Conference Program
 
BIOLOGY OF 14-3-3 PROTEINS

August 27 - September 1, 2006
The Queen's College
Oxford, United Kingdom

Chair:
Alastair Aitken

Vice Chair:
Tohru Ichimura

The "Biology of 14-3-3 Proteins" meeting focuses on a family of highly conserved molecules - found in all eukaryotic cells. The common theme describing 14-3-3 protein function is that they act by binding specific target proteins. Interaction in most cases is regulated by phosphorylation of these targets.

14-3-3 proteins are involved in an impressively diverse range of functions, including cell division, apoptosis, signal transduction, transmitter release, receptor function, ion channel physiology, gene expression, transmitter synthesis, neurodegenerative diseases and enzyme activation/protection. 14-3-3 proteins are being studied on a broad front, involving plants, yeast and vertebrates and a similarly broad range of systems and functions. The broad nature of 14-3-3 research means that investigators working on 14-3-3 proteins in the vertebrate nervous system do not typically meet with those working on in plants, thereby missing the opportunity to be stimulated by new approaches, experiences and findings from a distantly related program. This cross-fertilization will enrich research in this area by promoting discussion and enhancing the exchange of ideas and new discoveries between these scientists in the stimulating setting of a Gordon Research Conference.

In addition to the speakers listed below, some short talks will be selected from submitted abstracts.

Travel awards for selected postdoctoral fellows, students, and minority participants.

CONTRIBUTORS

BIOMOL International
Cambridge Research Biochemicals
Darwin Trust of Edinburgh

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments
7:40 pm - 9:30 pmOPENING SESSION
Discussion Leader: Haian Fu (Emory University, USA)
7:40 pm - 8:25 pmKeynote Address: John Scott (Vollum Institute, USA)
"The Molecular Architecture of Signaling Complexes"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmKeynote Address: Tony Pawson (Samuel Lunenfeld Research Institute, Canada)
"TBA"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTRUCTURE AND LIGAND RECOGNITION
Discussion Leader: David C. Klein (National Institutes for Health, USA)
9:00 am - 9:25 am Michael Yaffe (Center for Cancer Research, MIT, USA)
"A Novel Role for 14-3-3 Sigma in Mitosis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am Louis Mahadevan (University of Oxford, UK)
"Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3"
10:00 am - 10:10 amDiscussion
10:10 am - 10:45 amCoffee Break
10:45 am - 11:10 am Tomas Obsil (Charles University, Prague, Czech Republic)
"14-3-3 protein C-terminal stretch: the role of its conformation in the regulation of ligand binding"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 am Declan Doyle (Oxford University, UK)
"Structures of 14-3-3 isoforms"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pm Walter Kolch (Beatson Cancer Research, Glasgow, UK)
"14-3-3 and Raf regulation, Raf heterodimerisation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMITOGENIC AND ONCOGENIC SIGNAL TRANSDUCTION
Discussion Leader: Guri Tzivion (Karmanos Cancer Institute, Wayne State University, USA)
7:30 pm - 7:55 pm Heiko Hermeking (Max-Planck-Institute of Biochemistry, Germany)
"Analysis of 14-3-3sigma, a p53-regulated isoform silenced in cancer"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pm Satoshi Inoue (University of Tokyo, Japan)
"Post-translational modification of 14-3-3sigma by E3 ligase Efp"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pm Guri Tzivion (Karmanos Cancer Institute, Wayne State University, USA)
"14-3-3 proteins as potential oncogenes"
9:05 pm - 9:15 pmDiscussion
TUESDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pm GENETICS AND DEVELOPMENT
Discussion Leader: Tony Muslin (Washington University School of Medicine, USA)
9:00 am - 9:25 am Paul van Heusden (Leiden University, the Netherlands)
"The yeast Saccharomyces cerevisiae as model organism to study 14-3-3 protein function"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am Anthony Wynshaw-Boris (University of California, San Diego, USA)
"The role of 14-3-3 proteins during brain development"
10:00 am - 10:10 amDiscussion
10:10 am - 10:50 amCoffee Break
10:50 am - 11:15 am Maria Zannis-Hadjopoulos (McGill Cancer Centre, Montreal, Canada)
"The cruciform binding activity of 14-3-3 as a regulator of DNA replication"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amJan Szopa (University of Wroclaw, Poland)
"Study of 14-3-3 Gene Promoters"
11:50 am - 12:00 pmDiscussion
12:45 pmGroup Photo Followed by Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 12:30 pmCELL CYCLE CONTROL AND APOPTOSIS
Discussion Leader: Heiko Hermeking (Max-Planck-Institute of Biochemistry, Germany)
7:30 pm - 7:55 pm Haian Fu (Emory University, USA)
"Development of 14-3-3 modulators"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAngel F. Lopez (IMVS, Hanson Centre, Adelaide, Australia)
"Regulation of cytokine receptor signalling by 14-3-3 proteins"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmJo Woodcock (IMVS, Adelaide, Australia)
"14-3-3 is a sphingolipid-binding protein"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmUlf Rapp (Institut fuer Medizinische Strahlenkunde und Zellforschung, Wuerzburg, Germany:)
"14-3-3 and regulation of membrane interaction of BAD"
9:15 pm - 9:25 pmDiscussion
WEDNESDAY
7:45 am - 8:30 amBreakfast
9:00 am - 12:30 pmMETABOLIC REGULATION
Discussion Leader: Carol MacKintosh (University of Dundee, Scotland, UK)
9:00 am - 9:25 am David C. Klein ( National Institutes for Health, USA)
"The Biology of the 14-3-3/AANAT Complex"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am Carol MacKintosh (University of Dundee, Scotland, UK)
"14-3-3s regulate nutrient assimilation in plant and human cells in response to growth factors and energy stress"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 am Aziz Ghahary (University of British Columbia, Canada)
"Biological Role of Extracellular 14-3-3 Proteins in Normal and Pathological Conditions"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 am Patrizia Aducci (University of Rome-Tor Vergata, Italy)
"Regulation of the Potassium Channel Kat1 by 14-3-3 Proteins"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pm Claudia Oecking (University of Tuebingen, Germany)
"Co- structure of 14-3-3 in complex with a domain of the H+-ATPase"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmHOT TOPICS: NOVEL FUNCTIONS AND REGULATION
Discussion Leader: Michael Yaffe (Center for Cancer Research, MIT, USA)
7:30 pm - 7:55 pmTony Muslin (Washington University School of Medicine, USA)
"Differential role of 14-3-3 family members in Xenopus development"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRobert Rottapel (Ontario Cancer Institute, Canada)
"14-3-3 regulates the mitotic spindle RhoGEF LFC"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmNick La Thangue (Oxford, UK)
"14-3-3 proteins integrate E2F activity with the DNA damage response"
9:05 pm - 9:15 pmDiscussion
THURSDAY
7:45 am - 8:30 amBreakfast
9:00 am - 9:30 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:30 am - 12:30 pm14-3-3 AND BRAIN DISEASES
Discussion Leader: Markus Otto (University of Ulm, Germany)
9:30 am - 9:55 amMarkus Otto (University of Ulm, Germany)
"14-3-3 proteins in the diagnosis of neurodegenerative disease"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amAzad Bonni (Harvard Medical School, USA)
(Dorothy Dillon Eweson Lecturer on the Advances in Aging Research)
"MST Regulation of Oxidative Stress Responses and Longevity"
10:30 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:25 am Efthimios Skoulakis (Institute of Molecular Biology and Genetics, Vari, Greece)
"14-3-3s enhance tauopathies in Drosophila"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 am Michael C Berndt (Immunology, AMREP, Melbourne, Australia)
"14-3-3 zeta binding to platelet GPIb-IX-V adhesion receptor, role in heart disease and stroke"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMary Waye (The Chinese University of Hong Kong)
"Genetic susceptibility of Suicide: 14-3-3 epsilon or SSAT?"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pm14-3-3 IN RECEPTOR SIGNALING
Discussion Leader: Claudia Oecking (University of Tuebingen, Germany)
7:30 pm - 7:55 pmBengt Hallberg (Umea University, Sweden)
"Exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmMin Li (Johns Hopkins University, USA)
"Inducible membrane trafficking by mode III 14-3-3 binding"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmBert de Boer (Vrije Universiteit, Amsterdam, the Netherlands)
"Isoform specific functions of 14-3-3 proteins in enzyme regulation and hormonal signaling"
9:05 pm - 9:15 pmDiscussion
FRIDAY
7:45 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: October 11, 2006