Conference Program
 
PEPTIDES, CHEMISTRY & BIOLOGY OF

February 19-24, 2006
Ventura Beach Marriott
Ventura, CA

Chairs:
Dale F. Mierke & Robert S. Hodges

Vice Chairs:
Carrie Haskell-Luevano & Kit S. Lam

The 2006 Biology & Chemistry of Peptides GRC will present the most recent advances in the field of peptides and peptide-related science. We anticipate an exciting meeting with sessions focused on novel synthetic and spectroscopic methods, peptides in immunology and cancer biology, cell surface receptor interactions, drug delivery, and recent developments in peptidomimetics as well as a wide array of topics to be included in poster and oral presentations selected from submitted abstracts.

We recommend early application to the Peptides GRC as attendance is limited; preference will be given to those who submit a poster abstract to the chairs by November 30, 2005.

We welcome applications from graduate students and young postdoctoral scientists to attend and present their research findings; a number of travel awards will be available judged on submitted poster abstracts.

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:00 pm - 8:00 pmOpening Reception
8:00 pm - 9:30 pmKEYNOTE ADDRESSES
8:00 pm - 8:05 pmR. Hodges and D. Mierke
Introductory Remarks
8:05 pm - 8:45 pmRoger M. Freidinger
"Peptidomimetics and Nonpeptide Ligands for Peptide Receptors: Bradykinin B1 Antagonists"
8:50 pm - 9:30 pmLuis Moroder
"Collagen peptides as synthetic models of the extracellular matrix"
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmG-PROTEIN COUPLED RECEPTORS
Discussion Leader: Dale Mierke (Brown University)
9:00 am - 9:25 am Roland Riek (Salk)
"Structural insights into the peptide ligand-receptor interactions of a GPCR of family B"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Alessandro Bisello (University Pittsburgh)
"Accessory proteins for G protein-coupled receptors"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amSam R.J. Hoare (Neurocrine)
"Mechanisms of ligand binding to Class B G-protein-coupled receptors"
11:05 am - 11:15 amDiscussion
11:15 amGroup Photo
11:35 am - 12:00 pmIndraneel Ghosh (University of Arizona)
"Quantum Dots for targeting GPCRs"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPoster Presentation: William Ja (California Institute of Technology)
"In Vitro Selection of Peptides that Antagonize Methuselah and Extend Drosophila Lifespan"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPEPTIDES IN CANCER BIOLOGY
Discussion Leader: Kit Lam (University California, Davis)
7:30 pm - 7:55 pm Kit Lam (University California, Davis)
"From Combinatorial Chemistry to Cancer Targeting"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pm Terry Moody (National Cancer Institute)
"Bombesin and VIP receptors in lung cancer"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Presentation: Luisa Bracci (University of Siena)
"Branched Neurotensin for Tumor-Selective Targeting"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Ziwei Huang (Burnham Institute)
"Peptides and peptidomimetics targeting apoptotic mechanisms of cancer cells"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDESIGN/SYNTHESIS PEPTIDOMIMETICS
Discussion Leader: Armin Geyer (U. Marburg)
9:00 am - 9:25 am Christian Schafmeister (U. Pittsburgh)
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am William Lubell (U. Montreal)
"New synthetic methodology for making old mimics"
10:00 am - 10:10 am Discussion
10:10 am - 10:20 am Poster Presentation: Michael R. Carrasco (Santa Clara University)
"Synthesis of Neolipopeptides by Chemoselective Alkylation of N-Alkylaminooxy-Containing Peptides"
10:20 am - 10:30 am Discussion
10:30 am - 10:55 amCoffee Break
10:55 am - 11:20 am Mark Spaller (Wayne State University)
"Ligand Design for PDZ Domain Proteins: From Thermodynamic Analysis to Biological Probes"
11:20 am - 11:30 am Discussion
11:30 am - 11:55 am Marcey Waters (U. North Carolina)
"Controlling Biomolecular Recognition with Designed Peptides"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:25 pmDavid Perrin (University of British Columbia)
"Synthetic Approaches to Phakellistatin, Amanitin, and Phalloidin - Expeditious Synthesis of Combinatorial Arrays Thereof"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPEPTIDES: MICROBIOLOGY/IMMUNOLOGY
Discussion Leader: Pravin T.P. Kaumaya (Ohio State University)
7:30 pm - 7:55 pm Pravin T.P. Kaumaya (Ohio State University)
"Combined Peptide Vaccines and Therapeutic Approaches For Optimizing Specific Immune Responses and Clinical Efficacy"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Esteban Celis (LSU Health Sciences)
"Development of Multi-Epitope Peptide-Based Vaccines for Cancer"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Poster Presentation: Brian Tripet (University of Colorado)
"Design and Study of Neutralizing Antibodies Against SARS-CoV Entry"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmClemencia Pinilla (Torry Pines Institute of Molecular Studies)
"Advances in T cell specificity"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDRUG DELIVERY
Discussion Leader: John Mayer (Eli Lily)
9:00 am - 9:25 am Tom Strack (Pfizer)
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am Alessio Fasano (U Maryland)
10:00 am - 10:10 am Discussion
10:10 am - 10:20 am Poster Presentation: Tina Holm (Stockholm University)
"Cell-penetrating peptides derived from the leucine zipper interface of AP-1 for inhibition of proliferation in cancer cells"
10:20 am - 10:30 am Discussion
10:30 amCoffee Break
11:00 am - 11:25 am Eric Dadey (QLT, Inc.)
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Edward Maggio (Aegis Therapeutics, Inc.)
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Poster Presentation: Reto Stöcklin (Atheris Laboratories)
"Pepdidomics-Assisted Drug Discovery in Animal Venoms"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPEPTIDES TO PROTEINS
Discussion Leader: William Lubell (U. Montreal)
7:30 pm - 7:55 pm Armin Geyer (U. Marburg)
"The chemical challenge of synthesizing biological peptides in single conformational states"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Annelise Barron (Northwestern)
"Amphipathic, sequence-specific peptoids as functional mimics of membrane-active peptides"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pm Poster Presentation: Neal J. Zondlo (University of Delaware)
"Design of Tunable Proteins: Control of Protein Structure by Phosphorylation, by Electronics, and by Stereoelectronics"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pm Floyd Romesberg (Scripps)
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPEPTIDES METABOLISM
Discussion Leader: Carrie Haskell-Luevano (U. Florida)
9:00 am - 9:25 am Carrie Haskell-Luevano (U. Florida)
"Structure-Function Studies of the Agouti-Related Protein: Conversion From a Melanocortin Receptor Antagonist to Agonist"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am John Mayer (Eli Lily)
"Melanocortin Agonists for Obesity"
10:00 am - 10:10 am Discussion
10:10 am - 10:20 am Poster Presentation: John M. Stewart (University of Colorado Health Science Center)
"New Bradykinin B-1 Receptor Peptide Antagonists"
10:20 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:25 amDavid Fry (Hoffmann-La Roche)
"Development of Rigid MC-4R Peptide Agonists to Obtain a Refined Pharmacophore Model"
11:25 am - 11:35 amDiscussion
11:35 am - 11:45 am Poster Presentation: Sonia Cantel (Harvard Medical School)
"In Situ eIF4e-Templated Click Reaction - eIF4g-Derived eIF4e Binding Peptides as Anchoring Fragments in Search of Putative Exosites"
11:45 am - 11:55 amDiscussion
11:55 am - 12:30 pm Business Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDU VIGNEAUD AWARDS
Discussion Leader: R. Hodges (U. Colorado)
7:30 pm - 8:20 pm Samuel H. Gellman (University of Wisconsin)
"Structure and Function in Peptidic Foldamers"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pm Barbara Imperiali (Massachusetts Institute of Technology)
"Peptide and Protein Probes for the Study of Complex Biological Systems"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Last Updated: October 11, 2006