University
"Modeling gradient sensing in Dictyostelium"
Yu-Li Wang, University of Massachusetts Medical School
"Top-Down Stohastic Modeling of Cell Migration and Gradient Guidance"
Jason Haugh, North Carolina State University
"PDGF gradient sensing in fibroblasts: the 'absolute' truth"
Herbert Levine, University of California, San Diego
"A critical evaluation of gradient-sensing models"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSmall GTPases and Directional Responses
Discussion Leader: Alan Hall, University College London
"Coordinated polarization of actin and microtubules during directed cell migration"
Matthias Peter, Swiss Federal Institute of Technology
"Regulated interactions of the yeast cytoskeleton with the bud cortex"
Erfei Bi, University of Pennsylvania School of Medicine
"Coordinated Regulation of Polarized Growth by a Protein Complex Containing Rab GAPs, a Formin, and a Scaffold Protein"
Dianqing Wu, University of Connecticut
"Regulation of Directionality by Chemoattractant Signaling Pathways"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Workshops (Optional/Informal)
4:00 pm - 6:00 pmPoster Session B [ pdf file ]
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of the Cytoskeleton
Discussion Leader: Anne Ridley, Ludwig Institute for Cancer Research
"Directed migration of leukocytes across endothelial cells"
John Condeelis, Albert Einstein College of Medicine
"Sensing, protrusion and polarity during chemotaxis of tumor cells"
Guenther Gerisch, Max Plauch Institute, Martinstried
"Dynamics of the actin system in chemotaxis"
Richard Klemke, Scripps Research Institute
"Proteomic Analysis of Phosphoprotein Signaling Networks in Cell Chemotaxis"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Last Updated: August 14, 2006