| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Aging Biology in Perspective |
| Discussion Leader: Tom Johnson (University of Colorado, Boulder) |
| 7:30 pm - 8:30 pm | Dr. Thomas Kirkwood (University of Newcastle)
"The big WHY? Paradigms and problems in evolution of aging" |
| 8:30 pm - 9:00 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Impact of Insulin/IGF Signaling on Healthspan |
| 9:00 am - 9:05 am | Discussion Leader: TBA |
| 9:05 am - 9:30 am | Gary Ruvkun (Harvard Medical School MGH)
"RNAi screens for C. elegans longevity genes" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Lenny Guarente (MIT)
"SIR2, insulin/IGF1 and aging" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:35 am | Coffee Break |
| 10:35 am - 11:00 am | Julie Pinkston (UCSF)
"Genes affecting aging and age-related disease in C. elegans" |
| 11:00 am - 11:15 am | Discussion |
| 11:15 am | Group Photo |
| 11:40 am - 12:05 pm | Brian Kennedy
"Calorie restriction in yeast and worms: Public or private mechanisms?" |
| 12:05 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (Author last name A-L) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Extracellular Matrix in Aging |
| Discussion Leader: Pidder Jansen-Durr (Austrian Academy of Sciences Research, Innsbruk) |
| 7:30 pm - 7:50 pm | Robert C. Baxter (Kolling Institute)
"Interactions of IGFBPs with extracellularly-regulated signaling pathways" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Hassy Cohen (UCLA)
"Role of the IGF/IGFBP axis in aging and cancer" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Olivier Toussaint (Namur University, Belgium)
"TGF-beta signalling in cellular senescence" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | William C. Hornebeck (Centre National de la Recherche Scientifique, Brussels)
"The elastin connection and aging" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mitochondria and Oxidative Stress |
| 9:00 am - 9:10 am | Discussion Leader: David Nicholls (Buck Institute, Novato, CA) |
| 9:10 am - 9:40 am | Siegfried Hekimi (McGill University, Montreal)
"clk-1: from worms to mice and from aging to age-dependent diseases" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Chuck Hoppel (Case Western Reserve University)
"Mitochondrial dysfunction and cardiolipin oxidation in the elderly heart during ischemia/reperfusion" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee break |
| 11:00 am - 11:30 am | Holly Van Remman (Audie Murphy VA Hospital / U. Texas Health Science Center)
"Mitochondrial function and loss of muscle mass in mice lacking CuZn superoxide dismutase" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Thomas Von Zglinicki (University of Newcastle)
"Mitochondrial dysfunction in replicative senescence" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (Authors M - Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Fat and Dietary Restriction |
| Discussion Leader: Steve Helfand (Brown University) |
| 7:30 pm - 7:50 pm | Kaveh Ashrafi (UCSF)
"C. elegans fat regulatory pathways" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Su-Ju Lin (UC Davis)
"Nutrient sensing pathways and calorie restriction" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Pere Puigserver (Johns Hopkins)
"Nutrient control of glucose homeostasis through the PGC-1 pathway" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | David Sinclair (Harvard Medical School)
"Chromatin shuffling as a cause of mammalian aging" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Systems Networks in Aging |
| 9:00 am - 9:10 am | Discussion Leader: Daniel Promislow (University of Georgia) |
| 9:10 am - 9:40 am | Greg Gibson (North Carolina State University)
"Quantitative approaches to associating genetic networks with disease in Drosophila" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Andreas Wagner (University of New Mexico)
"Natural selection and genetic networks" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee break |
| 11:00 am - 11:30 am | Marie-Anne Felix (Institut Jacques Monod)
"Errors and evolution in the C. elegans vulva development network" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Simon Melov (Buck Institute)
"Heterogeneity in aging - is regulation an appropriate term?" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Vascular Function in Aging |
| Discussion Leader: William Sonntag (Wake Forest University Medical Center) |
| 7:30 pm - 7:50 pm | May Reed (University of Washington School of Medicine, Seattle)
"Impaired angiogenesis in aging: implications for wound repair, vascular disease, and cancer" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Larry Kenny (Penn State University)
"Aging and Thermoregulatory Cutaneous Vascular Function" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Gabor Kaley (NY Medical College)
"Oxidative stress and microvascular function in aging" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Mark Nelson (University of Vermont)
"Neurovascular coupling in aging" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Impact of Immunity and Sensation on the Ability to Live Long and Healthy |
| 9:00 am - 9:10 am | Discussion Leader: Marc Tatar (Brown University) |
| 9:10 am - 9:40 am | Danielle Garsin (U. Texas Health Science Center, Houston Medical School)
"Mechanisms of bacterial infection and host defense in C. elegans" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Janet Lord (University of Birmingham)
"Stress responses, neutrophil function and aging" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee break |
| 11:00 am - 11:30 am | Rita Effros (UCLA)
"T cells, telomeres and telomerase: aging and immune exhaustion" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Scott Pletcher (Baylor College of Medicine)
"Hijacking the senses: Regulating Drosophila longevity through olfaction" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Maintenance of Macromolecular Integrity |
| Discussion Leaders: Holly Brown-Borg (University of North Dakota), Alexander Bürkle (University of Konstanz) & LaDora Thompson (U. of Minnesota) |
| 7:30 pm - 7:50 pm | Jackob Moskovitz (University of Kansas)
"The methionine sulfoxide reductase system and its roles in antioxidant defense and survival" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Alfred Goldberg (Harvard University)
"Role of the proteasome in degradation of misfolded proteins" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Vilhelm Bohr (NIA, Baltimore)
"Role of Werner and other human premature aging proteins in the maintenance of genomic integrity" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Grace Pavlath (Emory University)
"Regulation of myogenic stem cells" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |