| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE ADDRESS |
| Discussion Leader: Franz Schmid (Universität Bayreuth) |
| 7:30 pm - 8:30 pm | Susan Lindquist (Massachusetts Institute of Technology)
The surprising biology and biochemistry of prion proteins |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | PROTEIN FOLDING AND DYNAMICS |
| 9:00 am - 9:05 am | Discussion Leader: Terry Oas (Duke University) |
| 9:05 am - 9:30 am | George Rose (Johns Hopkins University)
Some thoughts about the unfolded ensemble |
| 9:40 am - 10:05 am | Art Palmer (Columbia University)
Protein motions in folding, binding, and catalysis |
| 10:15 am - 10:40 am | Sheena Radford (University of Leeds)
Exploring the energy landscape of helical protein folding: from ensemble methods to single molecules |
| 10:50 am - 11:20 am | Coffee Break |
| 11:20 am - 11:45 am | Andy Robertson (University of Iowa)
Mechanisms of conformational divergence among structurally homologous proteins: adaptation of Ubiquitin to insertions from Ubiquitin-like proteins |
| 11:55 am - 12:20 pm | Vijay Pande (Stanford University)
Folding@Home: simulating protein folding, misfolding, and aggregation on the millisecond timescale in atomistic detail |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEIN FOLDING AND DYNAMICS |
| 7:30 pm - 7:35 pm | Discussion Leader: Sheena Radford (University of Leeds) |
| 7:35 pm - 8:00 pm | Dan Raleigh (State University of New York, Stony Brook)
High resolution studies of protein folding |
| 8:10 pm - 8:35 pm | Rudi Glockshuber (Swiss Federal Institute of Technology (ETH))
Assembly of type 1 pili in Escherichia coli |
| 8:45 pm - 8:55 pm | Poster Talk: Patricia Clark (University of Notre Dame)
Influence of Translation on Protein Folding |
| 9:00 pm - 9:10 pm | Poster Talk: Matthew Neiditch (Princeton University)
Regulation of LuxPQ receptor activity by the quorum sensing signal autoinducer-2 |
| 9:15 pm - 9:25 pm | Poster Talk: Euiyoung Bae (University of Wisconsin-Madison)
Structural dissection of stability and activity in adenylate kinase: Connections between structure, function and dynamics |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN DESIGN |
| 9:00 am - 9:05 am | Discussion Leader: Donald Doyle (Georgia Institute of Technology) |
| 9:05 am - 9:30 am | Homme Hellinga (Duke University)
Computational design of biologically active receptors and enzymes |
| 9:40 am - 10:05 am | Brian Kuhlman (University of North Carolina, Chapel Hill)
Computer-based design of protein interfaces and switches |
| 10:15 am - 10:40 am | Lynne Regan (Yale University)
Folding and design of helical repeat proteins |
| 10:50 am - 11:20 am | Coffee Break |
| 11:20 am - 11:45 am | Steve Mayo (California Institute of Technology)
Towards the de novo design of protein-protein interactions |
| 11:55 am - 12:20 pm | Andreas Plueckthun (Universität Zürich)
Synthetic repeat proteins: biophysical analysis and combinatorial engineering |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NATIVELY DISORDERED PROTEINS |
| 7:30 pm - 7:35 pm | Discussion Leader: Trevor Creamer (University of Kentucky) |
| 7:35 pm - 8:00 pm | Peter Wright (Scripps Research Institute)
Role of induced protein folding in the regulation of transcription |
| 8:10 pm - 8:35 pm | Keith Dunker (Indiana University School of Medicine)
Intrinsic disorder and protein function |
| 8:45 pm - 8:55 pm | Poster Talk: Lauren Schwimmer (Georgia Institute of Technology)
Engineering ligand-receptor pairs for small molecule control of transcription |
| 9:00 pm - 9:10 pm | Poster Talk: Anita Lewit-Bentley (CNRS, Cachan)
A new weapon in a microbial pathogen's arsenal: the crystal structure of Bacillus anthracis spore surface protein reveals unexpected mimicry of the mammalian innate immune system |
| 9:15 pm - 9:25 pm | Poster Talk: Mark DePristo (Harvard University)
Missense meandering through sequence space |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MEMBRANE PROTEINS |
| 9:00 am - 9:05 am | Discussion Leader: Chris Hill (University of Utah) |
| 9:05 am - 9:30 am | Robert Stroud (University of California, San Francisco)
The dialectics of transfer across membranes |
| 9:40 am - 10:05 am | Harvey McMahon (MRC Laboratory of Molecular Biology)
Endocytosis goes supersonic |
| 10:15 am - 10:40 am | Lukas Tamm (University of Virginia)
Novel NMR and thermodynamic stability measurements to elucidate the gating mechanism of the OmpA ion channel in membranes |
| 10:50 am - 11:20 am | Coffee Break |
| 11:20 am - 11:45 am | Dinesh Yernool (Columbia University)
Structure of a glutamate transporter homolog from Pyrococcus horikoshii |
| 11:55 am - 12:20 pm | Jim Bowie (University of California, Los Angeles)
Membrane protein folding and applications |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEINS IN DISEASE |
| 7:30 pm - 7:35 pm | Discussion Leader: Gary Pielak (University of North Carolina, Chapel Hill) |
| 7:35 pm - 8:00 pm | Ron Wetzel (University of Tennessee)
Kinetics and thermodynamics of amyloid fibril formation |
| 8:10 pm - 8:35 pm | Jonathan Weissman (University of California, San Francisco)
Mechanism of amyloid formation and propagation: lessons from a yeast prion |
| 8:45 pm - 8:55 pm | Luke Rice (University of California, San Francisco)
Insights into microtubule assembly from the crystal structure of human gamma-tubulin |
| 9:05 pm - 9:15 pm | Matt Simon (University of California, San Francisco)
Re-engineering a protein-DNA interface using unnatural nucleotides |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN COMPLEXES AND NETWORKS |
| 9:00 am - 9:05 am | Discussion Leader: Volker Doetsch (Johann Wolfgang Goethe University) |
| 9:05 am - 9:30 am | John Kuryian (University of California, Berkeley)
Auto-regulation mechanisms in kinases and related signaling proteins |
| 9:40 am - 10:05 am | Lila Gierasch (University of Massachusetts, Amherst)
Interdomain allosteric coupling networks in Hsp70 molecular chaperones |
| 10:15 am - 10:40 am | Art Johnson (Texas A&M University)
Mechanism of BiP-mediated gating of the aqueous ER translocon pore |
| 10:50 am - 11:20 am | Coffee Break |
| 11:20 am - 11:45 am | Janet Thornton (European Bioinformatics Institute)
Protein-ligand interactions - exploring conformational diversity and ligand recognition |
| 11:55 am - 12:20 pm | Tania Baker (Massachusetts Institute of Technology)
Re-sculpting proteins and the proteome by the ClpX AAA+ ATPase |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CLOSING KEYNOTE ADDRESS |
| Discussion Leader: Virginia Rath |
| 7:30 pm - 8:30 pm | Wendell Lim (University of California, San Francisco)
The logic and design of modular cell signaling systems |
| 8:30 pm - 9:30 pm | Business Meeting |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |