Conference Program
 
NITRIC OXIDE

February 4-9, 2007
Crowne Plaza
Ventura, CA

Chair:
William C. Sessa

Vice Chair:
David A. Wink

The Nitric Oxide (NO) GRC is designed to provide chemists, biologists, cell biologists, clinicians and other scientists with state of the art knowledge on the basic structure/function relationships of NO generating systems and the biology of NO as a signaling molecule in physiological and pathophysiological states. The main strength of this meeting is the opportunity for cross disciplinary interactions and exploring new vistas in this important translational field of research.

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and William C. Sessa (Yale University)
7:40 pm - 9:30 pm PLENARY LECTURES
Discussion Leader: Steven S. Gross (Cornell University Medical School)
7:40 pm - 8:25 pm Salvador Moncada (University College London)
"Role of NO in mitochondrial function"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pm Bettie Sue Masters (University of Texas Health Sciences, San Antonio)
"Perspectives in NOS enzymology from insights derived from P450"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NO GENERATING/SENSING PATHWAYS: STRUCTURE AND FUNCTION
Discussion Leader: Brian Crane (Cornell University)
9:00 am - 9:25 am Elizabeth D. Getzoff (The Scripps Research Institute)
"Structural insights into NOS function"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amWilliam R. Montfort (University of Arizona)
"Nitrophorins as NO transport proteins"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break / Group Photo
11:10 am - 11:35 am Dennis Stuehr (Cleveland Clinic Foundation)
"Mechanisms of NOS catalysis"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pm Focco van den Akker (Case Western Reserve University)
"Insights into NO activation of the soluble guanylyl cyclase"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm IN VIVO CHEMISTRY AND ACTIONS OF NO: NO ADDUCTS OR CGMP SIGNALING
Discussion Leader: Charles Lowenstein (The Johns Hopkins Hospital)
7:30 pm - 7:55 pm Mark Gladwin (National Institute of Health)
"Nitrite regulation of regional blood flow control"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm Joan Mannick (University of Massachusetts Medical School)
"S-nitrosylation and ALS"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Doris Koesling (Ruhr-Universitat Bochum)
"Physiological roles of NO-cGMP-PKA pathways in vivo"
9:15 pm - 9:30Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm UNCOUPLED NOS: IS IT REAL IN VIVO? MECHANISMS AND PATHOPHYSIOLOGY
Discussion Leader: Kirk Pritchard (Medical College of Wisconsin)
9:00 am - 9:25 am Antonius Gorren (Karl-Franzen - Universitat Graz)
"Biochemistry of uncoupled NOS: Truth and fiction"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am Jay Zweier (The Ohio State University)
"Detection and generation of superoxide from NOS"
10:05 am - 10:20 amDiscussion
10:20Coffee Break
11:10 am - 11:35 am Ingrid Flemming (Klinikum der J.W. Goethe-Universitat)
"Regulation of eNOS function"
11:35 am - 11:50 amDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm CELLULAR BIOLOGY OF NO AND NOS
Discussion Leader: David Fulton (Medical College of Georgia)
7:30 pm - 7:55 pm Tim Billiar (University of Pittsburgh)
"TBA"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pm N Tony Eissa (Baylor College of Medicine)
"Post-translational control of iNOS"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pm Charles Lowenstein (The Johns Hopkins Hospital)
"NO regulation of secretion"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm TERMINATION OF NO SIGNALING
Discussion Leader: Ferid Murad (University of Texas - Houston Medical School)
9:00 am - 9:25 am Harry Ischiropoulos (University of Pennsylvania)
"Redox regulation of NO bioactivity"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am Limin Liu (University of California, San Francisco)
"Physiological control of SNO activity by SNO reductase"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break
10:40 am - 11:05 am Sharron Francis (Vanderbilt University School of Medicine)
"cGMP phosphodiesterase control of NO signaling"
11:05 am - 11:20 amDiscussion
11:20 am - 12:30 pmHOT TOPICS SESSION (YOUNG INVESTIGATORS AWARDS)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:10 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:10 pm - 9:10 pm Alexander Varshavsky (California Institute of Technology)
"NO and regulated protein degradation"
9:10 pm - 9:25 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ROLES OF NO IN PHYSIOLOGY AND PATHOPHYSIOLOGY
Discussion Leader: Gabor M. Rubanyi (Cardium Therapeutics, Inc.)
9:00 am - 9:25 am Manasi Nandi (University Colllege London)
"Regulation of ADMA in Health and disease"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 am James G. Tidball (University of California, Los Angeles)
"nNOS correction of cardiomyopathy"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break
11:10 am - 11:35 am David Roberts (National Institute of Health)
"Reciprocal control of angiogenesis by NO and thrombospondins"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmKenneth Bloch (Massachusetts General Hospital)
"Role of NO in models of heart disease"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTHERAPEUTIC STRATEGIES AIMED AT REGULATING NO BIOLOGY
Discussion Leader: William C. Sessa (Yale University)
7:30 pm - 7:55 pmVijay Shah (Mayo Clinic)
"Manipulation of NO in liver disease"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmWarren Zapol (Massachusetts General Hospital)
"Inhaled NO as a Therapeutic"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJane R. Connor (Pfizer)
"Role of NO in arthritis"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 HL87437-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: February 1, 2007