| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNTHESIS AND BIOSYNTHESIS OF OLIGOSACCHARIDES: SWEET! |
| Discussion Leader: Lara Mahal (University of Texas at Austin) |
| 7:30 pm - 8:00 pm | Martin Tanner (University of British Columbia)
"Mechanistic Studies on the ADP-Heptose 6-Epimerase of Lipopolysaccharide Biosynthesis" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Rob Field (University of East Anglia)
"Self-Assembly and the Plant Cell Wall" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jim Naismith (University of St Andrews)
"Carbohydrate Synthesis from the Inside to the Outside" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | EVOLUTION AND (INTELLIGENT) DESIGN |
| Discussion Leader: Rebekka Wachter (Arizona State University) |
| 9:00 am - 9:30 am | Hiro Suga (University of Tokyo)
"The mRNA-Directed Synthesis of Nonnatural Polypeptides and Polyester Hybrids via the Genetic Code Reprogramming" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Poster Talk: Jason Chin (MRC Cambridge)
"Synthesizing Cellular Networks from Evolved Ribosome-mRNA Pairs"
|
| 9:55 am - 10:30 am | Group Photo and Coffee Break |
| 10:30 am - 11:00 am | Lutz Jermutus (Cambridge Antibody Technology)
"Directed Protein Evolution for Biopharmaceutical Discovery" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Alanna Schepartz (Yale University)
"Exploring Biology with Molecules Nature Chose not to Synthesize" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 am | Mark Smythe (Protagonist Pty Ltd)
"What is biologically and functionally relevant chemical space and how can we force chemistry to sample this space?" |
| 12:20 am - 12:30 am | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ANTIBIOTICS: BIOSYNTHESIS AND MECHANISMS OF ACTION |
| Discussion Leader: Paul Berti (McMaster University) |
| 7:30 pm - 8:00 pm | Neil Thomas (University of Nottingham)
"Studies on Lysostaphin, an Anti-microbial Protease" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Wilfred van der Donk (University of Illinois)
"Mechanism and Application of Lantibiotic Synthases" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | John Blanchard (Albert Einstein College of Medicine)
"The Multiplicity of Mechanisms of Antibiotic Resistance in Mycobacterium tuberculosis" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | FOLLOWING THE YELLOW BRICK ROAD: PATHWAYS FOR ASSEMBLING MOLECULES IN CELLS |
| Discussion Leader: Michelle Hamm (University of Richmond) |
| 9:00 am - 9:30 am | Michael Burkart (University of California San Diego)
"Coenzyme A and Natural Product Biosynthesis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Tadhg Begley (Cornell University)
"Mechanistic and Structural Studies on Thiamin Biosynthetic Enzymes" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Ben Davis (University of Oxford)
"Sugars & Enzymes" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Suzanne Walker (Harvard Medical School)
"The Moenomycin Biosynthetic Gene Cluster" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk: Alison Hulme (University of Edinburgh)
"Application of the Huisgen 1,3-Dipolar Cycloaddition Reaction to Molecular Probe Design: A Unified Approach to Biotinylation" |
| 12:10 pm - 12:25 pm | Poster Talk: Richard Lee (University of Tennessee)
"Mechanistic Studies of Dihydropteroate Synthase" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | LIGHT AT THE END OF THE PIPELINE? |
| Discussion Leader: Jeffrey Keillor (Université de Montréal) |
| 7:30 pm - 8:00 pm | Girija Krishnamurthy (Wyeth Research)
"HCV polymerase and Akt kinase: Discovery of allosteric inhibitors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | David Rees (Astex Therapeutics Limited)
"From Crystal to Clinic using Fragment Based Drug Discovery" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Paul Richardson (Abbott Laboratories)
"Rapid Determination of the Primary Substrate Specificity of Proteases" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | UNDERSTANDING AND DISSECTING COMPLEX SYSTEMS |
| Discussion Leader: Ryan Mehl (Franklin and Marshall College) |
| 9:00 am - 9:30 am | Shankar Balasubramanian (University of Cambridge)
"Nucleic Acid Quadruplexes in the Genome" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Jürgen Plitzko (Max Planck Institute of Biochemistry, Martinsried)
"Cryo-electron tomography (CET): A tool to study cells in 3 dimensions" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Hagan Bayley (University of Oxford)
"Towards Rapid Screening of Channels and Pores" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Dan Kahne (Harvard University)
"Studies on Organelle Biogenesis" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk: Coran Watanabe (Texas A&M University)
"Azinomycin B: Mode of Action and Biosynthesis" |
| 12:10 pm - 12:25 pm | Poster Talk: Kurt Deshayes (Genentech)
"Selectively Inducing Programmed Cell Death in Cancer Cells: A New Therapeutic Approach." |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | AVOIDING MIXED SIGNALS |
| Discussion Leader: Paramjit Arora (New York University) |
| 7:30 pm - 8:00 pm | Karen Anderson (Yale University)
"Temporal Control of Protein Signaling Events" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Mary Kay Pflum (Wayne State University)
"Histone Deacetylase Proteins: From Post-translational Modification to Small Molecule Inhibition" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Phil Cole (Johns Hopkins University School of Medicine)
"Chemical Approaches to Sorting Out Protein Phosphorylation" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am - 12:30 pm | DIVERSITY: THE SPICE OF LIFE |
| Discussion Leader: Stephen Caddick (University College London) |
| 9:00 am - 9:30 am | Jean-Louis Reymond (University of Bern)
"Peptide Dendrimers as Artificial Enzymes and Glycoproteins" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Derek Tan (Memorial Sloan-Kettering Cancer Center)
"Natural product-based strategies in diversity-oriented synthesis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:35 am - 11:05 am | Peter Seeberger (ETH Zurich)
"Carbohydrate Signaling by Heparin and Glycolipids" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Sharon Cload (Archemix Corporation)
"Recent Developments in Aptamer Therapeutics" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | Poster Talk: Neal Zondlo (University of Delaware)
"Design of Tunable Proteins: Control of Protein Structure by Phosphorylation, by Electronics, and by Stereoelectronics" |
| 12:10 pm - 12:25 pm | Poster Talk: Saulius Klimasauskas (Institute of Biotechnology, Vilnius, Lithuania)
"Synthetic analogs of AdoMet for targeted transalkylation of DNA by methyltransferases" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMICAL BIOLOGY OF DISEASES |
| Discussion Leader: Gautam Sanyal (AstraZeneca R&D Boston) |
| 7:30 pm - 8:00 pm | Andy Crew (OSI Pharmaceuticals, Inc.)
"Thiophene Anthranilamides as Dual Kit/KDR Tyrosine Kinase Inhibitors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Gary Glick (University of Michigan)
"Therapeutic Targeting of Bio-energetic Pathways" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Natural Products Reports Lectureship: Chris Schofield (University of Oxford)
"The Molecular Mechanism of the Hypoxic Response" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 8:00 am - 9:00 am | Breakfast |
| 9:00 am | Departure |