Conference Program
 
ORGANIC REACTIONS & PROCESSES

July 31 - August 5, 2005
Bryant University
Smithfield, RI

Chair:
Steven A. King

Vice Chair:
Matt C. McIntosh

The 2005 Gordon Research Conference on Organic Reactions and Processes will present the best of academic and industrial chemistry with a focus on novel reactions, reaction mechanisms and organometallic chemistry. An excellent list of speakers has been assembled.

A key part of every Gordon Conference is the poster sessions. The poster sessions will be organized by this year's co-chair and all conferees are encouraged to participate.

This year's site, Bryant University, is a very modern campus. The conference hall, extra curricular facilities, and dormitories are first rate.

Steve King, Chair
Matt McIntosh, Vice-Chair

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
Welcome Reception
6:00 pmDinner
7:20 pmWelcome and Introductory Remarks
7:30 pm - 9:30 pmNew Reactions in Organic Synthesis 1
Discussion Leader: Steve Wittenberger (Abbott Laboratories)
7:30 pm - 8:20 pmEd Vedejs (University of Michigan)
"Heteroatom-Directed Hydroboration"
8:20 pm - 8:55 pm David Barnes (Abbott Laboratories)
"Process Development of Quinolone Antibiotic ABT-492"
8:55 pm - 9:30 pm Sergey Kozmin (University of Chicago)
"From New Catalytic Reactions to Complex and Diverse Molecular Architecture"
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amPhoto
9:00 am - 12:30 pmOrgano Metallic Chemistry in Organic Synthesis
Discussion Leader: Elaine Lee (MIT)
9:00 am - 9:45 amDavid Collum (Cornell University)
"Organolithium Structure-Reactivity Relationships: Challenging Problems from Pharmaceutical Process Research"
9:45 am - 10:30 amViresh Rawal (University of Chicago)
"Enantioselective Catalysis of Cycloaddition Reactions"
10:30 am - 10:45 am Coffee Break
10:45 am - 11:20 amJerry Murry (Merck)
"Synthesis and Development of a Moderately Complex Clinical Candidate"
11:20 am - 11:55 amDali Sames (Columbia University)
"Complex Organic Synthesis via C-H Bond Functionalization: New Reactions"
11:55 am - 12:30 pm Shannon Stahl (University of Wisconsin, Madison)
"Palladium-Catalyzed Aerobic Oxidation Reactions"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #1
6:00 pmDinner
7:30 pm - 9:30 pmRecent Developments in Catalysis
Discussion Leader: Margaret Hsu (Abbott Laboratories)
7:30 pm - 8:20 pm David MacMillan (California Institute of Technology)
"Enamine catalysis, teaching an old dog some new tricks"
8:20 pm - 8:55 pm Sally Gut (Pfizer)
"Development and Optimization of a Process for a Pyrrolopyrimidine Compound"
8:55 pm - 9:30 pm Brian Stoltz (California Institute of Technology)
"Recent Developments in Asymmetric Palladium Catalyzed Oxidation and Bond Forming Reactions Inspired by Natural Product Total Synthesis"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Reactions in Organic Synthesis 2
Discussion Leader: Karl Scheidt (Northwestern University)
9:00 am - 9:45 am Shu Kobayashi (The University of Tokyo)
"Towards Truly Efficient and Powerful Organic Synthesis"
9:45 am - 10:30 am Jonathan Ellman (University of California, Berkeley)
"Efficient New Methods for Carbon-Carbon Bond Formation"
10:30 am - 10:45 amCoffee Break
10:45 am - 11:20 amKai Rossen (DeGussa)
"New Developments from the Laboratories of a Fine Chemicals Manufacturer"
11:20 am - 11:55 amTom Rovis (Colorado State University)
"Stereoselective Methods for the Synthesis of Contiguous Stereocenters"
11:55 am - 12:30 pmGreg Dake (University of British Columbia)
"Methods Forming Complex Azacyclic Arrays"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / ORP Golf Classic
6:00 pmDinner
7:30 pm - 9:30 pmMechanistic Chemistry 1
Discussion Leader: Rodney Parsons (BMS)
7:30 pm - 8:20 pmDonna Blackmond (Imperial College)
"Mechanistic Studies of Proline-Mediated Reactions"
8:20 pm - 8:55 pmEd Delany (BMS)
"Chemistry and Control of N-nitrosamine Impurities in Drug Candidates Possessing Secondary Amines"
8:55 pm - 9:30 pm Peter Harrington (Roche)
"Synthetic Strategies to Roche NK-1 Receptor Antagonists"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSelectivity and Target Oriented Syntheis
Discussion Leader: Lisa Reeder (Pfizer)
9:00 am - 9:45 am Steven Burke (University of Wisconsin, Madison)
"Exploitation of Local-, Hidden-, and Imposed Symmetry in Target-Oriented Synthesis"
9:45 am - 10:30 am Scott Rychnovsky (University of California, Irvine)
"New Methods for Natural Product Synthesis"
10:30 am - 10:45 amCoffee Break
10:45 am - 11:20 amBernhard Breit (Freiburg)
"Controlling Selectivity in Metal-Catalyzed and Metal-Mediated Carbon-Carbon Bond Formation"
11:20 am - 11:55 amMelanie Sanford (University of Michigan)
"Synthetic Applications and Mechanistic Investigations of Directed C-H Bond Oxidation"
11:55 am - 12:30 pmBruce Lu (Boehringer Ingelheim Pharmaceuticals)
"Practical Process for Synthesis of 2,3-Disubstituted Indoles and Polycyclic Indole Alkaloids: Novel Palladium-Catalyzed Inter- and Intramolecular Indolization of 2-Chloroanilines with Internal Alkynes"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #2
6:00 pmDinner
7:30 pm - 9:30 pmOrgano Metallic Chemistry in Organic Synthesis 2
Discussion Leader: Margaret Faul (Amgen)
7:30 pm - 8:20 pm Dick Schrock (Massachusetts Institute of Technology)
"Recent Studies Concerning High Oxidation State Alkylidene and Alkylidyne Complexes"
8:20 pm - 8:55 pmWayne Luke (Eli Lilly)
"Development of an Efficient Commercial Synthesis for the Selective Estrogen Receptor Modulator Arzoxifene"
8:55 pm - 9:30 pmBill Thurmes (Displaytech)
"Liquid Crystals: A Ubiquitous Oxymoron"
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanistic Chemistry 2
Discussion Leader: Matt McIntosh
9:00 am - 9:45 amDaniel Singleton (Texas A&M University)
"Dynamic Effects in Ordinary Organic Reactions in Solution"
9:45 am - 10:30 amGuy Lloyd-Jones (University of Bristol)
"Stereochemical Aspects of Some Organometallic Processes"
10:30 am - 10:45 amCoffee Break
10:45 am - 11:20 am Michel Journet (Merck)
"Long Term Factory Process for the Production of a Prostaglandin D2 Receptor Antagonist - Unprecedented Asymmetric Hydrogenation of an Indole Exo-Cyclic Trisubstituted a,b-Unsaturated Acid"
11:20 am - 11:55 amPoster Competition: TBA
11:55 am - 12:30 pmPoster Competition: TBA
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / Academic versus Industrial Softball Game; Chairs Reception
6:00 pmDinner
7:30 pm - 9:30 pmSpecial Lecture
Discussion Leader: Bill Bailey (University of Connecticut)
7:30 pm - 8:05 pmPoster Competition: TBA
8:05 pm - 8:40 pmPoster Competition: TBA
8:40 pm - 9:30 pmReinhard Hoffmann (Philipps-University Marburg)
"Where are we on our way towards the ideal synthesis?"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: August 14, 2006